scholarly journals Effect of 5-phosphoribosyl-a-pyrophosphate on de novo pyrimidine biosynthesis in cultured Ehrlich ascites cells made permeable with dextran sulfate 500.

1979 ◽  
Vol 254 (8) ◽  
pp. 2697-2704
Author(s):  
J.J. Chen ◽  
M.E. Jones
Keyword(s):  
Dextran Sulfate ◽  
De Novo ◽  
Pyrimidine Biosynthesis ◽  
Ehrlich Ascites ◽  
Ehrlich Ascites Cells

Utilization of ammonium ions for purine precursor synthesis in soluble extracts of Ehrlich ascites cells

1969 ◽  
Vol 47 (9) ◽  
pp. 839-845 ◽  
Author(s):  
D. Trachewsky ◽  
R. M. Johnstone
Keyword(s):  
De Novo ◽  
Ammonium Ion ◽  
Ammonium Ions ◽  
Purine Analogues ◽  
Experimental Conditions ◽  
Purine Synthesis ◽  
Ehrlich Ascites ◽  
Precursor Synthesis ◽  
Ehrlich Ascites Cells

In extracts of Ehrlich ascites cells the synthesis of α-N-formylglycinamide ribonucleotide (FGAR), an early intermediate in de novo purine synthesis, is enhanced by the presence of ammonium ions. Under these experimental conditions glutamine participation in FGAR formation is not obligatory. Ribonucleotides, deoxyribonucleotides, and purine analogues which inhibit glutamine-dependent FGAR synthesis also inhibit ammonium-ion-dependent FGAR synthesis. 3′-Ribonucleotides do not inhibit purine precursor formation from ammonium ions or from glutamine.

Metabolism and non-random occurrence of nonnascent short chains in the DNA of Ehrlich ascites cells

1983 ◽  
Vol 740 (2) ◽  
pp. 200-211 ◽  
Author(s):  
Hans Probst ◽  
Thomas Hofstaetter ◽  
Hans-Stephan Jenke ◽  
Peter R. Gentner ◽  
Dagmar Müller-Scholz
Keyword(s):  
Random Occurrence ◽  
Ehrlich Ascites ◽  
Ehrlich Ascites Cells
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