Punctate hyperreflective vitreous opacities visualized by handheld spectral domain optical coherence tomography in premature infants screened for retinopathy of prematurity

Purpose.To examine the macular findings obtained with spectral domain optical coherence tomography (SD OCT) in infants with retinopathy of prematurity (ROP).Materials and Methods.The macular SD OCT images of 190 premature infants were analyzed. Data regarding central foveal thickness (CFT), cystoid macular edema (CME), and cyst grading were compared. The relationships of CFT with gestational age and birth weight were investigated.Results.The results were obtained from 358 eyes of 179 infants (81 females and 98 males) of a mean gestational age of30.9±2.7weeks and a mean birth weight of1609±477 g. ROP was diagnosed in 126 eyes and CME in 139 eyes. A significantly greater percentage of eyes with ROP were found to have CME (54%) compared to eyes without ROP (31%;P=0.001). The incidence of CME was 46.3% for stage 1 ROP, 57.1% for stage 2, and 87.5% for stage 3. There was a weakly inverse correlation between CFT, gestational age, and birth weight (P=0.025,r=-0.227;P=0.002,r=-0.182, resp., Spearman correlation test).Conclusions.High-quality SD OCT images can be obtained from premature infants using the iVue system. Severity and frequency of CME in premature infants increase as stage of ROP increases.

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Vitreous findings quantified by handheld spectral domain optical coherence tomography correlate with retinopathy of prematurity severity

Journal of American Association for Pediatric Ophthalmology and Strabismus ◽

10.1016/j.jaapos.2021.08.016 ◽

2021 ◽

Vol 25 (4) ◽

pp. e3

Author(s):

Michelle T. Cabrera ◽

Alex T. Legocki ◽

Emily Zepeda ◽

Thomas B. Gillette ◽

Phanith Touch ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Retinopathy Of Prematurity ◽

Spectral Domain ◽

Optical Coherence

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Simultaneous Fluorescein Angiography and Spectral Domain Optical Coherence Tomography Correlate Retinal Thickness Changes to Vascular Abnormalities in an In Vivo Mouse Model of Retinopathy of Prematurity

Journal of Ophthalmology ◽

10.1155/2017/9620876 ◽

2017 ◽

Vol 2017 ◽

pp. 1-9 ◽

Cited By ~ 3

Author(s):

Olachi J. Mezu-Ndubuisi ◽

Lauren K. Taylor ◽

Jamee A. Schoephoerster

Keyword(s):

Optical Coherence Tomography ◽

Fluorescein Angiography ◽

Retinopathy Of Prematurity ◽

Retinal Thickness ◽

Vascular Development ◽

Spectral Domain ◽

Optical Coherence ◽

Vascular Abnormalities ◽

Oxygen Induced Retinopathy

Background. Retinopathy of prematurity (ROP) is a condition of abnormal retinal vascular development (RVD) in premature infants. Fluorescein angiography (FA) has depicted phases (early, mid, late, and mature) of RVD in oxygen-induced retinopathy (OIR) mice. We sought to establish the relationship between retinal structural and vascular changes using simultaneous FA and spectral domain optical coherence tomography (SD-OCT). Method. 63 mice were exposed to 77% oxygen at postnatal day 7 (P7) for 5 days, while 63 mice remained in room air (RA). Total retinal thickness (TRT), inner retinal thickness (IRT), and outer retinal thickness (ORT) were calculated at early (P19), mid (P24), late (P32), and mature (P47) phases of RVD. Results. TRT was reduced in OIR (162.66 ± 17.75 μm, n=13) compared to RA mice at P19 (197.57 ± 3.49 μm, n=14), P24, P32, and P49 (P<0.0001). ORT was similar in RA and OIR mice at all ages (P>0.05). IRT was reduced in OIR (71.60 ± 17.14 μm) compared to RA (103.07 ± 3.47 μm) mice at P19 and all ages (P<0.0001). Conclusion. We have shown the spatial and temporal relationship between retinal structure and vascular development in OIR. Significant inner retinal thinning in OIR mice persisted despite revascularization of the capillary network; further studies will elucidate its functional implications in ROP.

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