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2022 ◽  
Vol 228 ◽  
pp. 107159
Chen Song ◽  
Fang Liu ◽  
Weiliao Kang ◽  
Jiangyuan Zhao ◽  
Li Yang ◽  

EcoMat ◽  
2022 ◽  
Guoshen Yang ◽  
Jialei Huang ◽  
Xuhao Wan ◽  
Binbin Liu ◽  
Yachao Zhu ◽  
Zinc Ion ◽  

Yanwen Zhang ◽  
Jiaqi Che ◽  
Changlu Yu ◽  
Hanxiang Wang ◽  
Mingchao Du

At present, buckling pin in the bypass of piping as pressure relief valve has been gradually utilized in the low-concentration coal-bed methane (CBM), which bends to release pressure when the main valve fails leading to pipeline blockage. However, current researches mainly focused on the buckling behavior of hydraulic cylinder rod or rod string, and less consideration was given to the operational reliability of buckling pin valves. This paper deduced the calculation formula of the critical failure load based on Euler formula in the buckling pin under buckling load. Besides, three finite element models (FEM) based on Johnson−Cook constitutive model were compared to predict failure strength of buckling pin which were verified by experiment. In addition, the defect sensitivity analysis of the buckling pin under different initial geometric defects rate was carried out. The results showed that a) the experimental value of the critical failure load in the buckling pin was 206.04 N and the bending position was in the middle of the buckling pin; b) the analysis result adopting explicit dynamic method was in best agreement with the experimental results within deviation of 0.24%; and c) the initial geometric defect of buckling pin should be controlled within 1%. This study provides an important reference to predict the critical failure load of the buckling pin valve and achieve safe transportation of low-concentration CBM.

2022 ◽  
Vol 12 ◽  
Fatiha Sebih ◽  
Nawfel Mokrane ◽  
Pierre Fontanel ◽  
Mete Kayatekin ◽  
Mahira Kaabeche ◽  

Gamma-L-glutamyl-L-glutamate (γ-Glu-Glu) was synthetized and further characterized for its activity on cultured neurons. We observed that γ-Glu-Glu elicited excitatory effects on neurons likely by activating mainly the N-methyl-D-aspartate (NMDA) receptors. These effects were dependent on the integrity of synaptic transmission as they were blocked by tetrodotoxin (TTX). We next evaluated its activity on NMDA receptors by testing it on cells expressing these receptors. We observed that γ-Glu-Glu partially activated NMDA receptors and exhibited better efficacy for NMDA receptors containing the GluN2B subunit. Moreover, at low concentration, γ-Glu-Glu potentiated the responses of glutamate on NMDA receptors. Finally, the endogenous production of γ-Glu-Glu was measured by LC-MS on the extracellular medium of C6 rat astroglioma cells. We found that extracellular γ-Glu-Glu concentration was, to some extent, directly linked to GSH metabolism as γ-Glu-Glu can be a by-product of glutathione (GSH) breakdown after γ-glutamyl transferase action. Therefore, γ-Glu-Glu could exert excitatory effects by activating neuronal NMDA receptors when GSH production is enhanced.

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