scholarly journals Activation of Invariant NKT Cells by Toll-like Receptor 9-Stimulated Dendritic Cells Requires Type I Interferon and Charged Glycosphingolipids

Immunity ◽  
2007 ◽  
Vol 27 (4) ◽  
pp. 597-609 ◽  
Author(s):  
Christophe Paget ◽  
Thierry Mallevaey ◽  
Anneliese O. Speak ◽  
David Torres ◽  
Josette Fontaine ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Type I Interferon ◽  
Nkt Cells ◽  
Type I ◽  
Toll Like Receptor ◽  
Invariant Nkt Cells

scholarly journals Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction

2009 ◽  
Vol 206 (7) ◽  
pp. 1603-1614 ◽  
Author(s):  
Wei Cao ◽  
Laura Bover ◽  
Minkwon Cho ◽  
Xiaoxia Wen ◽  
Shino Hanabuchi ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Proinflammatory Cytokines ◽  
Stromal Cell ◽  
Bone Marrow Stromal Cell ◽  
Type I Interferon ◽  
Plasmacytoid Dendritic Cells ◽  
Orphan Receptor ◽  
Receptor Interaction ◽  
Type I ◽  
Toll Like Receptor

Plasmacytoid dendritic cells (pDCs) produce copious type I interferon (IFN) upon sensing nucleic acids through Toll-like receptor (TLR) 7 and TLR9. Uncontrolled pDC activation and IFN production are implicated in lymphopenia and autoimmune diseases; therefore, a mechanism controlling pDC IFN production is essential. Human pDCs specifically express an orphan receptor, immunoglobulin-like transcript 7 (ILT7). Here, we discovered an ILT7 ligand expressed by human cell lines and identified it as bone marrow stromal cell antigen 2 (BST2; CD317). BST2 directly binds to purified ILT7 protein, initiates signaling via the ILT7–FcεRIγ complex, and strongly inhibits production of IFN and proinflammatory cytokines by pDCs. Readily induced by IFN and other proinflammatory cytokines, BST2 may modulate the human pDC’s IFN responses through ILT7 in a negative feedback fashion.

scholarly journals Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

2008 ◽  
Vol 9 (10) ◽  
pp. 1157-1164 ◽  
Author(s):  
Weiping Cao ◽  
Santhakumar Manicassamy ◽  
Hua Tang ◽  
Sudhir Pai Kasturi ◽  
Ali Pirani ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Type I Interferon ◽  
Plasmacytoid Dendritic Cells ◽  
Type I ◽  
Toll Like Receptor

scholarly journals Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells

Immunity ◽  
2011 ◽  
Vol 34 (3) ◽  
pp. 352-363 ◽  
Author(s):  
Tatsuya Saitoh ◽  
Takashi Satoh ◽  
Naoki Yamamoto ◽  
Satoshi Uematsu ◽  
Osamu Takeuchi ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Type I Interferon ◽  
Plasmacytoid Dendritic Cells ◽  
Type I ◽  
Interferon Production ◽  
Toll Like Receptor ◽  
Antiviral Protein

scholarly journals Phospholipid Scramblase 1 regulates Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells

Cell Research ◽  
2012 ◽  
Vol 22 (7) ◽  
pp. 1129-1139 ◽  
Author(s):  
Amjad H Talukder ◽  
Musheng Bao ◽  
Tae Whan Kim ◽  
Valeria Facchinetti ◽  
Shino Hanabuchi ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Type I Interferon ◽  
Plasmacytoid Dendritic Cells ◽  
Type I ◽  
Interferon Production ◽  
Toll Like Receptor ◽  
Phospholipid Scramblase ◽  
Phospholipid Scramblase 1
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