Plasma renin activity revealed renal artery stenosis concealed by aneurysms

Urology ◽  
2005 ◽  
Vol 65 (3) ◽  
pp. 592
Author(s):  
Masayuki Tanemoto ◽  
Takaaki Abe ◽  
Fumitoshi Satoh ◽  
Sadayoshi Ito
Heart ◽  
2013 ◽  
Vol 99 (Suppl 1) ◽  
pp. A62.3-A62
Author(s):  
Li Hua ◽  
Jia Nan ◽  
Zhu Li Min ◽  
Tang Xiao Feng ◽  
Gao Pingjin

1989 ◽  
Vol 7 ◽  
pp. S186-187 ◽  
Author(s):  
Alberto Morganti ◽  
Patrizia Quorso ◽  
Paola Ferraris ◽  
Andrea Lovaria ◽  
Maria Fruscio ◽  
...  

1975 ◽  
Vol 16 (6) ◽  
pp. 741-748 ◽  
Author(s):  
Miyuki ISHIBASHI ◽  
Akiteru TAKEUCHI ◽  
Shinji YOKOYAMA ◽  
Tohru YAMAJI ◽  
Tsuneto TSUCHIMOCHI ◽  
...  

2001 ◽  
Vol 280 (1) ◽  
pp. F119-F125 ◽  
Author(s):  
Bianca Mann ◽  
Andrea Hartner ◽  
Boye L. Jensen ◽  
Karl F. Hilgers ◽  
Klaus Höcherl ◽  
...  

This study aimed to characterize the influence of acute renal artery stenosis on cyclooxygenase-2 (COX-2) and renin expression in the juxtaglomerular apparatus. For this purpose, male Sprague-Dawley rats received a left renal artery clip, and COX-2 mRNA, COX-2 immunoreactivity, plasma renin activity, and renin mRNA levels were determined. COX-2 mRNA and COX-2 immunoreactivity in the macula densa region in the clipped kidneys increased as early as 6 h after clipping and reached a maximal expression 1–2 days after clipping. Although values for plasma renin activity were elevated markedly at all time points examined, remaining renin mRNA levels were unchanged after 6 h and then increased to reach a maximum value 1–2 days after clipping. In the contralateral intact kidney, renin mRNA and COX-2 immunoreactivity decreased to ∼50% of their normal values. To investigate a possible causal relationship between the changes of COX-2 and of renin expression, clipped rats were treated with the COX-2 blocker celecoxib (40 mg · kg−1 · day−1). This treatment, however, did not change renin mRNA either in the clipped or in the contralateral intact kidney. Our findings indicate that renal artery stenosis causes ipsilaterally an acute upregulation and contralaterally a downregulation of juxtaglomerular COX-2 expression. The lacking effect of celecoxib on renin gene expression does not support the concept of a direct mediator function of COX-2-derived prostaglandins in the control of renin expression during renal hypoperfusion.


1974 ◽  
Vol 48 (s2) ◽  
pp. 69s-71s
Author(s):  
G. G. Geyskes ◽  
P. Boer ◽  
F. H. H. Leenen ◽  
E. J. Dorhout Mees

1. In nineteen patients, five with unilateral renal artery stenosis and fourteen with essential hypertension (WHO grades I–II), blood pressure, plasma and extracellular fluid volumes and plasma renin activity were studied at the end of three sequential periods: (a) after at least 3 days on a 60 mmol Na+ diet; (b) after 3 days of salt depletion induced with a diuretic and sustained on a 20 mmol Na+ diet; (c) after 3 days during which the 20 mmol Na+ diet was continued and beta-receptor blockade was induced by increasing dosages of propranolol up to 320 mg daily. 2. After sodium depletion extracellular fluid volume and plasma volume decreased and plasma renin activity increased; blood pressure did not change significantly. 3. After adding propranolol, plasma volume and extracellular fluid volume remained low, and there was a significant decrease in plasma renin activity and blood pressure. 4. No correlation could be demonstrated between changes of blood pressure and plasma renin activity. 5. When the responses of the five patients with renal artery stenosis were compared with those of the fourteen patients with essential hypertension, no significant differences were found. 6. Propranolol has a strong anti-hypertensive effect after Na+ depletion, irrespective of the absolute activities of plasma renin.


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