W15.419 Seasonal variation of plasma glucose in hypertensive patients according to their nocturnal decline in blood pressure

Background: Telmisartan, an angiotensin II receptor blocker, has a higher affinity for AT1 receptors. It has also been recognized as partial agonist of the nuclear hormone receptor PPAR-gamma. The present study is conducted to study the effect of Telmisartan in hypertensive patients with impaired fasting glycaemia.Methods: This is a prospective and randomised study done on 50 hypertensive patients with impaired fasting glycaemia. All the patients underwent following investigations like Fasting plasma glucose, blood pressure and body mass index were also measured.Results: Fasting plasma glucose, blood pressure (SBP, DBP) showed significant decrease after intake of 40 mg Telmisartan for three months. Changes in BMI are not significant.Conclusions: The present study shows that Telmisartan is effective in controlling blood-pressure by its AT1 receptor blocking activity. It is also effective in decreasing fasting blood glucose by its insulin sensitizing activity through partial peroxisome proliferator activated receptor (PPAR) gamma activity.

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1009-195 The effect of seasonal variation of blood pressure when analyzing improvement and treating large groups of hypertensive patients

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(04)91894-3 ◽

2004 ◽

Vol 43 (5) ◽

pp. A449 ◽

Cited By ~ 1

Author(s):

Ross D Fletcher ◽

Madhulika Agarwal ◽

Christopher D McManus ◽

Vasilios Papademetriou ◽

Ronald E Jones

Keyword(s):

Blood Pressure ◽

Seasonal Variation ◽

Hypertensive Patients ◽

Large Groups

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Long-term amlodipine-based combination therapy attenuates seasonal variation of blood pressure in hypertensive patients

Clinical and Experimental Hypertension ◽

10.1080/10641963.2021.1960363 ◽

2021 ◽

pp. 1-8

Author(s):

Hua-song Xia ◽

Yue Liu ◽

Ju-xiang Li ◽

Hai Su ◽

Yan-qing Wu

Keyword(s):

Blood Pressure ◽

Seasonal Variation ◽

Combination Therapy ◽

Hypertensive Patients

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Sympatho—Adrenal and Cardiovascular Response to Mental Stress and Orthostatic Provocation in Latent Hypertension

Clinical Science ◽

10.1042/cs057189s ◽

1979 ◽

Vol 57 (s5) ◽

pp. 189s-191s ◽

Cited By ~ 26

Author(s):

P. Hjemdahl ◽

K. Eliasson

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Cyclic Amp ◽

Plasma Glucose ◽

Mental Stress ◽

Cardiovascular Response ◽

Physiological Responses ◽

Hypertensive Patients ◽

Noradrenaline And Adrenaline ◽

Noradrenaline Levels

1. Seven latent hypertensive patients and seven matched controls were subjected to standardized mental stress and orthostatic provocation. 2. Mental stress increased blood pressure by approximately 25%, heart rate by 25 beats/min, plasma glycerol by 50% and plasma cyclic AMP by 25% in both groups. Plasma glucose and renin activity were unchanged. Plasma noradrenaline and adrenaline were essentially unchanged during stress. 3. There was an insignificant tendency towards higher noradrenaline levels in latent hypertensive subjects and two of these subjects displayed an exaggerated noradrenaline response to standing. 4. Our results indicate that the physiological responses to mental stress are caused by selective neuronal activation, rather than by generalized sympatho-adrenal activation. Latent hypertension does not seem to be associated with adrenergic hyperactivity or receptor supersensitivity, except possibly in individual cases.

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