scholarly journals Diagnostic value OF oct-angiography AND regional hemodynamic assesSment in patients with retinal vein occlusion

2017 ◽  
Vol 10 (2) ◽  
pp. 40-48 ◽  
Author(s):  
Svetlana N Tultseva ◽  
Yury S Astakhov ◽  
Aleksey G Rukhovets ◽  
Aleksandra I Titarenko
Keyword(s):  
Retinal Vein Occlusion ◽  
Vision Loss ◽  
Comprehensive Evaluation ◽  
Oct Angiography ◽  
Foveal Avascular Zone ◽  
Capillary Perfusion ◽  
Flow Area ◽  
Vein Occlusion ◽  
Hemodynamic Assessment ◽  
Capillary Plexus

Introduction. Ischemic maculopathy is the main cause of irreversible vision loss due to retinal vein occlusion (RVO). Fluorescent angiography (FA), being “golden standard” in evaluating retinal capillary plexus does not allow to visualize separately intraretinal capillary networks. Optical coherence tomography angiography (OCT-angiography) gives the possibility to visualize 4 capillary plexi and allows carrying out a quantitative analysis of microcirculation quantitatively estimating capillary network density and non-perfusion areas. Aim: to investigate microcirculation changes using OCT-angiography data and to compare them to opthalmoplethysmography indices in patients with RVO. Material and methods: The study included 12 patients with retinal vein occlusion. In all patients, routine ophthalmic examination was carried out, and additionally ocular blood flow was estimated using FA, OCT-angiography and ophthalmoplethysmography. Results: Ischemia in the macular area was detected in 4 patients (25%) according to FA results, and in 8 (67%) according to OCT-angiography data. In comparison with the unaffected eye, significant decrease in density of both superficial and deep capillary plexi, decrease in ‘flow area’ and enlargement of foveal avascular zone were observed. Significant close direct correlation was established between capillary density in the superficial capillary plexus (r > 0.8) and the deep one (r > 0.7), choroidal thickness, and opthalmoplethysmography indices (r > 0.6). Conclusion: When compared to FA, OCT-angiography is a more sensitive method to detect macular capillary perfusion. In case of retinal veins occlusion the combination of the above mentioned methods with ophthalmoplethysmography allows to perform comprehensive evaluation of the regional hemodynamics.

scholarly journals Microvascular comparison in younger and older patients with retinal vein occlusion analyzed by OCT angiography

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Panpan Ye ◽  
Tiepei Zhu ◽  
Fang Zheng ◽  
Min Zhou ◽  
Xiaoyun Fang ◽  
...  
Keyword(s):  
Retinal Vein Occlusion ◽  
Older Patients ◽  
Young Patients ◽  
Visual Outcome ◽  
Oct Angiography ◽  
Foveal Avascular Zone ◽  
Vein Occlusion ◽  
Anti Vegf ◽  
Retinal Microvasculature ◽  
Group A

Abstract Background To compare changes in retinal microvasculature of young and elderly patients with retinal vein occlusion (RVO) after anti-VEGF treatment. Methods RVO patients who underwent anti-VEGF treatment were retrospectively reviewed and categorized into two groups based on age. The OCT angiography images were obtained during each visit. Best corrected visual acuity (BCVA), vessel density (VD) and foveal avascular zone (FAZ) were measured and compared between the two groups. Vision improvements and retinal microvasculature changes were also correlated. Results Twenty patients with 20 eyes were enrolled in the younger group and 46 patients with 46 eyes were enrolled in the older group. Younger patients demonstrated better BCVA, higher VD and smaller FAZ than older patients at 12 months after the first anti-VEGF treatment. The improvement of VD was observed only in the younger group. A positive correlation between vision improvement and VD increase was noted. Conclusions Young patients with RVO can achieve rapid rehabilitation of deep retinal vasculature which lead to a better visual outcome.

scholarly journals Correlation between the Nonperfusion Area on Ultra-Widefield Fluorescein Angiography and Nonflow Area on Optical Coherence Tomographic Angiography in Retinal Vein Occlusion

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Jianfeng Huang ◽  
Yingyi Lu ◽  
Xiaoya Gu ◽  
Bodi Zheng ◽  
Tong Chen
Keyword(s):  
Fluorescein Angiography ◽  
Retinal Vein Occlusion ◽  
Statistical Testing ◽  
Foveal Avascular Zone ◽  
Peripheral Retina ◽  
Optical Coherence ◽  
Vein Occlusion ◽  
Capillary Plexus ◽  
Temporal Quadrant ◽  
Tomographic Angiography

Aims. To compare the relationship between the nonperfusion area (NPA) on ultra-widefield fluorescein angiography (UWFFA) and the nonflow area (NFA) on optical coherence tomographic angiography (OCTA) in retinal vein occlusion (RVO). Methods. Cross-sectional study. 46 eyes of 46 RVO patients who underwent UWFFA and OCTA. NPA and ischemic index (ISI) were quantified on UWWFA. NFA, vessel density (VD) of the superficial capillary plexus (SCP), the deep capillary plexus (DCP), and the size foveal avascular zone (FAZ) on 3 ∗ 3 mm OCTA were measured. The association of the NPA and ISI on UWWFA and the parameters on OCTA were analyzed. Spearman correlation was used for statistical testing. Results. The NPA and ISI on UWFFA were significantly correlated with the NFA on OCTA in RVO, and r values were 0.688 ( p < 0.01 ) and 0.680 ( p < 0.01 ), respectively. VD in the SCP of the temporal quadrant was negatively correlated with NPA and ISI, and r values were −0.346 ( p < 0.05 ) and −0.337 ( p < 0.05 ), respectively. VD in the DCP of the temporal quadrant was negatively correlated with the NPA, and the r value was −0.246 ( p < 0.05 ). No significant correlation was found between the NPA and ISI on UWFFA and VD of other quadrants in the SCP or DCP and the FAZ area on OCTA. Conclusion. NPA in the peripheral retina was correlated with NFA in macula. NFA detected by OCTA could be an indicator of the ischemic status in RVO.

scholarly journals Correlation between macular edema recurrence and macular capillary network destruction in branch retinal vein occlusion

2019 ◽  
Author(s):  
Ji Hye Jang ◽  
Yu Cheol Kim ◽  
Jae Pil Shin
Keyword(s):  
Macular Edema ◽  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Capillary Network ◽  
Oct Angiography ◽  
Swept Source ◽  
Vein Occlusion ◽  
Capillary Plexus ◽  
Treatment Naïve ◽  
Recurrence Group

Abstract Purpose: To evaluate the correlation between changes of the macular capillary network and macular edema (ME) recurrence in branch retinal vein occlusion (BRVO) using swept-source optical coherence tomography (SS-OCT) angiography. Methods: We reviewed the data of 43 patients with treatment-näive ME associated with BRVO. Patients who received intravitreal bevacuzumab injection were divided into two groups based on ME recurrence after 6 months after edema resolution. The perifoveal capillary morphology and the macular capillary vessel density (VD) were retrospectively analyzed with en face SS-OCT angiography image after ME resolution. Results: In the ME recurrence group (n=22), a broken the perifoveal capillary ring in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) was more common than the no ME recurrence group (p = 0.047 and p = 0.002). The destruction of the perifoveal capillary ring of the DCP (30.0° vs 87.3°, p = 0.001) was more severe than that of the SCP (17.3° vs 69.5°, p = 0.006) in the ME recurrence group compared with the no ME recurrence group. The hemi-VD disparity between the affected areas and the unaffected areas in the SCP and DCP showed significant differences (p = 0.031 and p = 0.017), while macular VD showed no differences between the groups. Conclusions: The destroyed perifoveal capillary ring and the hemi-VD disparity were related to the recurrence of ME in BRVO. Therefore, these factors can be helpful in predicting ME recurrence.

scholarly journals Evaluation of Microvascular Structure Changes after Conbercept Treatment on Macular Edema Secondary to Retinal Vein Occlusion

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Wenqi Song ◽  
Wanzhen Jiao ◽  
Fengjiao Li ◽  
Aihua Ma ◽  
Bojun Zhao
Keyword(s):  
Macular Edema ◽  
Intravitreal Injection ◽  
Retinal Vein Occlusion ◽  
Therapeutic Efficacy ◽  
Foveal Avascular Zone ◽  
Vascular Density ◽  
Vein Occlusion ◽  
Structure Changes ◽  
Significant Difference ◽  
Capillary Plexus

Aims. To confirm the therapeutic efficacy of conbercept for the treatment of macular edema (ME) secondary to retinal vein occlusion (RVO) by using optical coherence tomography angiography (OCTA) and to find out the differences in therapeutic efficacy between ischemic and nonischemic retinal vein occlusion (iRVO or non-iRVO) after conbercept treatment. Methods. In this prospective, randomized, and comparative study, 60 unilateral eyes suffered from RVO combined with macular edema were included and fellow eye as controls. After an initial intravitreal injection of conbercept (IVIC), a pro re nata (PRN) strategy was adopted, and the follow-up time was 6 months. The foveal avascular zone (FAZ), vascular density of superficial capillary plexus (SCP), and vascular density of deep retinal capillary plexus (DCP), nonperfused areas (NPAs) were evaluated with OCTA on baseline and after treatment. Results. The mean intravitreal injection number was 2.9±0.89 times during six months in iRVO patients and 2.1±0.86 times in non-iRVO patients, with statistically significant difference (p<0.05). On baseline, central macular thickness (CMT) and FAZ were significantly thickened and enlarged compared to those of healthy fellow eyes; the vascular density of SCP and DCP were significantly decreased, and the differences were statistically significant (p<0.05). Compared to baseline, after treatment, the best-corrected visual acuity (BCVA) was improved in either iRVO or non-iRVO (−0.601±0.387, −0.241±0.341 logMAR, p<0.05). In iRVO, the improvement was more substantial than that of the non-iRVO group. FAZ in the non-iRVO group had significantly decreased compared to that in iRVO group (−0.044±0.040 versus 0.014±0.043 mm2, p<0.05). CMT, the vascular density of SCP, and DCP had no significant difference. Conclusions. The changes of microvascular structure can be quantitatively evaluated by using OCTA for the patients with RVO. Conbercept had a significant effect on treatment of RVO with macular edema. A more profound effect was achieved in the iRVO group on visual improvement and FAZ reduction in the non-iRVO group after conbercept treatment.

Optical Coherence Tomography Angiography in Retinal Vein Occlusion: Correlation between Foveal Avascular Zone Area and Visual Acuity

2021 ◽  
Vol 37 (3) ◽  
Author(s):  
Lubna Feroz ◽  
Najia Uzair ◽  
Mariam Shamim ◽  
Shahab ul Hassan Siddiqui ◽  
Syed Asad Mehmood
Keyword(s):  
Visual Acuity ◽  
Observational Study ◽  
Macular Edema ◽  
Retinal Vein Occlusion ◽  
Foveal Avascular Zone ◽  
P Value ◽  
Optical Coherence ◽  
Vein Occlusion ◽  
Avascular Zone ◽  
Capillary Plexus

Purpose:  To find out correlation between visual acuity and deep capillary plexus (DCP) in foveal avascular zone (FAZ) area using OCTA in patients with retinal vein occlusion (RVO). Study Design:  Descriptive observational study. Place and Duration of Study:  Layton Rehmatullah Benevolent trust free Eye Hospital, from September 2018 to December 2019. Methods:  This observational study included 50 eyes of 50 patients, who were treated with intra-vitreal anti-VEGF for macular edema secondary to retinal vein occlusion. We excluded patients with macular edema due to other ocular diseases. OCTA was performed in every patient to measure the size of foveal avascular zone. FAZ area of 0.6mm2 or less was taken as normal and any value above that was considered to be larger FAZ. IBM SPSS version 25 was used to analyze the data. Frequencies with percentages were used to present qualitative variables and mean ± SD were calculated for the quantitative variables. P-value ? 0.005 was taken as significant. Results:  Mean age was 58.38 ± 7.51 years. There were 28 males and 22 females. Mean best-corrected visual acuity was 0.62 ± 0.26 logMar. The patients with normal FAZ area in DCP showed a mean BCVA of 0.51 ± 0.265 logMAR in comparison to those who had larger FAZ in DCP, where the mean BCVA was 0.75 ± 0.204 logMAR. DCP was larger in patients with CRVO than BRVO. Conclusion:  OCTA is a good diagnostic tool for qualitative and quantitative evaluation of the deep capillary plexus. Improvement in visual acuity is related with the size of the DCP in FAZ. Key Words:  Retinal vein occlusion, Foveal avascular zone, Optical Coherence Tomograghy Angiography.

scholarly journals Optical coherence tomography angiography and Humphrey field analyser for macular capillary non-perfusion evaluation in branch retinal vein occlusion

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hiroko Terashima ◽  
Fumiki Okamoto ◽  
Hiruma Hasebe ◽  
Eriko Ueda ◽  
Hiromitsu Yoshida ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Field ◽  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Oct Angiography ◽  
Vein Occlusion ◽  
Field Sensitivity ◽  
Field Analyser ◽  
Capillary Plexus ◽  
The Mean

AbstractWe non-invasively evaluated macular non-perfused areas (m-NPAs) of branch retinal vein occlusion (BRVO) using optical coherence tomography (OCT) angiography and the Humphrey visual field analyser 10-2 programme (HFA 10-2). We enrolled 30 patients (30 eyes) with macular oedema secondary to BRVO. OCT angiography was used to photograph the macula at 6 × 6-mm; sizes of m-NPAs in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were measured in four areas. For HFA 10-2, we divided the actual measurement threshold of 68 points into four areas and calculated the mean central visual field sensitivity (CVFS). The correlation between the mean m-NPA and mean CVFS (dB) in each area was examined. There was a strong correlation between the m-NPA of each region detected in SCP and DCP, and the mean CVFS of each corresponding area (SCP: r = − 0.83, r = − 0.64, r = − 0.73, and r = − 0.79; DCP: r = − 0.82, r = − 0.71, r = − 0.71, and r = − 0.70), p values were < 0.001 for all. m-NPAs were associated with decreased visual field sensitivity in BRVO. Non-invasive m-NPA evaluation was possible using OCT angiography and HFA 10-2.

OCT angiography in retinal vein occlusion

2018 ◽  
Vol 60 (3) ◽  
Author(s):  
Maria C. Savastano ◽  
Marco Rispoli ◽  
Bruno Lumbroso
Keyword(s):  
Retinal Vein Occlusion ◽  
Oct Angiography ◽  
Vein Occlusion

Creation of retinal vein occlusion model in cynomolgusmonkeys and determination of its pathological features

2020 ◽  
Vol 17 ◽  
Author(s):  
Satoshi Inagaki ◽  
Masamitsu Shimazawa ◽  
Wataru Otsu ◽  
Tomoaki Araki ◽  
Yosuke Numata ◽  
...  
Keyword(s):  
Growth Factors ◽  
Retinal Vein Occlusion ◽  
Vascular System ◽  
Retinal Thickness ◽  
Chronic Phase ◽  
Vascular Leakage ◽  
Foveal Avascular Zone ◽  
Retinal Edema ◽  
Vein Occlusion ◽  
Angiopoietin 2

Objective: A retinal vein occlusion (RVO) is a relatively common retinal vascular disorder especially in the elder-ly. Many experiments have been performed on patients with a RVO but performing any type of experiments and especially longitudinal experiments on humans is difficult if not impossible on ethical grounds. Therefore, we have created a retinal vein occlusion (RVO) model by laser irradiation of cynomolgus monkeysafter an intravenous injection of rose bengal. Weevaluated the pathological changes of the retina, and the effects of ranibizumab, an anti-vascular endothelial growth factor (VEGF) antibody, on the characteristics of the RVO. Methods: The integrity of the vascular system was evaluated by fluorescein angiography (FA), and the retinal thickness and volume were determined by optical coherence tomography (OCT). The cytokines and growth factors in the aqueous humor were identified by multiplex profiling. Results: Our results showed that ranibizumab decreased the degree of vascular leakage and retinal edema at 1-3 days (acute phase) and 3-7 days (subacute phase), and suppressed foveal thinning at 28-42 days (chronic phase) after the laser irradia-tion. Ranibizumab also decreased the area of the foveal avascular zone, and the area was negatively and significantly corre-lated with the thickness of the ganglion cell layer (GCL) complex. Furthermore, ranibizumab reduced the increased expres-sion of VEGF in the aqueous humour, but did not affect the expressions of interleukin-6 (IL-6), monocyte chemotactic pro-tein-1 (MCP-1), angiopoietin-1 (ANG-1), or angiopoietin-2 (ANG-2).Thesefindings suggest that ranibizumab attenuates the retinal edema and subsequent retinal atrophy in partby neutralizing VEGF. However, other cytokines and growth factors were also affected by the ranibizumab which suggests that not only VEGF but also other unidentified agents might play a role in the pathogenesis of the RVO. Conclusion: We have created a non-human primate RVO model, which resembles the clinical RVO pathology. In this model, an injection of ranibizumab leads to a reduction in the vascular leakage and the retinal thickness and volume by blockingthe expression of VEGF. Our model might be useful for investigating the pathological mechanisms of RVOs and explore new therapeutic agents for RVO.

Retinal obliterative vasculitis associated to contralateral retinal neovascularization in membranoproliferative glomerulonephritis

2021 ◽  
pp. 112067212110143
Author(s):  
Michele Nicolai ◽  
Alessandro Franceschi ◽  
Nicola Vito Lassandro ◽  
Paolo Pelliccioni ◽  
Luca Danieli ◽  
...  
Keyword(s):  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Membranoproliferative Glomerulonephritis ◽  
Vision Loss ◽  
Vascular Occlusion ◽  
Retinal Neovascularization ◽  
Vein Occlusion ◽  
Retinal Vascular Occlusion ◽  
Contralateral Eye ◽  
Peculiar Case

Purpose: To report our experience with a peculiar case of asynchronous bilateral retinal vascular occlusion in a patient suffering from membranoproliferative glomerulonephritis. Case report: A 57-year-old dialysed male affected by membranoproliferative glomerulonephritis who underwent kidney transplantation complained of a sudden vision loss in his right eye (RE). His best-corrected visual acuity (BCVA) was 20/40 in RE and 20/20 in the left eye (LE); ophthalmological and fluorangiographic examinations revealed unilateral retinal obliterative vasculitis with panuveitis and apparent sparing of contralateral eye. About 6 months later the patient developed a branch retinal vein occlusion associated with a papillary neovascular membrane in LE. Corticosteroid therapy was administered and immunosuppressant dosage was increased with macular oedema reduction in both events. Conclusion: We report a case of unilateral retinal obliterative vasculitis and subsequent contralateral retinal neovascularization and branch retinal vein occlusion in a patient affected by membranoproliferative glomerulonephritis.

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