scholarly journals Accelerating the Tempo of the Segmentation Clock by Reducing the Number of Introns in the Hes7 Gene

Cell Reports ◽  
2013 ◽  
Vol 3 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Yukiko Harima ◽  
Yoshiki Takashima ◽  
Yuriko Ueda ◽  
Toshiyuki Ohtsuka ◽  
Ryoichiro Kageyama
Keyword(s):  
Segmentation Clock ◽  
Hes7 Gene

scholarly journals No Predictable Relationship Between Presacral Vertebral Number and Hes7 Intron Number Across Mammals

2020 ◽  
Author(s):  
Patrick Arnold ◽  
Marie Gurke
Keyword(s):  
Traveling Wave ◽  
Previous Suggestion ◽  
Segmentation Clock ◽  
Evolutionary Mechanism ◽  
Vertebral Number ◽  
Direct Causal Relationship ◽  
Somite Formation ◽  
Intron Number ◽  
Cyclic Expression ◽  
Hes7 Gene

Abstract In mammals, the number of vertebrae and the somites they derive from is highly limited. Nevertheless, there are some lineages that have an increased number of presacral vertebrae and thus an elongated trunk. This suggests that somitogenesis, the process of somite formation in early development, is altered in these lineages. According the ‘clock and wavefront’ model of somitogenesis, temporal information of somite boundary formation is generated by a traveling wave of cyclic expression of oscillator genes. Hes7 has been suggested to be a key oscillator gene of this molecular segmentation clock. A previous study showed that reducing the number of introns within the Hes7 gene results in a more rapid tempo of Hes7 oscillation and an increased number of presacral vertebrae. Variation in Hes7 intron number could therefore be a potential evolutionary mechanism for varying vertebral number across mammals. In order to test this hypothesis, Hes7 intron number is here compared to presacral vertebral number across a variety of mammals.No significant relationship between both metrics could be detected as their variation across the mammalian phylogeny is fundamentally different. Integrating our data in the previously published mathematical model of Hes7 oscillation confirms the finding that variation in intron number does not predict variation in presacral vertebrae, rendering a direct causal relationship unlikely. However, our data support the previous suggestion that at least two introns are required for Hes7 pace making function of the segmentation clock.

scholarly journals 13-P072 Interfering with Wnt signalling alters the periodicity of the segmentation clock

2009 ◽  
Vol 126 ◽  
pp. S216
Author(s):  
Sarah Gibb ◽  
Kim Dale
Keyword(s):  
Wnt Signalling ◽  
Segmentation Clock

scholarly journals Notch signaling, the segmentation clock, and the patterning of vertebrate somites

2009 ◽  
Vol 8 (4) ◽  
pp. 44 ◽  
Author(s):  
Julian Lewis ◽  
Anja Hanisch ◽  
Maxine Holder
Keyword(s):  
Notch Signaling ◽  
Segmentation Clock
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