Androgen Receptor Variants and Castration-resistant Prostate Cancer: Looking Back and Looking Forward

2018 ◽  
Vol 73 (5) ◽  
pp. 724-726 ◽  
Author(s):  
Takuma Uo ◽  
Cynthia Sprenger
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant ◽  
Androgen Receptor Variants ◽  
Looking Back

scholarly journals Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer

2017 ◽  
Vol 77 (22) ◽  
pp. 6282-6298 ◽  
Author(s):  
Suriyan Ponnusamy ◽  
Christopher C. Coss ◽  
Thirumagal Thiyagarajan ◽  
Kate Watts ◽  
Dong-Jin Hwang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant ◽  
Selective Agents ◽  
Androgen Receptor Variants

scholarly journals Dissecting the roles of the androgen receptor in prostate cancer from molecular perspectives

Tumor Biology ◽  
2017 ◽  
Vol 39 (5) ◽  
pp. 101042831769225 ◽  
Author(s):  
Jieping Hu ◽  
Gongxian Wang ◽  
Ting Sun
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Progression ◽  
Protein Modification ◽  
Prostate Cancer Progression ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant ◽  
Receptor Signal ◽  
Androgen Receptor Variants ◽  
And Function

Androgen receptor plays a pivotal role in prostate cancer progression, and androgen deprivation therapy to intercept androgen receptor signal pathway is an indispensable treatment for most advanced prostate cancer patients to delay cancer progression. However, the emerging of castration-resistant prostate cancer reminds us the alteration of androgen receptor, which includes androgen receptor mutation, the formation of androgen receptor variants, and androgen receptor distribution in cancer cells. In this review, we introduce the process of androgen receptor and also its variants’ formation, translocation, and function alteration by protein modification or interaction with other pathways. We dissect the roles of androgen receptor in prostate cancer from molecular perspective to provide clues for battling prostate cancer, especially castration-resistant prostate cancer.

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