Discriminative subspace matrix factorization for multiview data clustering

2021 ◽  
Vol 111 ◽  
pp. 107676 ◽  
Author(s):  
Jiaqi Ma ◽  
Yipeng Zhang ◽  
Lefei Zhang
Author(s):  
Yinlei Hu ◽  
Bin Li ◽  
Falai Chen ◽  
Kun Qu

Abstract Unsupervised clustering is a fundamental step of single-cell RNA sequencing data analysis. This issue has inspired several clustering methods to classify cells in single-cell RNA sequencing data. However, accurate prediction of the cell clusters remains a substantial challenge. In this study, we propose a new algorithm for single-cell RNA sequencing data clustering based on Sparse Optimization and low-rank matrix factorization (scSO). We applied our scSO algorithm to analyze multiple benchmark datasets and showed that the cluster number predicted by scSO was close to the number of reference cell types and that most cells were correctly classified. Our scSO algorithm is available at https://github.com/QuKunLab/scSO. Overall, this study demonstrates a potent cell clustering approach that can help researchers distinguish cell types in single-cell RNA sequencing data.


Author(s):  
Jiaqi Ma ◽  
Yipeng Zhang ◽  
Lefei Zhang ◽  
Bo Du ◽  
Dapeng Tao

Non-negative Matrix Factorization (NMF) and spectral clustering have been proved to be efficient and effective for data clustering tasks and have been applied to various real-world scenes. However, there are still some drawbacks in traditional methods: (1) most existing algorithms only consider high-dimensional data directly while neglect the intrinsic data structure in the low-dimensional subspace; (2) the pseudo-information got in the optimization process is not relevant to most spectral clustering and manifold regularization methods. In this paper, a novel unsupervised matrix factorization method, Pseudo Supervised Matrix Factorization (PSMF), is proposed for data clustering. The main contributions are threefold: (1) to cluster in the discriminant subspace, Linear Discriminant Analysis (LDA) combines with NMF to become a unified framework; (2) we propose a pseudo supervised manifold regularization term which utilizes the pseudo-information to instruct the regularization term in order to find subspace that discriminates different classes; (3) an efficient optimization algorithm is designed to solve the proposed problem with proved convergence. Extensive experiments on multiple benchmark datasets illustrate that the proposed model outperforms other state-of-the-art clustering algorithms.


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