Discovery of Potent, Reversible, and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach

2019 ◽  
Vol 60 (2) ◽  
pp. 1028-1041 ◽  
Author(s):  
Mariana L. de Souza ◽  
Celso de Oliveira Rezende Junior ◽  
Rafaela S. Ferreira ◽  
Rocio Marisol Espinoza Chávez ◽  
Leonardo L. G. Ferreira ◽  
...  
Keyword(s):  
Drug Design ◽  
Design Approach ◽  
Structure Based Drug Design ◽  
Trypanocidal Activity ◽  
Cruzain Inhibitors

Carbamoyl Imidazoles As Potent, Reversible and Competitive Cruzain Inhibitors with in vitro and in vivo Trypanocidal Activity: A Structure-Based Drug Design Approach

2019 ◽  
Author(s):  
Mariana L. de Souza ◽  
Celso de Oliveira Rezende Junior ◽  
Rafaela S. Ferreira ◽  
Rocio Marisol Espinoza Chávez ◽  
Leonardo Ferreira ◽  
...  
Keyword(s):  
Drug Design ◽  
Design Approach ◽  
Structure Based Drug Design ◽  
Trypanocidal Activity ◽  
Cruzain Inhibitors

Design, synthesis and evaluation of diphenyl ether analogues as antitubercular agents

RSC Advances ◽  
2016 ◽  
Vol 6 (112) ◽  
pp. 110571-110582 ◽  
Author(s):  
Bharathkumar Inturi ◽  
Gurubasavaraj V. Pujar ◽  
Madhusudhan N. Purohit ◽  
Viswanathan B. Iyer ◽  
Sowmya G. S. ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Drug Design ◽  
Acyl Carrier Protein ◽  
Diphenyl Ether ◽  
Design Approach ◽  
Carrier Protein ◽  
Antitubercular Agents ◽  
Structure Based Drug Design ◽  
Design Synthesis ◽  
Diphenyl Ethers

We herein report the investigation of new diphenyl ethers asMycobacterium tuberculosisenoyl-acyl carrier protein reductase (InhA) inhibitors by structure-based drug design approach.

Novel Aldosterone Synthase Inhibitors with Extended Carbocyclic Skeleton by a Combined Ligand-Based and Structure-Based Drug Design Approach

2008 ◽  
Vol 51 (19) ◽  
pp. 6138-6149 ◽  
Author(s):  
Simon Lucas ◽  
Ralf Heim ◽  
Matthias Negri ◽  
Iris Antes ◽  
Christina Ries ◽  
...  
Keyword(s):  
Drug Design ◽  
Design Approach ◽  
Structure Based Drug Design ◽  
Aldosterone Synthase ◽  
Carbocyclic Skeleton

Mining ZINC Database to Discover Potential Phosphodiesterase 9 Inhibitors Using Structure-Based Drug Design Approach

2016 ◽  
Vol 12 (5) ◽  
pp. 472-477 ◽  
Author(s):  
Engi A. Hassaan ◽  
Sara C. Sigler ◽  
Tamer M. Ibrahim ◽  
Kevin J. Lee ◽  
Lauren K. Cichon ◽  
...  
Keyword(s):  
Drug Design ◽  
Design Approach ◽  
Structure Based Drug Design ◽  
Zinc Database

Identification of Dual Inhibitor of Phosphodiesterase 1B/10A using Structure-Based Drug Design Approach

2021 ◽  
pp. 117485
Author(s):  
Mayasah Al-Nema ◽  
Anand Gaurav ◽  
Vannajan Sanghiran Lee ◽  
Baskaran Gunasekaran ◽  
Ming Tatt Lee ◽  
...  
Keyword(s):  
Drug Design ◽  
Design Approach ◽  
Dual Inhibitor ◽  
Structure Based Drug Design
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