Whole-body distribution and radiation dosimetry of the dopamine transporter radioligand [11C]PE2I in healthy volunteers

2007 ◽  
Vol 34 (4) ◽  
pp. 465-470 ◽  
Author(s):  
Maria-João Ribeiro ◽  
Marcel Ricard ◽  
Marie-Angele Lièvre ◽  
Sandrine Bourgeois ◽  
Patrick Emond ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Dopamine Transporter ◽  
Radiation Dosimetry ◽  
Whole Body ◽  
Body Distribution

scholarly journals Human Biodistribution and Radiation Dosimetry of the P-Glycoprotein Radiotracer [11C]Metoclopramide

2021 ◽  
Author(s):  
Martin Bauer ◽  
Sandra Barna ◽  
Matthias Blaickner ◽  
Konstantin Prosenz ◽  
Karsten Bamminger ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Healthy Volunteers ◽  
Effective Dose ◽  
Left Kidney ◽  
Whole Body ◽  
Red Bone Marrow ◽  
Body Distribution ◽  
P Glycoprotein ◽  
Pet Tracer ◽  
Male Subjects

Abstract Purpose To assess in healthy volunteers the whole-body distribution and dosimetry of [11C]metoclopramide, a new positron emission tomography (PET) tracer to measure P-glycoprotein activity at the blood-brain barrier. Procedures Ten healthy volunteers (five women, five men) were intravenously injected with 387 ± 49 MBq of [11C]metoclopramide after low dose CT scans and were then imaged by whole-body PET scans from head to upper thigh over approximately 70 min. Ten source organs (brain, thyroid gland, right lung, myocardium, liver, gall bladder, left kidney, red bone marrow, muscle and the contents of the urinary bladder) were manually delineated on whole-body images. Absorbed doses were calculated with QDOSE (ABX-CRO) using the integrated IDAC-Dose 2.1 module. Results The majority of the administered dose of [11C]metoclopramide was taken up into the liver followed by urinary excretion and, to a smaller extent, biliary excretion of radioactivity. The mean effective dose of [11C]metoclopramide was 1.69 ± 0.26 μSv/MBq for female subjects and 1.55 ± 0.07 μSv/MBq for male subjects. The two organs receiving the highest radiation doses were the urinary bladder (10.81 ± 0.23 μGy/MBq and 8.78 ± 0.89 μGy/MBq) and the liver (6.80 ± 0.78 μGy/MBq and 4.91 ± 0.74 μGy/MBq) for female and male subjects, respectively. Conclusions [11C]Metoclopramide showed predominantly renal excretion, and is safe and well tolerated in healthy adults. The effective dose of [11C]metoclopramide was comparable to other 11C-labeled PET tracers.

scholarly journals [11C]Elacridar as a novel P-glycoprotein PET tracer, assessment of whole-body distribution and radiation dosimetry in humans

2011 ◽  
Vol 11 (Suppl 2) ◽  
pp. A46
Author(s):  
Martin Bauer ◽  
Markus Zeitlinger ◽  
Georg Dobrozemsky ◽  
Cécile Philippe ◽  
Markus Müller ◽  
...  
Keyword(s):  
Radiation Dosimetry ◽  
Whole Body ◽  
Body Distribution ◽  
P Glycoprotein ◽  
Pet Tracer

scholarly journals Whole-Body Distribution and Radiation Dosimetry of 11C-Elacridar and 11C-Tariquidar in Humans

2016 ◽  
Vol 57 (8) ◽  
pp. 1265-1268 ◽  
Author(s):  
M. Bauer ◽  
M. Blaickner ◽  
C. Philippe ◽  
W. Wadsak ◽  
M. Hacker ◽  
...  
Keyword(s):  
Radiation Dosimetry ◽  
Whole Body ◽  
Body Distribution

scholarly journals Whole-Body Distribution and Radiation Dosimetry of 11C-(+)-PHNO, a D2/3 Agonist Ligand

2012 ◽  
Vol 53 (11) ◽  
pp. 1802-1806
Author(s):  
R. Mizrahi ◽  
P. Rusjan ◽  
I. Vitcu ◽  
A. Ng ◽  
A. A. Wilson ◽  
...  
Keyword(s):  
Radiation Dosimetry ◽  
Whole Body ◽  
Body Distribution

scholarly journals Whole-body biodistribution and radiation dosimetry estimates for the PET dopamine transporter probe 18F-FECNT in non-human primates

2004 ◽  
Vol 25 (7) ◽  
pp. 737-742 ◽  
Author(s):  
Dnyanesh N. Tipre ◽  
Masahiro Fujita ◽  
Frederick T. Chin ◽  
Nicholas Seneca ◽  
Douglas Vines ◽  
...  
Keyword(s):  
Dopamine Transporter ◽  
Radiation Dosimetry ◽  
Whole Body

Whole-body distribution and radiation dosimetry of [11C]telmisartan as a biomarker for hepatic organic anion transporting polypeptide (OATP) 1B3

2012 ◽  
Vol 39 (6) ◽  
pp. 847-853 ◽  
Author(s):  
Keiji Shimizu ◽  
Tadayuki Takashima ◽  
Tomohiko Yamane ◽  
Masahiro Sasaki ◽  
Hiromitsu Kageyama ◽  
...  
Keyword(s):  
Radiation Dosimetry ◽  
Organic Anion ◽  
Whole Body ◽  
Organic Anion Transporting Polypeptide ◽  
Body Distribution
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