indole alkaloids
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2022 ◽  
Vol 194 ◽  
pp. 113017
Author(s):  
Rudolf Vrabec ◽  
Jana Maříková ◽  
Miroslav Ločárek ◽  
Jan Korábečný ◽  
Daniela Hulcová ◽  
...  

Marine Drugs ◽  
2022 ◽  
Vol 20 (1) ◽  
pp. 67
Author(s):  
Elin Julianti ◽  
Ikram Ammar Abrian ◽  
Marlia Singgih Wibowo ◽  
Muhammad Azhari ◽  
Nadya Tsurayya ◽  
...  

Colorectal cancer is one of the most common cancers diagnosed in the world. Chemotheraphy is one of the most common methods used for the pharmacological treatment of this cancer patients. Nevertheless, the adverse effect of chemotherapy is not optimized for improving the quality of life of people who are older, who are the most vulnerable subpopulation. This review presents recent updates regarding secondary metabolites derived from marine fungi and actinobacteria as novel alternatives for cytotoxic agents against colorectal cancer cell lines HCT116, HT29, HCT15, RKO, Caco-2, and SW480. The observed marine-derived fungi were from the species Aspergillus sp., Penicillium sp., Neosartorya sp., Dichotomomyces sp., Paradendryphiella sp., and Westerdykella sp. Additionally, Streptomyces sp. and Nocardiopsis sp. are actinobacteria discussed in this study. Seventy one compounds reviewed in this study were grouped on the basis of their chemical structures. Indole alkaloids and diketopiperazines made up most compounds with higher potencies when compared with other groups. The potency of indole alkaloids and diketopiperazines was most probably due to halogen-based functional groups and sulfide groups, respectively.


2021 ◽  
Author(s):  
Jiao Li ◽  
Chun-Lin Zhuang

The indole scaffold is one of the most important heterocyclic ring systems for pharmaceutical development, and serves as an active moiety in several clinical drugs. Fungi derived from marine origin are more liable to produce novel indole-containing natural products due to their extreme living environments. The indole alkaloids from marine fungi have drawn considerable attention for their unique chemical structures and significant biological activities. This review attempts to provide a summary of the structural diversity of marine fungal indole alkaloids including prenylated indoles, diketopiperazine indoles, bisindoles or trisindoles, quinazoline-containing indoles, indole-diterpenoids, and other indoles, as well as their known biological activities, mainly focusing on cytotoxic, kinase inhibitory, antiinflammatory, antimicrobial, anti-insecticidal, and brine shrimp lethal effects. A total of 306 indole alkaloids from marine fungi have been summarized, covering the references published from 1995 to early 2021, expecting to be beneficial for drug discovery in the future.


Marine Drugs ◽  
2021 ◽  
Vol 20 (1) ◽  
pp. 3
Author(s):  
Joko Tri Wibowo ◽  
Peni Ahmadi ◽  
Siti Irma Rahmawati ◽  
Asep Bayu ◽  
Masteria Yunovilsa Putra ◽  
...  

Novel secondary metabolites from marine macroorganisms and marine-derived microorganisms have been intensively investigated in the last few decades. Several classes of compounds, especially indole alkaloids, have been a target for evaluating biological and pharmacological activities. As one of the most promising classes of compounds, indole alkaloids possess not only intriguing structural features but also a wide range of biological/pharmacological activities including antimicrobial, anti-inflammatory, anticancer, antidiabetic, and antiparasitic activities. This review reports the indole alkaloids isolated during the period of 2016–2021 and their relevant biological/pharmacological activities. The marine-derived indole alkaloids reported from 2016 to 2021 were collected from various scientific databases. A total of 186 indole alkaloids from various marine organisms including fungi, bacteria, sponges, bryozoans, mangroves, and algae, are described. Despite the described bioactivities, further evaluation including their mechanisms of action and biological targets is needed to determine which of these indole alkaloids are worth studying to obtain lead compounds for the development of new drugs.


Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7457
Author(s):  
Xin Wei ◽  
Rui Guo ◽  
Xiao Wang ◽  
Jia-Jun Liang ◽  
Hao-Fei Yu ◽  
...  

The well-known toxic medicine Gelsemium elegans is widely and historically used to treat bone fracture and skin ulcers by the folk people of China. Two new monoterpenoid indole alkaloids, gelselegandines D and E, together with the known analogue gelegamine A were isolated from G. elegans. Their structures were elucidated by means of spectroscopic techniques and quantum chemical calculations. All isolated compounds were tested for the effects on RANKL-induced osteoclast formation. Interestingly, gelselegandine E and gelegamine A, respectively, showed significant promoting and inhibitory activities on osteoclastogenesis, while gelselegandine D had no activity under the same concentration. This work suggested the different configurations for the carbons near the C-19/20 oxygen rings of the isolated compounds may be the key active groups on osteoclast formation and provided the evidence for the rationality as the traditional treatment for bone-related diseases of G. elegans.


2021 ◽  
pp. 132277
Author(s):  
Yu-qi Li ◽  
Jing Cai ◽  
Jia-xin Cheng ◽  
Sheng-zhi Su ◽  
Toshihiro Akihisa ◽  
...  

Tetrahedron ◽  
2021 ◽  
pp. 132598
Author(s):  
Asif Wares Newaz ◽  
Kuo Yong ◽  
Xiao-Yuan Lian ◽  
Zhizhen Zhang

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Jingxian Feng ◽  
Doudou Huang ◽  
Yingbo Yang ◽  
Junfeng Chen ◽  
Shi Qiu ◽  
...  

AbstractIsatis indigotica Fort. (Chinese woad) is a species with an ancient and well-documented history as an indigo dye and medicinal plant. It is often confused with Isatis tinctoria L. (European woad), a medicinal plant in Europe. Here, the differences between I. indigotica and I. tinctoria are systematically described. The usage development history, clinical applications and pharmacological activities, and chemical components of I. indigotica are also summarized. Lignans, indole alkaloids, and their corresponding derivatives have been identified as the major active ingredients of I. indigotica and are associated with anti-viral, anti-inflammatory, anti-cancer, and other health-promoting activities. Notable progress has been made in understanding the biosynthetic pathway and regulation mechanism of lignans and indole alkaloids in I. indigotica, the results from which should facilitate the process of targeted metabolic engineering or synthetic biology. Moreover, multiple biotechnology methods such as polyploid breeding and genetic engineering have been used with I. indigotica to result in, for example, greater yields, higher levels of bioactive component accumulation, and enhanced stress tolerance to salt, drought, and insects. Some issues require additional analyses, and suggestions for future research on I. indigotica are also discussed.


Fitoterapia ◽  
2021 ◽  
pp. 105118
Author(s):  
Xiao-Feng Wang ◽  
Ren-Jie Wei ◽  
Qiang-Qiang Fang ◽  
Wan-Ying He ◽  
Kun Jiang ◽  
...  

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