After serving in Congress, Kelso resolved to open his own academy in Springfield. He supported the women’s suffrage movement in town. But he had borrowed heavily to build a large school building, and when few students enrolled, he was financially ruined. He ran for Congress again in 1868, but in a bitter campaign focused on monetary policy and filled with dirty tricks, he floundered and was badly beaten by his old nemesis, Pony Boyd. All of this only added to the strain of his marriage, already plagued by sexual problems and mutual jealousies. Kelso’s great tragedy, however, was not financial, political, or marital. In early September, 1870, his five-year-old son died suddenly from tetanus after stepping on a rusty rake. Only two weeks later, his fourteen-year-old son committed suicide. Kelso was shattered. The following year, his marriage in ruins, he took his eldest daughter Florella and headed west.