Sequential observation of movement disorders and brain images in the case of central pontine myelinolysis and extrapontine myelinolysis

2006 ◽  
Vol 12 (7) ◽  
pp. 462-464 ◽  
Author(s):  
Jung Im Seok ◽  
Jinyoung Youn ◽  
Eun Joo Chung ◽  
Won Yong Lee
2007 ◽  
Vol 18 (2) ◽  
pp. 131-134 ◽  
Author(s):  
Jung Im Seok ◽  
Dong Kuck Lee ◽  
Min Gu Kang ◽  
Jae Han Park

Central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM) are well recognized syndromes related to the rapid correction of hyponatremia, which are reported to show brain stem signs and various movement disorders. Cognitive dysfunction and neuropsychological findings, however, have seldom been reported. Cognitive manifestations in osmotic myelinolysis may have been underestimated due to the prominent brain stem symptoms and movement disorders. We report a case of EPM without CPM and describe the neuropsychological findings of EPM. The absence of CPM in this case made it possible to test neuropsychological function in the acute stage.Neuropsychological testing showed severe impairment of attention, verbal and visual memory, visuospatial function, and frontal/executive function. Language and language-related functions were normal except naming.


1992 ◽  
Vol 7 (2) ◽  
pp. 142-148 ◽  
Author(s):  
Demetrius M. Maraganore ◽  
W. Neath Folger ◽  
Jerry W. Swanson ◽  
J. Eric Ahlskog

Author(s):  
E. M. Sheveleva ◽  
L. G. Zaslavskii ◽  
A. G. Kovelenov ◽  
E. A. Skorniakova

Central pontine myelinolysis (CPM) is a concentrated, symmetric, non-inflammatory demyelination within the central basis pontis. In 10 % of patients with СРМ, demyelination also occurs in extrapontine regions: the mid brain, thalamus, basal nuclei, and cerebellum. Demyelination occurs in regions of compact interdigitation of white and gray matter as a result of cellular edema, which is caused by fluctuating osmotic forces, results in compression of fiber tracts. The most frequent cause of abrupt change in osmotic pressure is the rapid sodium correction of prolonged hyponatremia. In case that we report, there is a combination of central pontine and extrapontine myelinolysis, which occurs in 71-year-old woman owing to rapid sodium correction of prolonged hyponatremia which by turn developed due to salt-free diet, improper antihypertensive therapy and overheating. The diagnosis was confirmed by magnetic resonance imaging (MRI). The treatment led to significant decrease of neurological deficit.


Sign in / Sign up

Export Citation Format

Share Document