Effect of subchronic lithium carbonate treatment on anxiolytic-like effect of citalopram and MKC-242 in conditioned fear stress in the rat

1999 ◽  
Vol 383 (3) ◽  
pp. 223-229 ◽  
Author(s):  
Ihoko Muraki ◽  
Takeshi Inoue ◽  
Shinji Hashimoto ◽  
Takeshi Izumi ◽  
Koichi Ito ◽  
...  
Keyword(s):  
Conditioned Fear ◽  
Lithium Carbonate ◽  
Conditioned Fear Stress ◽  
Lithium Carbonate Treatment

Lithium Carbonate Treatment of Alcoholism

1987 ◽  
Author(s):  
J. Fawcett ◽  
◽  
D. C. Clark ◽  
C. A. Aagesen ◽  
V. D. Pisani ◽  
...  
Keyword(s):  
Lithium Carbonate ◽  
Lithium Carbonate Treatment

scholarly journals Effect of OPC-14523 on conditioned fear stress in mice

1998 ◽  
Vol 76 ◽  
pp. 195
Author(s):  
Sakiko Yamada ◽  
Katsura Tottori ◽  
Yasufumi Uwahodo ◽  
Takashi Miwa ◽  
Yasuo Oshiro ◽  
...  
Keyword(s):  
Conditioned Fear ◽  
Conditioned Fear Stress

Asenapine reduces anxiety-related behaviours in rat conditioned fear stress model

2016 ◽  
Vol 28 (6) ◽  
pp. 327-336 ◽  
Author(s):  
Masayo Ohyama ◽  
Maho Kondo ◽  
Miki Yamauchi ◽  
Taiichiro Imanishi ◽  
Tsukasa Koyama
Keyword(s):  
Receptor Antagonist ◽  
Partial Agonist ◽  
Conditioned Fear ◽  
Serotonin Release ◽  
Rat Hippocampus ◽  
Stress Model ◽  
Electrical Shock ◽  
Conditioned Fear Stress ◽  
Skinner Box

ObjectiveAsenapine is an atypical antipsychotic that is currently available for the treatment of schizophrenia and bipolar I disorder. Although the atypical antipsychotics clozapine and olanzapine are effective for depression and anxiety in schizophrenia, as demonstrated by animal model studies, this has not been clarified for asenapine. Therefore, we compared the effects of asenapine in the conditioned fear stress model with those of clozapine and olanzapine.MethodRats were individually fear conditioned using electrical foot shock in a Skinner box. Approximately 24 h later, individual animals were returned to the same Skinner box (without electrical shock) and their freezing behaviour was observed for 5 min. Animals were treated with asenapine, clozapine, olanzapine, the 5-HT1A receptor partial agonist buspirone, or the 5-HT2C receptor antagonist SB242084 at 30 min before freezing behaviour assessment. The 5-HT1A receptor antagonist WAY100635 or the 5-HT2C receptor agonist Ro60-0175 was also used concomitantly with asenapine. The effects of asenapine, clozapine, and olanzapine on serotonin release in the rat hippocampus were also measured using in vivo microdialysis.ResultsAsenapine reduced freezing behaviour, while neither clozapine nor olanzapine reduced freezing behaviour. Buspirone and SB242084 also reduced freezing behaviour. The effect of asenapine in reducing freezing behaviour was not altered by the concomitant administration of WAY100635 or Ro60-0175. Both asenapine and clozapine, but not olanzapine, increased serotonin release in the rat hippocampus.ConclusionAsenapine may have superior therapeutic effect on anxiety symptoms than other agents, although the underlying mechanism of its anxiolytic activity remains unknown.

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