98% Enantioselectivity in the asymmetric synthesis of a useful chiral building block by heterogeneous method: Enantioselective hydrogenation of ethyl-benzoylformate over cinchona modified Pt/Al2O3 catalysts in the acetic acid

2002 ◽  
Vol 3 (3) ◽  
pp. 125-127 ◽  
Author(s):  
Mária Sutyinszki ◽  
Kornél Szöri ◽  
Károly Felföldi ◽  
Mihály Bartók
Keyword(s):  
Acetic Acid ◽  
Asymmetric Synthesis ◽  
Building Block ◽  
Enantioselective Hydrogenation ◽  
Chiral Building Block ◽  
Ethyl Benzoylformate

Asymmetric synthesis of (−)- and (+)-kainic acid using a planar chiral amide as a chiral building block

2008 ◽  
Vol 49 (44) ◽  
pp. 6327-6329 ◽  
Author(s):  
Katsuhiko Tomooka ◽  
Toshiyuki Akiyama ◽  
Phewluangdee Man ◽  
Masaki Suzuki
Keyword(s):  
Asymmetric Synthesis ◽  
Kainic Acid ◽  
Building Block ◽  
Chiral Building Block

Article

1998 ◽  
Vol 76 (9) ◽  
pp. 1304-1307
Author(s):  
Yoshifumi Yuasa ◽  
Yoko Yuasa ◽  
Haruki Tsuruta
Keyword(s):  
Building Block ◽  
Enantioselective Hydrogenation ◽  
Renin Inhibitor ◽  
Renin Inhibitors ◽  
Propenoic Acid ◽  
Chiral Building Block

(2S)-3-(tert-Butylsulfonyl)-2-benzylpropionic acid 1, which is used as the N-terminal chiral building block of renin inhibitors, is synthesized from (Z)-2-(tert-butylsulfonylmethyl)-3-phenyl-2-propenoic acid 6 by enantioselective hydrogenation using Ru-BINAP complexes in the presence of triethylamine with 84% ee. The enantioselective hydrogenation of a substrate with sulfone functionality is first reported.Key words: hydrogenation, enantioselectivity, Ru-BINAP, oxidation, renin inhibitor.

trans-6-Aminocyclohept-3-enols, a New Designed Polyfunctionalized Chiral Building Block for the Asymmetric Synthesis of 2-Substituted-4-hydroxypiperidines

2002 ◽  
Vol 4 (8) ◽  
pp. 1367-1370 ◽  
Author(s):  
Paolo Celestini ◽  
Bruno Danieli ◽  
Giordano Lesma ◽  
Alessandro Sacchetti ◽  
Alessandra Silvani ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Building Block ◽  
Chiral Building Block
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