scholarly journals Developmental regulation of nicotinic acetylcholine receptors within midbrain dopamine neurons

Neuroscience ◽  
2007 ◽  
Vol 144 (4) ◽  
pp. 1347-1360 ◽  
Author(s):  
L. Azam ◽  
Y. Chen ◽  
F.M. Leslie
Keyword(s):  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Developmental Regulation ◽  
Dopamine Neurons ◽  
Nicotinic Acetylcholine ◽  
Midbrain Dopamine ◽  
Midbrain Dopamine Neurons

scholarly journals In Vivo Activation of Midbrain Dopamine Neurons via Sensitized, High-Affinity α6∗ Nicotinic Acetylcholine Receptors

Neuron ◽  
2008 ◽  
Vol 60 (1) ◽  
pp. 123-136 ◽  
Author(s):  
Ryan M. Drenan ◽  
Sharon R. Grady ◽  
Paul Whiteaker ◽  
Tristan McClure-Begley ◽  
Sheri McKinney ◽  
...  
Keyword(s):  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Dopamine Neurons ◽  
Nicotinic Acetylcholine ◽  
High Affinity ◽  
Midbrain Dopamine ◽  
Midbrain Dopamine Neurons

scholarly journals Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Romain Durand-de Cuttoli ◽  
Sarah Mondoloni ◽  
Fabio Marti ◽  
Damien Lemoine ◽  
Claire Nguyen ◽  
...  
Keyword(s):  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Direct Evidence ◽  
Dynamic Range ◽  
Dopamine Neurons ◽  
Optical Manipulation ◽  
Chemical Genetic ◽  
Brain Circuits ◽  
Midbrain Dopamine ◽  
Firing Properties

Dopamine (DA) neurons of the ventral tegmental area (VTA) integrate cholinergic inputs to regulate key functions such as motivation and goal-directed behaviors. Yet the temporal dynamic range and mechanism of action of acetylcholine (ACh) on the modulation of VTA circuits and reward-related behaviors are not known. Here, we used a chemical-genetic approach for rapid and precise optical manipulation of nicotinic neurotransmission in VTA neurons in living mice. We provide direct evidence that the ACh tone fine-tunes the firing properties of VTA DA neurons through β2-containing (β2*) nicotinic ACh receptors (nAChRs). Furthermore, locally photo-antagonizing these receptors in the VTA was sufficient to reversibly switch nicotine reinforcement on and off. By enabling control of nicotinic transmission in targeted brain circuits, this technology will help unravel the various physiological functions of nAChRs and may assist in the design of novel therapies relevant to neuropsychiatric disorders.

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