scholarly journals Regional cerebral blood flow and cellular environment in subarachnoid hemorrhage: A thermal doppler flowmetry and microdialysis study

2017 ◽  
Vol 51 (1) ◽  
pp. 66-71 ◽  
Author(s):  
D. Papadopoulos ◽  
A. Filippidis ◽  
G. Krommidas ◽  
G. Vretzakis ◽  
K. Paterakis ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Subarachnoid Hemorrhage ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Doppler Flowmetry ◽  
Cellular Environment ◽  
Microdialysis Study

20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat

2002 ◽  
Vol 282 (4) ◽  
pp. H1556-H1565 ◽  
Author(s):  
Franz Kehl ◽  
Liana Cambj-Sapunar ◽  
Kristopher G. Maier ◽  
Noriyuki Miyata ◽  
Shunishi Kametani ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebrospinal Fluid ◽  
Cerebral Blood Flow ◽  
Subarachnoid Hemorrhage ◽  
Laser Doppler Flowmetry ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Doppler Flowmetry ◽  
Arterial Blood ◽  
Rat Renal Microsomes

This study examined the effects of blocking the formation of 20-hydroxyeicosatetraenoic acid (20-HETE) on the acute fall in cerebral blood flow after subarachnoid hemorrhage (SAH) in the rat. In vehicle-treated rats, regional cerebral blood flow (rCBF) measured with laser-Doppler flowmetry fell by 30% 10 min after the injection of 0.3 ml of arterial blood into the cisterna magna, and it remained at this level for 2 h. Pretreatment with inhibitors of the formation of 20-HETE, 17-octadecynoic acid (17-ODYA; 1.5 nmol intrathecally) and N-hydroxy- N′-(4-butyl-2-methylphenyl)formamidine (HET0016; 10 mg/kg iv), reduced the initial fall in rCBF by 40%, and rCBF fully recovered 1 h after induction of SAH. The concentration of 20-HETE in the cerebrospinal fluid rose from 12 ± 2 to 199 ± 17 ng/ml after SAH in vehicle-treated rats. 20-HETE levels averaged only 15 ± 11 and 39 ± 13 ng/ml in rats pretreated with 17-ODYA or HET0016, respectively. HET0016 selectively inhibited the formation of 20-HETE in rat renal microsomes with an IC50of <15 nM and human recombinant CYP4A11, CYP4F2, and CYP4F3 enzymes with an IC50 of 42, 125, and 100 nM, respectively. These results indicate that 20-HETE contributes to the acute fall in rCBF after SAH in rats.

Assessment of Regional Cerebral Blood Flow and Blood Volume after Aneurysmal Subarachnoid Hemorrhage

2008 ◽  
Vol 18 (4) ◽  
pp. 237-243 ◽  
Author(s):  
Stella Blasel ◽  
Elke Hattingen ◽  
Edgar Dettmann ◽  
Gerald Morawe ◽  
Friedhelm Zanella ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Subarachnoid Hemorrhage ◽  
Blood Volume ◽  
Regional Cerebral Blood Flow ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Regional Cerebral Blood

The Characteristics of Laser-Doppler Flowmetry for the Measurement of Regional Cerebral Blood Flow

Neurosurgery ◽  
1995 ◽  
Vol 36 (2) ◽  
pp. 358???364 ◽  
Author(s):  
Osamu Fukuda ◽  
Shunro Endo ◽  
Naoya Kuwayama ◽  
Jun Harada ◽  
Akira Takaku
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Laser Doppler Flowmetry ◽  
Regional Cerebral Blood Flow ◽  
Laser Doppler ◽  
Regional Cerebral Blood ◽  
Doppler Flowmetry

Regional cerebral blood flow studies in subarachnoid hemorrhage

1972 ◽  
Vol 37 (1) ◽  
pp. 36-44 ◽  
Author(s):  
M. Peter Heilbrun ◽  
Jes Olesen ◽  
Niels A. Lassen
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Subarachnoid Hemorrhage ◽  
Regional Cerebral Blood Flow ◽  
Surgical Intervention ◽  
Focal Ischemia ◽  
Regional Cerebral Blood ◽  
Content Type ◽  
Clinical Grading ◽  
Fine Print

✓ Regional cerebral blood flow (rCBF) studies using the intra-arterial 133xenon method were performed on 10 patients with subarachnoid hemorrhage. Both preoperative and postoperative studies showed evidence of decreased flow in the entire hemisphere studied, and, in addition, evidence of focal ischemia, focal hyperemia, focal vasoparalysis, and often global impairment of autoregulation. The degree of flow abnormalities correlated well with the clinical grading of the neurological deficit. It is suggested that analysis of the state of autoregulation might be useful in determining the time for surgical intervention and that rCBF studies are important in defining the effects of drugs used to counteract the ischemic effects of spasm.

Regional cerebral blood flow in the acute stage of experimentally induced subarachnoid hemorrhage

1983 ◽  
Vol 58 (2) ◽  
pp. 210-216 ◽  
Author(s):  
Felix Umansky ◽  
Thalia Kaspi ◽  
Mordechai N. Shalit
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Subarachnoid Hemorrhage ◽  
Regional Cerebral Blood Flow ◽  
Internal Capsule ◽  
Acute Stage ◽  
Regional Cerebral Blood ◽  
Content Type ◽  
Steep Decline ◽  
Triphasic Pattern

✓ Subarachnoid hemorrhage (SAH) was induced in 13 adult mongrel cats by a slow injection of fresh autogenous blood into the cisterna magna. Serial determinations of regional cerebral blood flow (rCBF) in the cortex and deep-seated areas (internal capsule, thalamus, and caudate nucleus) were made during the following 2 hours, while intracranial pressure (ICP) was maintained at normal values. A decrease in rCBF was observed in all the areas examined. This reduction followed a characteristic triphasic pattern with an initial steep decline immediately after the SAH. The clinical implications of these findings are discussed.

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