Imidazole as leaving group in aromatic nucleophilic substitution reactions

1982 ◽  
Vol 23 (43) ◽  
pp. 4423-4426 ◽  
Author(s):  
Elba B. de Vargas ◽  
Rita H. de Rossi
Keyword(s):  
Nucleophilic Substitution ◽  
Substitution Reactions ◽  
Aromatic Nucleophilic Substitution ◽  
Nucleophilic Substitution Reactions ◽  
Leaving Group

ChemInform Abstract: Aromatic Nucleophilic Substitution Reactions of Activated N- Arylpyrazoles with Formamides.

ChemInform ◽  
2010 ◽  
Vol 27 (21) ◽  
pp. no-no
Author(s):  
C. I. CHIRIAC ◽  
V. LUPU ◽  
F. CHIRIAC ◽  
R. ROPOT ◽  
M. TIBIRNA ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Substitution Reactions ◽  
Aromatic Nucleophilic Substitution ◽  
Nucleophilic Substitution Reactions

scholarly journals Leaving Group Ability in Nucleophilic Aromatic Amination by Sodium Hydride–Lithium Iodide Composite

Synthesis ◽  
2019 ◽  
Vol 52 (03) ◽  
pp. 393-398
Author(s):  
Jia Hao Pang ◽  
Derek Yiren Ong ◽  
Kohei Watanabe ◽  
Ryo Takita ◽  
Shunsuke Chiba
Keyword(s):  
Nucleophilic Substitution ◽  
Methoxy Group ◽  
Sodium Hydride ◽  
Lithium Iodide ◽  
Substitution Reactions ◽  
Computational Approaches ◽  
Nucleophilic Substitution Reactions ◽  
Leaving Group ◽  
Leaving Group Ability

The methoxy group is generally considered as a poor leaving group for nucleophilic substitution reactions. This work verified the superior ability of the methoxy group in nucleophilic amination of arenes mediated by the sodium hydride and lithium iodide through experimental and computational approaches.

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