scholarly journals Regional distribution of 5α-reductase type 2 in the adult rat brain: An immunohistochemical analysis

2013 ◽  
Vol 38 (2) ◽  
pp. 281-293 ◽  
Author(s):  
M. Paola Castelli ◽  
Alberto Casti ◽  
Angelo Casu ◽  
Roberto Frau ◽  
Marco Bortolato ◽  
...  
2008 ◽  
Vol 60 (4) ◽  
pp. 581-591
Author(s):  
Sanja Dacic ◽  
Sanja Pekovic ◽  
Maja Stojiljkovic ◽  
Irena Lavrnja ◽  
Danijela Stojkov ◽  
...  

The central nervous system has a limited capacity for self-repair after damage. However, the neonatal brain has agreater capacity for recovery than the adult brain. These differences in the regenerative capability depend on local environmental factors and the maturational stage of growing axons. Among molecules which have both growth-promoting and growth-inhibiting activities is the heterogeneous class of chondroitin sulfate proteoglycans (CSPGs). In this paper, we investigated the chondroitin-4 and chondroitin-6 sulfate proteoglycan expression profile after left sensorimotor cortex ablation of the neonatal and adult rat brain. Immunohistochemical analysis revealed that compared to the normal uninjured cortex, lesion provoked up regulation of CSPGs showing a different pattern of expression in the neonatal vs. the adult brain. Punctuate and membrane-bound labeling was predominate after neonatal lesion, where as heavy deposition of staining in the extracellular matrix was observed after adult lesion. Heavy deposition of CSPG immunoreactivity around the lesionsite in adult rats, in contrast to a less CSPG-rich environment in neonatal rats, indicated that enhancement of the recovery process after neonatal injury is due to amore permissive environment.


1981 ◽  
Vol 36 (1) ◽  
pp. 307-309 ◽  
Author(s):  
Timothy S. Brannan ◽  
Howard S. Maker ◽  
Ingrid P. Raes

1980 ◽  
Vol 35 (4) ◽  
pp. 1013-1014 ◽  
Author(s):  
Timothy S. Brannan ◽  
Howard S. Maker ◽  
Cipora Weiss ◽  
Gerald Cohen

Glia ◽  
2002 ◽  
Vol 39 (1) ◽  
pp. 69-84 ◽  
Author(s):  
Lynne A. Holtzclaw ◽  
Siddhesh Pandhit ◽  
Dan J. Bare ◽  
Gregory A. Mignery ◽  
James T. Russell

1998 ◽  
Vol 61 (1-2) ◽  
pp. 1-10 ◽  
Author(s):  
Amanda C. Robson ◽  
Caroline M. Leckie ◽  
Jonathan R. Seckl ◽  
Megan C. Holmes

1985 ◽  
Vol 327 (1-2) ◽  
pp. 153-159 ◽  
Author(s):  
Lisa Simonson ◽  
Michel Baudry ◽  
Robert Siman ◽  
Gary Lynch

1983 ◽  
Vol 42 (3) ◽  
pp. 316
Author(s):  
Martin R. Krigman ◽  
G. Jean Harry ◽  
John M. Canipe ◽  
Paul Mushak

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