The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus

2013 ◽  
Vol 23 (10) ◽  
pp. 3051-3058 ◽  
Author(s):  
Angel Guzman-Perez ◽  
Jeffrey A. Pfefferkorn ◽  
Esther C.Y. Lee ◽  
Benjamin D. Stevens ◽  
Gary E. Aspnes ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Receptor Antagonist ◽  
Glucagon Receptor ◽  
Design And Synthesis ◽  
Pharmacokinetic Properties ◽  
Glucagon Receptor Antagonist

Glucagon Receptor Antagonist LGD-6972 Significantly Lowers HbA1c and Is Well Tolerated after 12-Week Treatment in Patients with Type 2 Diabetes Mellitus (T2DM) on Metformin

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 73-OR ◽  
Author(s):  
JEREMY PETTUS ◽  
ERIC G. VAJDA ◽  
JAMES PIPKIN ◽  
GRETCHEN WILLIAMSON ◽  
MIRIAM A. ZANGMEISTER ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Receptor Antagonist ◽  
Glucagon Receptor ◽  
Glucagon Receptor Antagonist

The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of Type 2 diabetes mellitus

2012 ◽  
Vol 22 (23) ◽  
pp. 7100-7105 ◽  
Author(s):  
Jeffrey A. Pfefferkorn ◽  
Meihua Tu ◽  
Kevin J. Filipski ◽  
Angel Guzman-Perez ◽  
Jianwei Bian ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Design And Synthesis ◽  
Glucokinase Activators

scholarly journals Treatment with LY2409021, a glucagon receptor antagonist, increases liver fat in patients with type 2 diabetes

2017 ◽  
Vol 19 (11) ◽  
pp. 1521-1528 ◽  
Author(s):  
Cristina B. Guzman ◽  
Xiaotian M. Zhang ◽  
Rong Liu ◽  
Arie Regev ◽  
Sudha Shankar ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Receptor Antagonist ◽  
Liver Fat ◽  
Glucagon Receptor ◽  
Glucagon Receptor Antagonist
Sign in / Sign up

Export Citation Format

Share Document