Conformationally constrained analogues of diacylglycerol (DAG). Part 19: Asymmetric syntheses of (3R)- and (3S)-3-hydroxy-4,4-disubstituted heptono-1,4-lactones as protein kinase C (PK-C) ligands with increased hydrophilicity

Tetrahedron ◽  
2002 ◽  
Vol 58 (26) ◽  
pp. 5335-5345 ◽  
Author(s):  
Kassoum Nacro ◽  
Jeewoo Lee ◽  
Joseph J Barchi ◽  
Nancy E Lewin ◽  
Peter M Blumberg ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Asymmetric Syntheses ◽  
Conformationally Constrained ◽  
Kinase C

Conformationally constrained analogs of diacylglycerol. Interaction of .gamma.-lactones with the phorbol ester receptor of protein kinase C

1992 ◽  
Vol 114 (3) ◽  
pp. 1059-1070 ◽  
Author(s):  
Kelly Teng ◽  
Victor E. Marquez ◽  
George W. A. Milne ◽  
Joseph J. Barchi ◽  
Marcelo G. Kazanietz ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Phorbol Ester ◽  
Conformationally Constrained ◽  
Kinase C ◽  
Phorbol Ester Receptor

Macrocyclic Diacylglycerol-bis-lactones as Conformationally Constrained Analogues of Diacylglycerol-lactones. Interactions with Protein Kinase C

2004 ◽  
Vol 47 (16) ◽  
pp. 4000-4007 ◽  
Author(s):  
Ji-Hye Kang ◽  
Su Yeon Kim ◽  
Jeewoo Lee ◽  
Victor E. Marquez ◽  
Nancy E. Lewin ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Conformationally Constrained ◽  
Kinase C

Conformationally Constrained Analogues of Diacylglycerol. 11.1Ultrapotent Protein Kinase C Ligands Based on a Chiral 5-Disubstituted Tetrahydro-2-furanone Template

1996 ◽  
Vol 39 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Jeewoo Lee ◽  
Shaomeng Wang ◽  
George W. A. Milne ◽  
Rajiv Sharma ◽  
Nancy E. Lewin ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Conformationally Constrained ◽  
Kinase C
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