Quantitative assessment of macular microvasculature and radial peripapillary capillary plexus in the fellow eyes of patients with retinal vein occlusion using OCT angiography

2020 ◽  
Vol 43 (9) ◽  
pp. 842-850
Author(s):  
S. Ozcaliskan ◽  
Y. Ozcan
Keyword(s):  
Retinal Vein Occlusion ◽  
Quantitative Assessment ◽  
Oct Angiography ◽  
Vein Occlusion ◽  
Capillary Plexus ◽  
Radial Peripapillary Capillary ◽  
Fellow Eyes

scholarly journals Diagnostic value OF oct-angiography AND regional hemodynamic assesSment in patients with retinal vein occlusion

2017 ◽  
Vol 10 (2) ◽  
pp. 40-48 ◽  
Author(s):  
Svetlana N Tultseva ◽  
Yury S Astakhov ◽  
Aleksey G Rukhovets ◽  
Aleksandra I Titarenko
Keyword(s):  
Retinal Vein Occlusion ◽  
Vision Loss ◽  
Comprehensive Evaluation ◽  
Oct Angiography ◽  
Foveal Avascular Zone ◽  
Capillary Perfusion ◽  
Flow Area ◽  
Vein Occlusion ◽  
Hemodynamic Assessment ◽  
Capillary Plexus

Introduction. Ischemic maculopathy is the main cause of irreversible vision loss due to retinal vein occlusion (RVO). Fluorescent angiography (FA), being “golden standard” in evaluating retinal capillary plexus does not allow to visualize separately intraretinal capillary networks. Optical coherence tomography angiography (OCT-angiography) gives the possibility to visualize 4 capillary plexi and allows carrying out a quantitative analysis of microcirculation quantitatively estimating capillary network density and non-perfusion areas. Aim: to investigate microcirculation changes using OCT-angiography data and to compare them to opthalmoplethysmography indices in patients with RVO. Material and methods: The study included 12 patients with retinal vein occlusion. In all patients, routine ophthalmic examination was carried out, and additionally ocular blood flow was estimated using FA, OCT-angiography and ophthalmoplethysmography. Results: Ischemia in the macular area was detected in 4 patients (25%) according to FA results, and in 8 (67%) according to OCT-angiography data. In comparison with the unaffected eye, significant decrease in density of both superficial and deep capillary plexi, decrease in ‘flow area’ and enlargement of foveal avascular zone were observed. Significant close direct correlation was established between capillary density in the superficial capillary plexus (r > 0.8) and the deep one (r > 0.7), choroidal thickness, and opthalmoplethysmography indices (r > 0.6). Conclusion: When compared to FA, OCT-angiography is a more sensitive method to detect macular capillary perfusion. In case of retinal veins occlusion the combination of the above mentioned methods with ophthalmoplethysmography allows to perform comprehensive evaluation of the regional hemodynamics.

scholarly journals Correlation between macular edema recurrence and macular capillary network destruction in branch retinal vein occlusion

2019 ◽  
Author(s):  
Ji Hye Jang ◽  
Yu Cheol Kim ◽  
Jae Pil Shin
Keyword(s):  
Macular Edema ◽  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Capillary Network ◽  
Oct Angiography ◽  
Swept Source ◽  
Vein Occlusion ◽  
Capillary Plexus ◽  
Treatment Naïve ◽  
Recurrence Group

Abstract Purpose: To evaluate the correlation between changes of the macular capillary network and macular edema (ME) recurrence in branch retinal vein occlusion (BRVO) using swept-source optical coherence tomography (SS-OCT) angiography. Methods: We reviewed the data of 43 patients with treatment-näive ME associated with BRVO. Patients who received intravitreal bevacuzumab injection were divided into two groups based on ME recurrence after 6 months after edema resolution. The perifoveal capillary morphology and the macular capillary vessel density (VD) were retrospectively analyzed with en face SS-OCT angiography image after ME resolution. Results: In the ME recurrence group (n=22), a broken the perifoveal capillary ring in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) was more common than the no ME recurrence group (p = 0.047 and p = 0.002). The destruction of the perifoveal capillary ring of the DCP (30.0° vs 87.3°, p = 0.001) was more severe than that of the SCP (17.3° vs 69.5°, p = 0.006) in the ME recurrence group compared with the no ME recurrence group. The hemi-VD disparity between the affected areas and the unaffected areas in the SCP and DCP showed significant differences (p = 0.031 and p = 0.017), while macular VD showed no differences between the groups. Conclusions: The destroyed perifoveal capillary ring and the hemi-VD disparity were related to the recurrence of ME in BRVO. Therefore, these factors can be helpful in predicting ME recurrence.

scholarly journals Patients with unilateral retinal vein occlusion show reduced radial peripapillary capillary density in their fellow eyes

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Lingling Fan ◽  
Yazhou Zhu ◽  
Xiaomei Sun ◽  
Jinguo Yu ◽  
Hua Yan
Keyword(s):  
Retinal Vein Occlusion ◽  
Capillary Density ◽  
Fiber Layer ◽  
Vein Occlusion ◽  
Rnfl Thickness ◽  
Temporal Quadrant ◽  
Scan Pattern ◽  
Normal Controls ◽  
Radial Peripapillary Capillary ◽  
Fellow Eyes

Abstract Background To evaluate the radial peripapillary capillary (RPC) density in the fellow eyes of unilateral retinal vein occlusion (RVO) patients using optical coherence tomography angiography (OCTA), and further analyze the correlation between RPC density and peripapillary retinal nerve fiber layer (RNFL) thickness. Methods Seventy-eight unilateral RVO patients and 70 normal controls were included in the study. OCTA was conducted with the 4.5 × 4.5-mm scan pattern centered on the optic nerve head, and the RPC density and peripapillary RNFL thickness were quantified. Results The peripapillary RNFL in the RVO fellow eyes was significantly thinner than in normal controls in the average, inferior-hemisphere, inferior quadrant, and temporal quadrant (P < 0.05, respectively). The RPC density in the fellow eyes was also significantly lower in the average, inferior-hemisphere, nasal quadrant, and temporal quadrant ((P < 0.05, respectively). There were no significant differences in RNFL thickness and RPC density between branch RVO fellow eyes and central RVO fellow eyes. Pearson’s correlation analysis showed significant positive correlations between the RPC density and RNFL thickness in all measurements (P < 0.001, respectively). Conclusions The regional RPC density was reduced in the RVO fellow eyes, which might contribute to peripapillary RNFL thinning in the corresponding region, suggesting the influence of systemic risk factors on RVO. OCTA may offer new insights into the pathophysiology of RVO.

scholarly journals Evaluation of Microvascular Network with Optical Coherence Tomography Angiography (OCTA) in Branch Retinal vein Occlusion (BRVO)

2019 ◽  
Author(s):  
Lulu Chen ◽  
Mingzhen Yuan ◽  
Lu Sun ◽  
Yuelin Wang ◽  
Youxin Chen
Keyword(s):  
Optical Coherence Tomography ◽  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Microvascular Network ◽  
Vein Occlusion ◽  
Avascular Zone ◽  
Radial Peripapillary Capillary ◽  
Fellow Eyes

Abstract Purpose: To evaluate changes of microvascular network of macular and peripapillary regions and to provide a quantitative measurement of foveal avascular zone (FAZ) in unilateral BRVO patients. Methods: Forty-seven unilateral BRVO patients were enrolled. A 3*3 mm scan centered on fovea followed by a 4.5*4.5 mm scan centered on optic nerve head (ONH) were obtained in BRVO eyes and fellow eyes of each individual using OCTA (Optovue Inc., Fremont, CA, USA). Vessel density (VD) in superficial (SVC) and deep vascular complex (DVC) of macula and radial peripapillary capillary (RPC) were automatically calculated. Parameters of FAZ region including size, perimeter, acircularity index (AI) and foveal density 300 (FD-300) were measured. Results: VDs of SCV and DVC were significantly lower, especially in affected regions, in BRVO eyes compared with fellow eyes ( P <0.05). BRVO affected eyes has larger FAZ size, FAZ perimeter, AI and lower FD-300 compared with fellow eyes (all P <0.05). The average vessel density in whole area and peripapillary area in BRVO eyes were significantly lower compared with fellow eyes ( P <0.05). Conclusions: OCTA provided quantitative information of vascular changes in BRVO. FAZ in BRVO eyes showed significant morphological alterations and decreases of VD in surrounding area. Decreases of VD existed not only in SVC and DVC in macular region but also in RPCs in BRVO eyes. Key words: optical coherence tomography angiography, retinal vasculature, foveal avascular zone, radial peripapillary capillary, branch retinal vein occlusion

scholarly journals Optical coherence tomography angiography and Humphrey field analyser for macular capillary non-perfusion evaluation in branch retinal vein occlusion

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hiroko Terashima ◽  
Fumiki Okamoto ◽  
Hiruma Hasebe ◽  
Eriko Ueda ◽  
Hiromitsu Yoshida ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Field ◽  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Oct Angiography ◽  
Vein Occlusion ◽  
Field Sensitivity ◽  
Field Analyser ◽  
Capillary Plexus ◽  
The Mean

AbstractWe non-invasively evaluated macular non-perfused areas (m-NPAs) of branch retinal vein occlusion (BRVO) using optical coherence tomography (OCT) angiography and the Humphrey visual field analyser 10-2 programme (HFA 10-2). We enrolled 30 patients (30 eyes) with macular oedema secondary to BRVO. OCT angiography was used to photograph the macula at 6 × 6-mm; sizes of m-NPAs in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were measured in four areas. For HFA 10-2, we divided the actual measurement threshold of 68 points into four areas and calculated the mean central visual field sensitivity (CVFS). The correlation between the mean m-NPA and mean CVFS (dB) in each area was examined. There was a strong correlation between the m-NPA of each region detected in SCP and DCP, and the mean CVFS of each corresponding area (SCP: r = − 0.83, r = − 0.64, r = − 0.73, and r = − 0.79; DCP: r = − 0.82, r = − 0.71, r = − 0.71, and r = − 0.70), p values were < 0.001 for all. m-NPAs were associated with decreased visual field sensitivity in BRVO. Non-invasive m-NPA evaluation was possible using OCT angiography and HFA 10-2.

OCT angiography in retinal vein occlusion

2018 ◽  
Vol 60 (3) ◽  
Author(s):  
Maria C. Savastano ◽  
Marco Rispoli ◽  
Bruno Lumbroso
Keyword(s):  
Retinal Vein Occlusion ◽  
Oct Angiography ◽  
Vein Occlusion

Peripapillary Microvasculature of the Retina and Choriocapillaris in Uninvolved Fellow Eyes of Unilateral Retinal Vein Occlusion Patients

Retina ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Young Joo Park ◽  
Jiah Kim ◽  
Eun Ji Lee ◽  
Kyu Hyung Park
Keyword(s):  
Retinal Vein Occlusion ◽  
Vein Occlusion ◽  
Fellow Eyes

Fundus Fluorescein Angiography, Optical Coherence Tomography, and Optical Coherence Tomography Angiography Findings in Branch Retinal Vein Occlusion

2019 ◽  
pp. 83-87
Keyword(s):  
Optical Coherence Tomography ◽  
Fluorescein Angiography ◽  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Optical Coherence Tomography Angiography ◽  
Serous Retinal Detachment ◽  
Optical Coherence ◽  
Fundus Fluorescein Angiography ◽  
Vein Occlusion ◽  
Capillary Plexus

Even though the diagnosis depends on clinical examination, in cases with branch retinal vein occlusion (BRVO), fundus fluorescein angiography (FFA), optical coherence tomography (OCT), and optical coherence tomography angiography (OCTA) provide unique data for follow-up, management and prognosis. In FFA, delay of laminar flow phase in the involved branch, hyperfluorescence due to leakage from the vessel wall in the late phases, hypofluorescence due to the blockage by hemorrhage, and soft exudates, and hyperfluorescence due to macular edema can be detected. In OCT, macular thickening, cystic spaces, serous retinal detachment, hyperreflective dots, disorganization of the outer retinal layers – particularly the photoreceptor inner and outer segments line and the external limiting membrane – can be seen. OCTA reveals non-perfusion, particularly in the deep capillary plexus.

Prevalence of resolved paracentral acute middle maculopathy lesions in fellow eyes of patients with unilateral retinal vein occlusion

2019 ◽  
Vol 98 (1) ◽  
Author(s):  
Dmitrii S. Maltsev ◽  
Alexei N. Kulikov ◽  
Maria A. Burnasheva ◽  
Jay Chhablani
Keyword(s):  
Retinal Vein Occlusion ◽  
Vein Occlusion ◽  
Fellow Eyes
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