scholarly journals Sharp-Wave Ripples Orchestrate the Induction of Synaptic Plasticity during Reactivation of Place Cell Firing Patterns in the Hippocampus

Cell Reports ◽  
2016 ◽  
Vol 14 (8) ◽  
pp. 1916-1929 ◽  
Author(s):  
Josef H.L.P. Sadowski ◽  
Matthew W. Jones ◽  
Jack R. Mellor
Keyword(s):  
Synaptic Plasticity ◽  
Place Cell ◽  
Firing Patterns ◽  
Sharp Wave ◽  
Cell Firing

scholarly journals Hippocampal Place Cell Firing Patterns Can Induce Long-Term Synaptic Plasticity In Vitro

2009 ◽  
Vol 29 (21) ◽  
pp. 6840-6850 ◽  
Author(s):  
J. T. R. Isaac ◽  
K. A. Buchanan ◽  
R. U. Muller ◽  
J. R. Mellor
Keyword(s):  
Synaptic Plasticity ◽  
Place Cell ◽  
Firing Patterns ◽  
Cell Firing ◽  
Hippocampal Place Cell

Remapping of place cell firing patterns after maze rotations

2002 ◽  
Vol 143 (4) ◽  
pp. 470-479 ◽  
Author(s):  
Arnaud Cressant ◽  
Robert U. Muller ◽  
Bruno Poucet
Keyword(s):  
Place Cell ◽  
Firing Patterns ◽  
Cell Firing

scholarly journals Prefrontal Cortex Focally Modulates Hippocampal Place Cell Firing Patterns

2013 ◽  
Vol 33 (8) ◽  
pp. 3443-3451 ◽  
Author(s):  
V. Hok ◽  
E. Chah ◽  
E. Save ◽  
B. Poucet
Keyword(s):  
Prefrontal Cortex ◽  
Place Cell ◽  
Firing Patterns ◽  
Cell Firing ◽  
Hippocampal Place Cell

scholarly journals Spatial cell firing during virtual navigation of open arenas by head-restrained mice

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Guifen Chen ◽  
John Andrew King ◽  
Yi Lu ◽  
Francesca Cacucci ◽  
Neil Burgess
Keyword(s):  
Place Cell ◽  
Head Movements ◽  
Running Speed ◽  
Firing Patterns ◽  
Firing Rates ◽  
Theta Frequency ◽  
Phase Precession ◽  
Cell Firing ◽  
Theta Phase ◽  
Theta Phase Precession

We present a mouse virtual reality (VR) system which restrains head-movements to horizontal rotations, compatible with multi-photon imaging. This system allows expression of the spatial navigation and neuronal firing patterns characteristic of real open arenas (R). Comparing VR to R: place and grid, but not head-direction, cell firing had broader spatial tuning; place, but not grid, cell firing was more directional; theta frequency increased less with running speed, whereas increases in firing rates with running speed and place and grid cells' theta phase precession were similar. These results suggest that the omni-directional place cell firing in R may require local-cues unavailable in VR, and that the scale of grid and place cell firing patterns, and theta frequency, reflect translational motion inferred from both virtual (visual and proprioceptive) and real (vestibular translation and extra-maze) cues. By contrast, firing rates and theta phase precession appear to reflect visual and proprioceptive cues alone.

scholarly journals Spatial cell firing during virtual navigation of open arenas by head-restrained mice

2018 ◽  
Author(s):  
Guifen Chen ◽  
John A King ◽  
Yi Lu ◽  
Francesca Cacucci ◽  
Neil Burgess
Keyword(s):  
Translational Motion ◽  
Grid Cell ◽  
Place Cell ◽  
Head Movements ◽  
Neuronal Firing ◽  
Firing Patterns ◽  
Firing Rates ◽  
Theta Frequency ◽  
Cell Firing ◽  
Horizontal Rotations

AbstractWe present a mouse virtual reality (VR) system which restrains head-movements to horizontal rotations, potentially compatible with multi-photon imaging. We show that this system allows expression of the spatial navigational behaviour and neuronal firing patterns characteristic of real open arenas (R). Place and grid, but not head-direction, cell firing had broader spatial tuning in VR than R. Theta frequency increased less with running speed in VR than in R, while firing rates increased similarly in both. Place, but not grid, cell firing was more directional in VR than R. These results suggest that the scale of grid and place cell firing patterns, and the frequency of theta, reflect translational motion inferred from both virtual (visual and proprioceptive) cues and uncontrolled static (vestibular translation and extra-maze) cues, while firing rates predominantly reflect visual and proprioceptive motion. They also suggest that omni-directional place cell firing in R reflects local-cues unavailable in VR.

Grids from bands, or bands from grids? An examination of the effects of single unit contamination on grid cell firing fields

2016 ◽  
Vol 115 (2) ◽  
pp. 992-1002 ◽  
Author(s):  
Z. Navratilova ◽  
K. B. Godfrey ◽  
B. L. McNaughton
Keyword(s):  
Single Cell ◽  
Grid Cell ◽  
Cell Isolation ◽  
Recording Technology ◽  
Firing Patterns ◽  
Limiting Step ◽  
Isolation Methods ◽  
Single Cell Isolation ◽  
Cell Firing ◽  
Cell Data

Neural recording technology is improving rapidly, allowing for the detection of spikes from hundreds of cells simultaneously. The limiting step in multielectrode electrophysiology continues to be single cell isolation. However, this step is crucial to the interpretation of data from putative single neurons. We present here, in simulation, an illustration of possibly erroneous conclusions that may be reached when poorly isolated single cell data are analyzed. Grid cells are neurons recorded in rodents, and bats, that spike in equally spaced locations in a hexagonal pattern. One theory states that grid firing patterns arise from a combination of band firing patterns. However, we show here that summing the grid firing patterns of two poorly resolved neurons can result in spurious band-like patterns. Thus, evidence of neurons spiking in band patterns must undergo extreme scrutiny before it is accepted. Toward this aim, we discuss single cell isolation methods and metrics.

A model of cell firing patterns during epileptic seizures

1976 ◽  
Vol 22 (4) ◽  
pp. 229-234 ◽  
Author(s):  
L. K. Kaczmarek
Keyword(s):  
Epileptic Seizures ◽  
Firing Patterns ◽  
Cell Firing

scholarly journals Ripple Band Phase Precession of Place Cell Firing during Replay

2021 ◽  
Author(s):  
Daniel Bush ◽  
Freyja Olafsdottir ◽  
Caswell Barry ◽  
Neil Burgess
Keyword(s):  
Hippocampal Formation ◽  
Receptive Fields ◽  
Negative Relationship ◽  
Place Cell ◽  
Place Cells ◽  
Phase Coding ◽  
Equivalent Rate ◽  
Phase Precession ◽  
Cell Firing ◽  
Ripple Phase

Phase coding offers several theoretical advantages for information transmission compared to an equivalent rate code. Phase coding is shown by place cells in the rodent hippocampal formation, which fire at progressively earlier phases of the movement related 6-12Hz theta rhythm as their spatial receptive fields are traversed. Importantly, however, phase coding is independent of carrier frequency, and so we asked whether it might also be exhibited by place cells during 150-250Hz ripple band activity, when they are thought to replay information to neocortex. We demonstrate that place cells which fire multiple spikes during candidate replay events do so at progressively earlier ripple phases, and that spikes fired across all replay events exhibit a negative relationship between decoded location within the firing field and ripple phase. These results provide insights into the mechanisms underlying phase coding and place cell replay, as well as the neural code propagated to downstream neurons.

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