Dynamic kinetic resolution of α-chloro β-keto esters and phosphonates: hemisynthesis of Taxotere® through Ru-DIFLUORPHOS asymmetric hydrogenation

2010 ◽  
Vol 21 (11-12) ◽  
pp. 1436-1446 ◽  
Author(s):  
Sébastien Prévost ◽  
Sébastien Gauthier ◽  
Maria Cristina Caño de Andrade ◽  
Céline Mordant ◽  
Ali Rhida Touati ◽  
...  
Keyword(s):  
Kinetic Resolution ◽  
Asymmetric Hydrogenation ◽  
Dynamic Kinetic Resolution ◽  
Keto Esters

Recent Progress and Applications of Transition-Metal-Catalyzed Asymmetric Hydrogenation and Transfer Hydrogenation of Ketones and Imines through Dynamic Kinetic Resolution

Synthesis ◽  
2020 ◽  
Vol 53 (01) ◽  
pp. 30-50
Author(s):  
Phannarath Phansavath ◽  
Virginie Ratovelomanana-Vidal ◽  
Ricardo Molina Betancourt ◽  
Pierre-Georges Echeverria ◽  
Tahar Ayad
Keyword(s):  
Transition Metal ◽  
Asymmetric Catalysis ◽  
Kinetic Resolution ◽  
Asymmetric Hydrogenation ◽  
Short Review ◽  
Transfer Hydrogenation ◽  
Dynamic Kinetic Resolution ◽  
Catalytic Systems ◽  
Keto Esters ◽  
Metal Catalyzed

AbstractBased on the ever-increasing demand for enantiomerically pure compounds, the development of efficient, atom-economical, and sustainable methods to produce chiral alcohols and amines is a major concern. Homogeneous asymmetric catalysis with transition-metal complexes including asymmetric hydrogenation (AH) and transfer hydrogenation (ATH) of ketones and imines through dynamic kinetic resolution (DKR) allowing the construction of up to three stereogenic centers is the main focus of the present short review, emphasizing the development of new catalytic systems combined to new classes of substrates and their applications as well.1 Introduction2 Asymmetric Hydrogenation via Dynamic Kinetic Resolution2.1 α-Substituted Ketones2.2 α-Substituted β-Keto Esters and Amides2.3 α-Substituted Esters2.4 Imine Derivatives3 Asymmetric Transfer Hydrogenation via Dynamic Kinetic Resolution3.1 α-Substituted Ketones3.2 α-Substituted β-Keto Esters, Amides, and Sulfonamides3.3 α,β-Disubstituted Cyclic Ketones3.4 β-Substituted Ketones3.5 Imine Derivatives4. Conclusion

Diastereo- and Enantioselective Asymmetric Hydrogenation of α-Amido-β-keto Phosphonates via Dynamic Kinetic Resolution

2012 ◽  
Vol 15 (1) ◽  
pp. 72-75 ◽  
Author(s):  
Xiaoming Tao ◽  
Wanfang Li ◽  
Xiaoming Li ◽  
Xiaomin Xie ◽  
Zhaoguo Zhang
Keyword(s):  
Kinetic Resolution ◽  
Asymmetric Hydrogenation ◽  
Dynamic Kinetic Resolution
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