scholarly journals Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: Investigating the hypothesis of shared structure–activity relationships

2009 ◽  
Vol 17 (20) ◽  
pp. 7145-7155 ◽  
Author(s):  
Maris A. Cinelli ◽  
Brenda Cordero ◽  
Thomas S. Dexheimer ◽  
Yves Pommier ◽  
Mark Cushman
Keyword(s):  
Topoisomerase I ◽  
Biological Evaluation ◽  
Structure Activity Relationships ◽  
Topoisomerase I Inhibitors ◽  
Structure Activity ◽  
Synthesis And Biological Evaluation ◽  
Shared Structure

Synthesis and Biological Evaluation of 1,5-Naphthyridines as Topoisomerase I Inhibitors. A New Family of Antiproliferative Agents

2015 ◽  
Vol 14 (23) ◽  
pp. 2722-2728 ◽  
Author(s):  
Concepcion Alonso ◽  
Maria Fuertes ◽  
Maria Gonzalez ◽  
Alicia Rodriguez-Gascon ◽  
Gloria Rubiales ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Biological Evaluation ◽  
Antiproliferative Agents ◽  
Topoisomerase I Inhibitors ◽  
New Family ◽  
Synthesis And Biological Evaluation

Taxol structure-activity relationships: synthesis and biological evaluation of 10-deoxytaxol

1993 ◽  
Vol 58 (11) ◽  
pp. 2927-2928 ◽  
Author(s):  
Shu Hui Chen ◽  
Craig Fairchild ◽  
Stephen W. Mamber ◽  
Vittorio Farina
Keyword(s):  
Biological Evaluation ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Synthesis And Biological Evaluation

scholarly journals The structure–activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode

2010 ◽  
Vol 18 (15) ◽  
pp. 5535-5552 ◽  
Author(s):  
Maris A. Cinelli ◽  
Andrew E. Morrell ◽  
Thomas S. Dexheimer ◽  
Keli Agama ◽  
Surbhi Agrawal ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Binding Mode ◽  
Structure Activity Relationships ◽  
Topoisomerase I Inhibitors ◽  
Structure Activity
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