Treatment of Severe Meconium Aspiration Syndrome With Porcine Surfactant: A Multicentre, Randomized, Controlled Trial

2006 ◽  
Vol 2006 ◽  
pp. 137-138
Author(s):  
R.J. Rodriguez
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Meconium Aspiration Syndrome ◽  
Meconium Aspiration ◽  
Randomized Controlled

Randomized Controlled Trial of Lung Lavage with Dilute Surfactant for Meconium Aspiration Syndrome

2011 ◽  
Vol 158 (3) ◽  
pp. 383-389.e2 ◽  
Author(s):  
Peter A. Dargaville ◽  
Beverley Copnell ◽  
John F. Mills ◽  
Ismail Haron ◽  
Jimmy K.F. Lee ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Lung Lavage ◽  
Meconium Aspiration Syndrome ◽  
Meconium Aspiration ◽  
Randomized Controlled

Lung Lavage with Dilute Surfactant vs. Bolus Surfactant for Meconium Aspiration Syndrome

2019 ◽  
Vol 65 (5) ◽  
pp. 491-497 ◽  
Author(s):  
Sema Arayici ◽  
Fatma Nur Sari ◽  
Gulsum Kadioglu Simsek ◽  
Erbu Yarci ◽  
Evrim Alyamac Dizdar ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Lung Lavage ◽  
Meconium Aspiration Syndrome ◽  
Respiratory Support ◽  
High Frequency Ventilation ◽  
Clinical Trial Registration ◽  
Meconium Aspiration ◽  
Randomized Controlled ◽  
Frequency Ventilation ◽  
Respiratory Outcomes

Abstract Objective To compare the effectiveness of lung lavage with surfactant vs. bolus surfactant treatment in meconium aspiration syndrome (MAS). Patients and methods This randomized controlled trial included newborns ventilated with MAS. In lavage group (n = 17) 30 ml/kg of diluted porcine surfactant was instilled into the lung. In bolus group (n = 16) porcine surfactant (100 mg/kg) was administered as bolus. Respiratory outcomes and mortality were compared between groups. Results Duration of respiratory support was found to be similar between lavage and bolus groups (3 vs. 3.5 days, p = 0.36). Death or requirement for extracorporeal membrane oxygenation (ECMO) was 12% vs. 6%; respectively (RR: 2, 95% CI 0.16–24.48; p = 1.0). Duration of oxygen therapy, high-frequency ventilation or inhaled nitric oxide requirement did not differ among the groups. Conclusion Lung lavage did not show any advantage over bolus therapy on duration of respiratory support. The incidence of pneumothorax and surfactant re-administration decreased nonsignificantly in lavage group. Clinical Trial Registration We registered the trial to ClinicalTrials.gov (http://clinicaltrials.gov) under identifier NCT02041546. Registry name Lung Lavage With Dilute Poractant Alfa for Meconium Aspiration Syndrome.

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