Late Relapse of Testicular Germ Cell Tumors

2015 ◽  
Vol 42 (3) ◽  
pp. 359-368 ◽  
Author(s):  
Matthew J. O’Shaughnessy ◽  
Darren R. Feldman ◽  
Brett S. Carver ◽  
Joel Sheinfeld
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Late Relapse ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell

scholarly journals Late and Rapid Relapse in Mediastinum from Testicular Germ Cell Tumor Stage I Over 13 Years after Surgery

2019 ◽  
Vol 12 (2) ◽  
pp. 500-505
Author(s):  
Toshirou Fukushima ◽  
Takuro Noguchi ◽  
Takashi Kobayashi ◽  
Nodoka Sekiguchi ◽  
Takesumi Ozawa ◽  
...  
Keyword(s):  
Germ Cell ◽  
Mediastinal Lymph Node ◽  
Relevant Literature ◽  
Germ Cell Tumors ◽  
Stage I ◽  
Careful Examination ◽  
Late Relapse ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Testicular Seminoma

Patients with stage I testicular germ cell tumors have a long life expectancy, but the tumors have a potential to relapse after treatment. Although relapse is observed within a few years in most cases, late relapse over 10 years after initial treatment has also been reported in patients with stage I testicular germ cell tumors. We encountered a case of testicular seminoma that developed mediastinal lymph node metastasis 13 years after radical surgery for the primary tumor. The relapsed disease progressed rapidly and the patient died within 1 month due to respiratory failure without any chance for therapy. On postmortem examination, the thoracic lesions were pathologically confirmed to be metastases from the testicular seminoma with yolk sac tumor. Here, we report the clinical course and a review of the relevant literature. Based on our experience, we emphasize long-term follow-up and/or careful examination in patients with stage I testicular germ cell tumors.

Late relapse of testicular germ cell tumors

2005 ◽  
Vol 23 (6) ◽  
pp. 441-445 ◽  
Author(s):  
Brett S. Carver ◽  
Robert J. Motzer ◽  
Gnanamba Varuni Kondagunta ◽  
Pramod G. Sogani ◽  
Joel Sheinfeld
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Late Relapse ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell

Active surveillance after orchiectomy for nonseminomatous testicular germ cell tumors: Late relapse may occur

Urology ◽  
1997 ◽  
Vol 50 (4) ◽  
pp. 588-592 ◽  
Author(s):  
Michael J. Boyer ◽  
Keith Cox ◽  
Martin H.N. Tattersall ◽  
Michael P.N. Findlay ◽  
John Grygiel ◽  
...  
Keyword(s):  
Germ Cell ◽  
Active Surveillance ◽  
Germ Cell Tumors ◽  
Late Relapse ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell

969 LATE RELAPSE OF TESTICULAR GERM CELL TUMORS IN 2,729 PATIENTS: A MULTICENTER ANALYSIS

2011 ◽  
Vol 185 (4S) ◽  
Author(s):  
Robert Hoekstra ◽  
Michael Schaapveld ◽  
Alexandra van den Belt-Dusebout ◽  
Ronald de Wit ◽  
Jourik Gietema ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Late Relapse ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Multicenter Analysis

432: Treatment of Late Relapse of Non-Seminomatous Testicular Germ Cell Tumors

2005 ◽  
Vol 173 (4S) ◽  
pp. 118-118
Author(s):  
Markus A. Kuczyk ◽  
Gerhard Wegener ◽  
Axel S. Merseburger ◽  
Stefan A. Machtens ◽  
Udo Jonas ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Late Relapse ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell

Late Relapse in Testicular Germ Cell Tumors

2007 ◽  
Vol 93 (5) ◽  
pp. 428-431
Author(s):  
Beatrice Detti ◽  
Lorenzo Livi ◽  
Silvia Scoccianti ◽  
Icro Meattini ◽  
Mauro Gacci ◽  
...  
Keyword(s):  
Germ Cell ◽  
Combined Treatment ◽  
Germ Cell Tumors ◽  
Late Relapse ◽  
Primary Therapy ◽  
Testicular Germ Cell Tumors ◽  
Retrospective Case ◽  
Testicular Germ Cell ◽  
Small Series

Aims and Background Analysis of patients with late relapse of testicular germ cell tumors (GCTs) with reports on clinicopathological features and outcomes. Methods We identified all patients diagnosed with testicular GCTs at our Institute between 1988 and 2004 who developed relapse ≥24 months after completion of primary therapy. A retrospective case-note review was performed to extract clinical, pathological, treatment and outcome data. Results Six patients (1.25%) developed late relapse. All patients presented with stage I disease and were classified as “good risk” according to the International Germ Cell Consensus Classification. Mean time to late relapse was 48 months. Markers at late relapse were normal in all patients. Relapse was confined to retroperitoneal sites in five patients and located in the mediastinum in one patient. Five patients were managed by chemotherapy alone while one underwent combined treatment with surgery followed by chemotherapy. All patients obtained a complete response and all remained free from recurrence with a mean follow-up of 115 months. Conclusions The incidence of late relapse in this small series is low. Chemonaive patients with late relapse were successfully salvaged with chemotherapy alone or surgical excision followed by cisplatin-based chemotherapy. The optimal duration of follow-up in patients with testicular GCTs is not known and practice varies widely. At our Institute we advise lifelong follow-up of all patients with malignant GCTs of the testis.

Late relapse after treatment for nonseminomatous testicular germ cell tumors according to a single center-based experience

2004 ◽  
Vol 22 (1) ◽  
pp. 55-59 ◽  
Author(s):  
M. A. Kuczyk ◽  
C. Bokemeyer ◽  
C. Kollmannsberger ◽  
S. Corvin ◽  
A. Anastasiadis ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Late Relapse ◽  
Testicular Germ Cell Tumors ◽  
Single Center ◽  
Testicular Germ Cell

Serum Lactate Dehydrogenase Isoenzyme 1 and Relapse in Patients with Nonseminomatous Testicular Germ Cell Tumors Clinical Stage I

2001 ◽  
Vol 40 (4) ◽  
pp. 536-540 ◽  
Author(s):  
Finn Edler von Eyben ◽  
Ebbe Lindegaard Madsen ◽  
Ole Blaabjerg ◽  
Per Hyltoft Petersen ◽  
Hans von der Maase ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Germ Cell ◽  
Clinical Stage ◽  
Germ Cell Tumors ◽  
Serum Lactate ◽  
Stage I ◽  
Serum Lactate Dehydrogenase ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Dehydrogenase Isoenzyme
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