Design, Synthesis, and Characterization of Benzimidazole Derivatives as Positron Emission Tomography Imaging Ligands for Metabotropic Glutamate Receptor 2

Gengyang Yuan; Xiying Qu; Baohui Zheng; Ramesh Neelamegam; Sepideh Afshar; Suhasini Iyengar; Chuzhi Pan; Junfeng Wang; Hye Jin Kang; Mary Jo Ondrechen; Pekka Poutiainen; Georges El Fakhri; Zhaoda Zhang; Anna-Liisa Brownell

doi:10.1021/acs.jmedchem.0c01394

Design, Synthesis, and Characterization of Benzimidazole Derivatives as Positron Emission Tomography Imaging Ligands for Metabotropic Glutamate Receptor 2

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c01394 ◽

2020 ◽

Vol 63 (20) ◽

pp. 12060-12072

Author(s):

Gengyang Yuan ◽

Xiying Qu ◽

Baohui Zheng ◽

Ramesh Neelamegam ◽

Sepideh Afshar ◽

...

Keyword(s):

Metabotropic Glutamate Receptor ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Synthesis And Characterization ◽

Benzimidazole Derivatives ◽

Design Synthesis ◽

Tomography Imaging ◽

Metabotropic Glutamate ◽

Positron Emission

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In vivo positron emission tomography imaging with [11C]ABP688: binding variability and specificity for the metabotropic glutamate receptor subtype 5 in baboons

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-010-1723-7 ◽

2011 ◽

Vol 38 (6) ◽

pp. 1083-1094 ◽

Cited By ~ 39

Author(s):

Christine DeLorenzo ◽

Matthew S. Milak ◽

Kathleen G. Brennan ◽

J. S. Dileep Kumar ◽

J. John Mann ◽

...

Keyword(s):

Positron Emission Tomography ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Receptor Subtype ◽

Tomography Imaging ◽

Metabotropic Glutamate ◽

Positron Emission

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Synthesis and characterization of novel radiofluorinated probes for positron emission tomography imaging of monoamine oxidase B

Journal of Labelled Compounds and Radiopharmaceuticals ◽

10.1002/jlcr.3779 ◽

2019 ◽

Vol 62 (9) ◽

pp. 580-587 ◽

Cited By ~ 2

Author(s):

Mitsuyoshi Yoshimoto ◽

Masahiko Hirata ◽

Shinya Kagawa ◽

Yasuhiro Magata ◽

Yoshiro Ohmomo ◽

...

Keyword(s):

Positron Emission Tomography ◽

Monoamine Oxidase ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Synthesis And Characterization ◽

Monoamine Oxidase B ◽

Tomography Imaging ◽

Positron Emission

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Synthesis and characterization of the tetraazamacrocycle 4,10-dimethyl-1,4,7,10-tetraazacyclododecane-1,7-diacetic acid (H2Me2DO2A) and of its neutral copper(II) complex [Cu(Me2DO2A)]. A new 64Cu-labeled macrocyclic complex for positron emission tomography imaging †

Journal of the Chemical Society Dalton Transactions ◽

10.1039/b002441o ◽

2000 ◽

pp. 2393-2401 ◽

Cited By ~ 18

Author(s):

Pierluigi Barbaro ◽

Claudio Bianchini ◽

Geraldo Capannesi ◽

Lorella Di Luca ◽

Franco Laschi ◽

...

Keyword(s):

Positron Emission Tomography ◽

Positron Emission Tomography Imaging ◽

Macrocyclic Complex ◽

Emission Tomography ◽

Synthesis And Characterization ◽

Diacetic Acid ◽

Tomography Imaging ◽

Positron Emission

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Synthesis and Evaluation of Novel Radioligands Based on 3-[5-(Pyridin-2-yl)-2H-tetrazol-2-yl]benzonitrile for Positron Emission Tomography Imaging of Metabotropic Glutamate Receptor Subtype 5

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.6b00209 ◽

2016 ◽

Vol 59 (8) ◽

pp. 3980-3990 ◽

Cited By ~ 3

Author(s):

Yoko Shimoda ◽

Tomoteru Yamasaki ◽

Masayuki Fujinaga ◽

Masanao Ogawa ◽

Yusuke Kurihara ◽

...

Keyword(s):

Positron Emission Tomography ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Receptor Subtype ◽

Tomography Imaging ◽

Metabotropic Glutamate ◽

Positron Emission

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Synthesis and Characterization of a Positron Emission Tomography Imaging Probe Selectively Targeting the Second Bromodomain of Bromodomain Protein BRD4

Bioconjugate Chemistry ◽

10.1021/acs.bioconjchem.1c00245 ◽

2021 ◽

Author(s):

Ping Bai ◽

Yu Lan ◽

Hao Wang ◽

Yan Liu ◽

Robin Striar ◽

...

Keyword(s):

Positron Emission Tomography ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Synthesis And Characterization ◽

Tomography Imaging ◽

Imaging Probe ◽

Positron Emission

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Synthesis and evaluation of 6-[1-(2-[18F]fluoro-3-pyridyl)-5-methyl-1H-1,2,3-triazol-4-yl]quinoline for positron emission tomography imaging of the metabotropic glutamate receptor type 1 in brain

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2010.11.048 ◽

2011 ◽

Vol 19 (1) ◽

pp. 102-110 ◽

Cited By ~ 33

Author(s):

Masayuki Fujinaga ◽

Tomoteru Yamasaki ◽

Kazunori Kawamura ◽

Katsushi Kumata ◽

Akiko Hatori ◽

...

Keyword(s):

Positron Emission Tomography ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Receptor Type ◽

Tomography Imaging ◽

Metabotropic Glutamate ◽

Positron Emission

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Synthesis and Evaluation of Novel Radioligands for Positron Emission Tomography Imaging of Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Rodent Brain

Journal of Medicinal Chemistry ◽

10.1021/jm201590g ◽

2012 ◽

Vol 55 (5) ◽

pp. 2342-2352 ◽

Cited By ~ 27

Author(s):

Masayuki Fujinaga ◽

Tomoteru Yamasaki ◽

Joji Yui ◽

Akiko Hatori ◽

Lin Xie ◽

...

Keyword(s):

Positron Emission Tomography ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Receptor Subtype ◽

Tomography Imaging ◽

Metabotropic Glutamate ◽

Rodent Brain ◽

Positron Emission

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Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging

Journal of Medicinal Chemistry ◽

10.1021/jm300912k ◽

2012 ◽

Vol 55 (20) ◽

pp. 8685-8699 ◽

Cited By ~ 33

Author(s):

José-Ignacio Andrés ◽

Jesús Alcázar ◽

José María Cid ◽

Meri De Angelis ◽

Laura Iturrino ◽

...

Keyword(s):

Positron Emission Tomography ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Allosteric Modulators ◽

Tomography Imaging ◽

Metabotropic Glutamate ◽

Positron Emission ◽

Positive Allosteric Modulators

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Design, Synthesis, and Evaluation of (2-Aminocyclopropyl)phenyl Derivatives as Novel Positron Emission Tomography Imaging Agents for Lysine-Specific Demethylase 1 in the Brain

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c01937 ◽

2021 ◽

Vol 64 (7) ◽

pp. 3780-3793

Author(s):

Yasushi Hattori ◽

Satoru Matsuda ◽

Rina Baba ◽

Kouta Matsumiya ◽

Shinji Iwasaki ◽

...

Keyword(s):

Positron Emission Tomography ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Imaging Agents ◽

Design Synthesis ◽

Tomography Imaging ◽

Lysine Specific Demethylase ◽

Positron Emission ◽

The Brain

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Design, Synthesis, and Evaluation of 11C-Labeled 3-Acetyl-Indole Derivatives as a Novel Positron Emission Tomography Imaging Agent for Diacylglycerol Kinase Gamma (DGKγ) in Brain

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.1c00584 ◽

2021 ◽

Author(s):

Yasushi Hattori ◽

Tomoteru Yamasaki ◽

Tomohiro Ohashi ◽

Yuhei Miyanohana ◽

Tomokazu Kusumoto ◽

...

Keyword(s):

Positron Emission Tomography ◽

Positron Emission Tomography Imaging ◽

Diacylglycerol Kinase ◽

Emission Tomography ◽

Imaging Agent ◽

Indole Derivatives ◽

Design Synthesis ◽

Tomography Imaging ◽

Positron Emission

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