BACKGROUND: Knee strength weakness is a major problem frequently observed in patients during postoperative rehabilitation following anterior cruciate ligament reconstruction (ACLR). OBJECTIVE: To investigate whether knee strength normalized to muscle volume could better detect side-to-side differences than that normalized to body weight following ACLR. METHOD: This study included 17 patients who had undergone primary ACLR (11.6 ± 2.3 months). Body weight and total muscle volume were measured using a bioelectrical impedance analysis composition scale. Isokinetic knee extension and flexion moment were measured at 60∘/s and 180∘/s, respectively. Bivariate correlation analysis was used to examine correlations between body composition and knee strength. Differences in knee strength between the operated and unoperated legs were analyzed using a paired t-test, which calculated the effect size. RESULTS: There was a significant correlation between knee strength and body weight (r= 0.53–0.67); however, a stronger correlation was observed between knee strength and total muscle volume (ρ= 0.80–0.87). The effect size was larger for knee strength expressed as % total muscle volume than for knee strength expressed as % body weight. CONCLUSION: Strength expressed as % total muscle volume may be more accurate than that expressed as % body weight for detecting side-to-side differences in knee strength following ACLR.