Synthesis, X-ray crystal structure, DNA/protein binding, DNA cleavage and cytotoxicity studies of N(4) substituted thiosemicarbazone based copper(II)/nickel(II) complexes
Copper(ii) complexes containing isatin thiosemicarbozone ligands have been synthesized and evaluated for its biological applications like DNA/protein binding and DNA cleavage studies.
A Cu(ii) complex, [Cu(L1Hpy)Cl]2(ClO4)2, of a tridentate pyridoxal Schiff base shows exceptionally high catalytic efficiency (kcat = 3.46 × 105 h−1) for catecholase activity in MeOH solution, the highest value reported in literature so far.