Safety and immunogenicity of a recombinant hepatitis B vaccine manufactured by a modified process in renal pre-dialysis and dialysis patients

Vaccine ◽  
2014 ◽  
Vol 32 (48) ◽  
pp. 6521-6526 ◽  
Author(s):  
Christopher L. Gilbert ◽  
Jon E. Stek ◽  
Giuseppe Villa ◽  
Stephanie O. Klopfer ◽  
Jason C. Martin ◽  
...  
1996 ◽  
Vol 16 (4) ◽  
pp. 370-373 ◽  
Author(s):  
Abdul N. Khan ◽  
Judy Bernardini ◽  
Raymond M. Rault ◽  
Beth Piraino

Objective To compare seroconversion using hepatitis B vaccine between hemodialysis (HD) and peritoneal dialysis (PD) patients. Design Data on PD patients vaccinated were collected retrospectively for the period 1992 to 1995. The data on HD patients were collected prospectively from 1991 to 1994. Setting A university outpatient dialysis center. Participants All adult patients who received all four doses of hepatitis B vaccine while on dialysis were included (47 PD and 50 HD patients). Intervention Recombinant hepatitis B vaccine (Engerix), 40 μg IM was administered at 0, 1, 2, and 6 months. Main Outcome Measure Seroconversion was measured after completion of the vaccination series. Results 74% of the HD patients seroconverted compared to 53 % of PD patients (p = 0.03). Older, heavier patients compared to all the other patients had a lower seroconversion rate in both the HD patients (55 % vs. 78 %) and PD patients (38 % vs. 59 %) (p = 0.03). Conclusion The seroconversion rate to recombinant hepatitis B vaccine is lower in patients on PD than on HD for unclear reasons. Further studies are required to determine the etiology of this difference.


1991 ◽  
Vol 22 (3) ◽  
pp. 251-257 ◽  
Author(s):  
S.J. Fleming ◽  
D.M. Moran ◽  
W.G.E. Cooksley ◽  
J.L. Faoagali

2015 ◽  
Vol 40 (6) ◽  
pp. 584-592 ◽  
Author(s):  
Fabrizio Fabrizi ◽  
Antonio Tarantino ◽  
Claudia Castelnovo ◽  
Paul Martin ◽  
PierGiorgio Messa

1986 ◽  
Vol 3 (2) ◽  
pp. 190-195 ◽  
Author(s):  
W. Jilg ◽  
M. Schmidt ◽  
B. Weinel ◽  
Th. Küttler ◽  
H. Brass ◽  
...  

1994 ◽  
Vol 9 (8) ◽  
pp. 1213-1214 ◽  
Author(s):  
J. M. Poux ◽  
S. Ranger ◽  
C. Lagarde ◽  
D. Benevent ◽  
F. Denis ◽  
...  

Infection ◽  
1989 ◽  
Vol 17 (2) ◽  
pp. 70-76 ◽  
Author(s):  
W. Jilg ◽  
Marion Schmidt ◽  
F. Deinhardt

1988 ◽  
Vol 29 (4) ◽  
pp. 211-214 ◽  
Author(s):  
P. M. Mannucci ◽  
A. Gringeri ◽  
M. Morfini ◽  
R. De Biasi ◽  
M. C. Tirindelli ◽  
...  

1989 ◽  
Vol 33 (2) ◽  
pp. 113
Author(s):  
J. Y. WEISSMAN ◽  
M. M. TSUCHIYOSE ◽  
M. J. TONG ◽  
R. CO ◽  
K. CHIN ◽  
...  

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