scholarly journals Covalent interaction of L-2-amino-4-oxo-5-chloropentanoic acid with rat renal phosphate-dependent glutaminase. Evidence for a specific glutamate binding site and of subunit heterogeneity.

1978 ◽  
Vol 253 (19) ◽  
pp. 7086-7090
Author(s):  
R.A. Shapiro ◽  
V.M. Clark ◽  
N.P. Curthoys
Keyword(s):  
Binding Site ◽  
Covalent Interaction ◽  
Glutamate Binding

Synthesis and tubulin interaction of thiocolchicines containing an isothiocyanato group. Synthesis of C(2)-deuterated and C(2)-14C-labeled 7-isothiocyanatodeacetamidothiocolchicine

1991 ◽  
Vol 56 (11) ◽  
pp. 2306-2312 ◽  
Author(s):  
Anjum Muzaffar ◽  
Ernest Hamel ◽  
Rouli Bai ◽  
Arnold Brossi
Keyword(s):  
Binding Site ◽  
Covalent Bond ◽  
Tubulin Polymerization ◽  
Low Concentration ◽  
Covalent Interaction ◽  
Isotope Label ◽  
Colchicine Binding Site

Synthesis of isothiocyanato substituted thiocolchicines XI - XIV is described. Introduction of an isotope label is demonstrated with the deuterated isothiocyanate XII and the 14C-labeled analog XIII. These isothiocyanates inhibit tubulin polymerization at low concentration. In addition, the 14C-labeled XIII forms covalent bond(s) with tubulin. Unfortunately, the covalent reaction while rapid, is not inhibited by preincubation of tubulin with colchicine. The covalent interaction of XIII with tubulin thus appears to be nonspecific, limiting its use as a marker of the colchicine binding site on tubulin.

scholarly journals Modification of the Glutamate Binding Site of the NMDA Receptor During Graded Hypoxia in the Cerebral Cortex of Newborn Piglets. † 183

1997 ◽  
Vol 41 ◽  
pp. 33-33
Author(s):  
Karen I. Fritz ◽  
Joanna Kubin ◽  
Eric Lombardini ◽  
Om P. Mishra ◽  
Maria Delivoria-Papadopoulos
Keyword(s):  
Cerebral Cortex ◽  
Nmda Receptor ◽  
Binding Site ◽  
Newborn Piglets ◽  
Glutamate Binding

scholarly journals Structural Determinants of Agonist Efficacy at the Glutamate Binding Site ofN-Methyl-d-Aspartate Receptors

2013 ◽  
Vol 84 (1) ◽  
pp. 114-127 ◽  
Author(s):  
Kasper B. Hansen ◽  
Nami Tajima ◽  
Rune Risgaard ◽  
Riley E. Perszyk ◽  
Lars Jørgensen ◽  
...  
Keyword(s):  
Binding Site ◽  
Structural Determinants ◽  
Glutamate Binding

A Novel Chloride-Dependent L-[3H]Glutamate Binding Site in Astrocyte Membranes

1987 ◽  
Vol 48 (6) ◽  
pp. 1709-1715 ◽  
Author(s):  
Richard J. Bridges ◽  
Manuel Nieto-Sampedro ◽  
Munaf Kadri ◽  
Carl W. Cotman
Keyword(s):  
Binding Site ◽  
Glutamate Binding

Structural Basis for Understanding Structure−Activity Relationships for the Glutamate Binding Site of the NMDA Receptor

2002 ◽  
Vol 45 (18) ◽  
pp. 3836-3843 ◽  
Author(s):  
Irina G. Tikhonova ◽  
Igor I. Baskin ◽  
Vladimir A. Palyulin ◽  
Nikolai S. Zefirov ◽  
Sergey O. Bachurin
Keyword(s):  
Nmda Receptor ◽  
Binding Site ◽  
Structural Basis ◽  
Structure Activity Relationships ◽  
Glutamate Binding ◽  
Structure Activity

205 Analysis of the glutamate binding site on the NR2B subunit of NMDA receptor

1997 ◽  
Vol 28 ◽  
pp. S31
Author(s):  
Hirokazu Hirai ◽  
Bodo Laube ◽  
Jochen Kuhse ◽  
Heinrich Betz
Keyword(s):  
Nmda Receptor ◽  
Binding Site ◽  
Nr2b Subunit ◽  
Glutamate Binding

scholarly journals Development of Radiolabeled Ligands Targeting the Glutamate Binding Site of theN-Methyl-d-aspartate Receptor as Potential Imaging Agents for Brain

2016 ◽  
Vol 59 (24) ◽  
pp. 11110-11119 ◽  
Author(s):  
Lucia Tamborini ◽  
Ying Chen ◽  
Catherine A. Foss ◽  
Andrea Pinto ◽  
Andrew G. Horti ◽  
...  
Keyword(s):  
Binding Site ◽  
Imaging Agents ◽  
Glutamate Binding ◽  
Aspartate Receptor

scholarly journals Structural Basis for Understanding Structure−Activity Relationships for the Glutamate Binding Site of the NMDA Receptor.

2002 ◽  
Vol 45 (25) ◽  
pp. 5608-5608 ◽  
Author(s):  
Irina G. Tikhonova ◽  
Igor I. Baskin ◽  
Vladimir A. Palyulin ◽  
Nikolai S. Zefirov ◽  
Sergey O. Bachurin
Keyword(s):  
Nmda Receptor ◽  
Binding Site ◽  
Structural Basis ◽  
Structure Activity Relationships ◽  
Glutamate Binding ◽  
Structure Activity

A l-[3H]glutamate binding site on glia: an autoradiographic study on implanted astrocytes

1987 ◽  
Vol 415 (1) ◽  
pp. 163-168 ◽  
Author(s):  
Richard J. Bridges ◽  
J. Patrick Kesslak ◽  
Manuel Nieto-Sampedro ◽  
Joseph T. Broderick ◽  
Jen Yu ◽  
...  
Keyword(s):  
Binding Site ◽  
Autoradiographic Study ◽  
Glutamate Binding
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