Pain: morphine, metabolites, mambas, and mutations

2013 ◽  
Vol 12 (1) ◽  
pp. 18-20 ◽  
Author(s):  
Clifford J Woolf
Keyword(s):  
Morphine Metabolites

Morphine metabolites

1997 ◽  
Vol 41 (1) ◽  
pp. 116-122 ◽  
Author(s):  
L. L. CHRISTRUP
Keyword(s):  
Morphine Metabolites

Concentrations of morphine, morphine metabolites and peptides in human CSF and plasma

Pain ◽  
1990 ◽  
Vol 41 ◽  
pp. S188 ◽  
Author(s):  
R.F. Venn ◽  
A. Michalkieaicz ◽  
P. Hardy ◽  
C. Wells
Keyword(s):  
Morphine Metabolites

scholarly journals Sensitive and Specific Morphine Radioimmunoassay with Iodine Label: Pharmacokinetics of Morphine in Man after Intravenous Administration

1984 ◽  
Vol 21 (4) ◽  
pp. 318-325 ◽  
Author(s):  
R A Moore ◽  
D Baldwin ◽  
M C Allen ◽  
P J Q Watson ◽  
R E S Bullingham ◽  
...  
Keyword(s):  
Intravenous Administration ◽  
Drugs Of Abuse ◽  
Cross Reactivity ◽  
Pharmacokinetic Parameters ◽  
Published Data ◽  
Morphine Metabolites

Analysis of morphine in plasma by radioimmunoassay is complicated by interference from morphine metabolites, particularly morphine-3-glucuronide. This interference makes radioimmunoassay a poor technique to study the pharmacokinetics of morphine in man. The method described here is one which uses commercially available anti-morphine antiserum and separating reagent with a simply prepared iodinated morphine derivative. Cross-reactivity to morphine metabolites is negligible and the method correlates well with HPLC. Results obtained for pharmacokinetic parameters after intravenous administration in man are in agreement with published data using GLC or HPLC. The method is inexpensive, simple and rapid; choice of a different antiserum could allow the method to be used for screening for drugs of abuse such as morphine, diamorphine, codeine and dihydrocodeine.

Potential analgesic contribution from morphine metabolites following intra-thecal morphine

1992 ◽  
Vol 6 (1) ◽  
pp. 38
Author(s):  
P.D. McDonagh ◽  
J. Billett ◽  
W.P. Blunnie ◽  
N. Murphy
Keyword(s):  
Morphine Metabolites

scholarly journals Distinct pharmacological properties of morphine metabolites at Gi-protein and β-arrestin signaling pathways activated by the human μ-opioid receptor

2011 ◽  
Vol 81 (10) ◽  
pp. 1248-1254 ◽  
Author(s):  
Nadine Frölich ◽  
Christian Dees ◽  
Christian Paetz ◽  
Xuan Ren ◽  
Martin J. Lohse ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Opioid Receptor ◽  
Pharmacological Properties ◽  
Gi Protein ◽  
Μ Opioid Receptor ◽  
Morphine Metabolites
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