086 Biological Variability of Cardiac Troponin I in Healthy Individuals, Patients with Renal Failure Requiring Haemodialysis and Patients With Cardiomyopathy

2020 ◽  
Vol 29 ◽  
pp. S75-S76
Author(s):  
N. Lan ◽  
L. Nguyen ◽  
S. Vasikaran ◽  
C. Wilson ◽  
J. Jonsson ◽  
...  
Keyword(s):  
Renal Failure ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Biological Variability ◽  
Healthy Individuals

Short- and long-term biological variation of cardiac troponin I in healthy individuals, and patients with end-stage renal failure requiring haemodialysis or cardiomyopathy

2020 ◽  
Vol 58 (11) ◽  
pp. 1941-1949
Author(s):  
Nick S. R. Lan ◽  
Lan T. Nguyen ◽  
Samuel D. Vasikaran ◽  
Catherine Wilson ◽  
Jacqueline Jonsson ◽  
...  
Keyword(s):  
Renal Failure ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Biological Variation ◽  
Healthy Individuals ◽  
Short Term ◽  
End Stage Renal Failure ◽  
Short And Long Term ◽  
End Stage

AbstractObjectivesHigh-sensitivity (hs) cardiac troponin (cTn) assays can quantitate small fluctuations in cTn concentration. Determining biological variation allows calculation of reference change values (RCV), to define significant changes. We assessed the short- and long-term biological variation of cardiac troponin I (cTnI) in healthy individuals and patients with renal failure requiring haemodialysis or cardiomyopathy.MethodsPlasma samples were collected hourly for 4 h and weekly for seven further weeks from 20 healthy individuals, 9 renal failure patients and 20 cardiomyopathy patients. Pre- and post-haemodialysis samples were collected weekly for 7 weeks. Samples were analysed using a hs-cTnI assay (Abbott Alinity ci-series). Within-subject biological variation (CVI), analytical variation (CVA) and between-subject biological variation (CVG) was used to calculate RCVs and index of individuality (II).ResultsFor healthy individuals, CVI, CVA, CVG, RCV and II values were 8.8, 14.0, 43.1, 45.8% and 0.38 respectively for short-term, and 41.4, 14.0, 25.8, 121.0% and 1.69 for long-term. For renal failure patients, these were 2.6, 5.8, 50.5, 17.6% and 0.30 respectively for short-term, and 19.1, 5.8, 11.2, 55.2% and 1.78 for long-term. For cardiomyopathy patients, these were 4.2, 10.0, 65.9, 30.0% and 0.16 respectively for short-term, and 17.5, 10.0, 63.1, 55.8% and 0.32 for long-term. Mean cTnI concentration was lower post-haemodialysis (15.2 vs. 17.8 ng/L, p < 0.0001), with a 16.9% mean relative change.ConclusionsThe biological variation of cTnI is similar between end-stage renal failure and cardiomyopathy patients, but proportionately greater in well-selected healthy individuals with very low baseline cTnI concentrations.

Cardiac troponin-I content of skeletal muscle in patients with renal failure

2002 ◽  
Vol 35 (5) ◽  
pp. 421-423 ◽  
Author(s):  
Salim Fredericks ◽  
Kate Bainbridge ◽  
Christiane D Fenske ◽  
David Gaze ◽  
Paul O Collinson ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Renal Failure ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I

Evaluation of serum cardiac troponin I concentration in dogs with renal failure

2009 ◽  
Vol 234 (6) ◽  
pp. 767-770 ◽  
Author(s):  
Leslie C. Sharkey ◽  
Inese Berzina ◽  
Luca Ferasin ◽  
Anthony H. Tobias ◽  
Jody P. Lulich ◽  
...  
Keyword(s):  
Renal Failure ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Serum Cardiac Troponin

Cardiac troponin I is elevated in dogs and cats with azotaemia renal failure and in dogs with non-cardiac systemic disease

2008 ◽  
Vol 86 (10) ◽  
pp. 390-394 ◽  
Author(s):  
F Porciello ◽  
M Rishniw ◽  
WE Herndon ◽  
F Birettoni ◽  
MT Antognoni ◽  
...  
Keyword(s):  
Renal Failure ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Systemic Disease ◽  
Cardiac Troponin I
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