Metabolic channeling: predictions, deductions, and evidence

2021 ◽  
Vol 81 (18) ◽  
pp. 3775-3785
Author(s):  
Vidhi Pareek ◽  
Zhou Sha ◽  
Jingxuan He ◽  
Ned S. Wingreen ◽  
Stephen J. Benkovic
Keyword(s):  
Metabolic Channeling

Scanning Tunneling Microscopy and Atomic Force Microscopy of Enzymes and Enzyme Complexes

1990 ◽  
Vol 48 (3) ◽  
pp. 174-175
Author(s):  
Ronald D. Edstrom ◽  
Xiuru Yang ◽  
Mary E. Gurnack ◽  
Marcia A. Miller ◽  
Rui Yang ◽  
...  
Keyword(s):  
Cell Biology ◽  
Inorganic Ions ◽  
Bulk Liquid ◽  
Soluble Form ◽  
Scanning Tunneling ◽  
Tunneling Microscopy ◽  
Metabolic Channeling ◽  
Simplistic Notion ◽  
Soluble Enzymes

Many of the questions in biochemistry and cell biology are concerned with the relationships of proteins and other macromolecules in complex arrays which are responsible for carrying out metabolic sequences. The simplistic notion that the enzymes we isolate in soluble form from the cytoplasm were also soluble in vivo is being replaced by the concept that these enzymes occur in organized systems within the cell. In this newer view, the cytoplasm is organized and the “soluble enzymes” are in fact fixed in the cellular space and the only soluble components of the cell are small metabolites, inorganic ions etc. Further support for the concept of metabolic organization is provided by the evidence of metabolic channeling. It has been shown that for some metabolic pathways, the intermediates are not in free diffusion equilibrium with the bulk liquid in the cell but are passed along, more or less directly, from one enzyme to the next.

Metabolon formation and metabolic channeling in the biosynthesis of plant natural products

2005 ◽  
Vol 8 (3) ◽  
pp. 280-291 ◽  
Author(s):  
Kirsten Jørgensen ◽  
Anne Vinther Rasmussen ◽  
Marc Morant ◽  
Allan Holm Nielsen ◽  
Nanna Bjarnholt ◽  
...  
Keyword(s):  
Natural Products ◽  
Metabolic Channeling ◽  
Plant Natural Products

scholarly journals Metabolic Channeling Using DNA as a Scaffold

2018 ◽  
pp. 237-259
Author(s):  
Mojca Benčina ◽  
Jerneja Mori ◽  
Rok Gaber ◽  
Roman Jerala
Keyword(s):  
Metabolic Channeling

scholarly journals Construction of Metabolic Channeling through Interface Design of Protein Scaffold

2014 ◽  
Vol 86 (9) ◽  
pp. 1424-1424
Author(s):  
A.-P. Zeng ◽  
C.-W. Ma ◽  
A. Trautwein-Schult
Keyword(s):  
Interface Design ◽  
Protein Scaffold ◽  
Metabolic Channeling

scholarly journals Enzyme clustering accelerates processing of intermediates through metabolic channeling

2014 ◽  
Vol 32 (10) ◽  
pp. 1011-1018 ◽  
Author(s):  
Michele Castellana ◽  
Maxwell Z Wilson ◽  
Yifan Xu ◽  
Preeti Joshi ◽  
Ileana M Cristea ◽  
...  
Keyword(s):  
Metabolic Channeling

scholarly journals Cell Compartmentation and Metabolic Channeling

1981 ◽  
Vol 23 (5) ◽  
pp. 375-375
Author(s):  
Z. Opatrný
Keyword(s):  
Metabolic Channeling

Metabolic “channeling” and cellular physiology

1991 ◽  
Vol 152 (1) ◽  
pp. 29-33 ◽  
Author(s):  
G.R. Welch ◽  
P.R. Marmillot
Keyword(s):  
Metabolic Channeling ◽  
Cellular Physiology
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