scholarly journals Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

Structure ◽  
1999 ◽  
Vol 7 (1) ◽  
pp. 81-89 ◽  
Author(s):  
Charles S Bond ◽  
Yihong Zhang ◽  
Matthew Berriman ◽  
Mark L Cunningham ◽  
Alan H Fairlamb ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Trypanosoma Cruzi ◽  
Natural Product ◽  
Trypanothione Reductase

scholarly journals The crystal structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 Å resolution

1996 ◽  
Vol 5 (1) ◽  
pp. 52-61 ◽  
Author(s):  
Yihong Zhang ◽  
Charles S. Bond ◽  
Susan Bailey ◽  
Mark L. Cunningham ◽  
Alan H. Fairlamb ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Trypanosoma Cruzi ◽  
Trypanothione Reductase ◽  
Human Pathogen

Crystal structure of Q4D6Q6, a conserved kinetoplastid-specific protein from Trypanosoma cruzi

2020 ◽  
Vol 211 (2) ◽  
pp. 107536
Author(s):  
Éverton Dias D'Andréa ◽  
Yvette Roske ◽  
Guilherme A.P. de Oliveira ◽  
Nils Cremer ◽  
Anne Diehl ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Trypanosoma Cruzi ◽  
Specific Protein

ChemInform Abstract: Structure-Activity Relationships in 2-Aminodiphenylsulfides Against Trypanothione Reductase from Trypanosoma cruzi.

ChemInform ◽  
2010 ◽  
Vol 29 (38) ◽  
pp. no-no
Author(s):  
S. GIRAULT ◽  
E. DAVIOUD-CHARVET ◽  
L. SALMON ◽  
A. BERECIBAR ◽  
M.-A. DEBREU ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Trypanothione Reductase ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Abstract Structure

Synthesis of the Troponoid Natural Product Nezukone Via Sequential Rearrangement of Two Isomeric Precursors

1993 ◽  
Vol 46 (12) ◽  
pp. 1941 ◽  
Author(s):  
MG Banwell ◽  
CJ Cowden ◽  
GL Gravatt ◽  
CEF Rickard
Keyword(s):  
Crystal Structure ◽  
Natural Product ◽  
X Ray ◽  
Key Features

Nezukone (1) has been synthesized in seven steps from the readily available Δ3-trinorcarene (4). Key features of the sequence used include formation of the bicyclic isomer (2) of compound (1). Base-promoted isomerization of compound (2) followed by acidic workup then produced the isolable but highly unstable heptafulvenol (3), an extended enolic tautomer of nezukone (1). Under mildly basic conditions compound (3) rearranged to give the natural product (1). The X-ray crystal structure of the ring-fused cyclobutanone (8) is reported.

4-Methyl-3H-pyrrolo[2,3-c]quinoline

2006 ◽  
Vol 62 (7) ◽  
pp. o2728-o2730 ◽  
Author(s):  
Akkharawit Kanjana-opas ◽  
Somrak Panphon ◽  
Hoong-Kun Fun ◽  
Suchada Chantrapromma
Keyword(s):  
Crystal Structure ◽  
Natural Product ◽  
Dihedral Angle ◽  
Title Compound ◽  
Marine Natural Product ◽  
Asymmetric Unit ◽  
Compound C ◽  
Gliding Bacterium ◽  
First Time ◽  
Hydrogen Bonded

The title compound, C12H10N2, is a new marine natural product which was isolated for the first time from a novel marine gliding bacterium. The asymmetric unit contains a pair of achiral molecules. Both the molecules are essentially planar and they form a dihedral angle of 83.81 (3)°. In the crystal structure, the molecules exist as N—H...N hydrogen-bonded tetramers.

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