Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist

2021 ◽  
Author(s):  
Xishan Wu ◽  
Hui Shen ◽  
Yan Zhang ◽  
Chao Wang ◽  
Qiu Li ◽  
...  
Keyword(s):  
Benzimidazole Derivative ◽  
Inverse Agonist

Pharmacological Characterization of [3H]VUF11211, a Novel Radiolabeled Small-Molecule Inverse Agonist for the Chemokine Receptor CXCR3

2015 ◽  
Vol 87 (4) ◽  
pp. 639-648 ◽  
Author(s):  
Danny J. Scholten ◽  
Maikel Wijtmans ◽  
Jeffrey R. van Senten ◽  
Hans Custers ◽  
Ailas Stunnenberg ◽  
...  
Keyword(s):  
Small Molecule ◽  
Chemokine Receptor ◽  
Inverse Agonist ◽  
Pharmacological Characterization

Corrigendum to “Characterization of a new synthetic isoflavonoid with inverse agonist activity at the central benzodiazepine receptor” [Eur. J. Pharmacol. 495 (2004) 87–96]

2004 ◽  
Vol 502 (1-2) ◽  
pp. 157
Author(s):  
Daniele V.S. Lopes ◽  
Rodrigo R.B. Caruso ◽  
Newton G. Castro ◽  
Paulo R.R. Costa ◽  
Alcides J.M. da Silva ◽  
...  
Keyword(s):  
Benzodiazepine Receptor ◽  
Inverse Agonist ◽  
Agonist Activity ◽  
Central Benzodiazepine Receptor

Characterization of a selective inverse agonist for estrogen related receptor α as a potential agent for breast cancer

2016 ◽  
Vol 789 ◽  
pp. 439-448 ◽  
Author(s):  
Liudi Zhang ◽  
Peihong Liu ◽  
Haifei Chen ◽  
Qunyi Li ◽  
Lu Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Inverse Agonist ◽  
Estrogen Related Receptor

Characterization of polyamines having agonist, antagonist, and inverse agonist effects at the polyamine recognition site of the NMDA receptor

Neuron ◽  
1990 ◽  
Vol 5 (2) ◽  
pp. 199-208 ◽  
Author(s):  
Keith Williams ◽  
Valina L. Dawson ◽  
Carmelo Romano ◽  
Marc A. Dichter ◽  
Perry B. Molinoff
Keyword(s):  
Nmda Receptor ◽  
Inverse Agonist ◽  
Recognition Site

Binding Site Characterization of AM1336, a Novel Covalent Inverse Agonist at Human Cannabinoid 2 Receptor, Using Mass Spectrometric Analysis

2017 ◽  
Vol 16 (7) ◽  
pp. 2419-2428 ◽  
Author(s):  
Srikrishnan Mallipeddi ◽  
Simion Kreimer ◽  
Nikolai Zvonok ◽  
Kiran Vemuri ◽  
Barry L. Karger ◽  
...  
Keyword(s):  
Binding Site ◽  
Site Characterization ◽  
Inverse Agonist ◽  
Mass Spectrometric ◽  
Mass Spectrometric Analysis ◽  
Spectrometric Analysis

Discovery and Characterization of 6-{4-[3-(R)-2-Methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, Irdabisant): A Potent, Selective Histamine H3Receptor Inverse Agonist

2011 ◽  
Vol 54 (13) ◽  
pp. 4781-4792 ◽  
Author(s):  
Robert L. Hudkins ◽  
Rita Raddatz ◽  
Ming Tao ◽  
Joanne R. Mathiasen ◽  
Lisa D. Aimone ◽  
...  
Keyword(s):  
Inverse Agonist

Mechanistic characterization of S 38093, a novel inverse agonist at histamine H3 receptors

2017 ◽  
Vol 803 ◽  
pp. 11-23 ◽  
Author(s):  
Aurore Sors ◽  
Fany Panayi ◽  
Lionel Bert ◽  
Dominique Favale ◽  
Olivier Nosjean ◽  
...  
Keyword(s):  
Inverse Agonist ◽  
Histamine H3 Receptors ◽  
H3 Receptors ◽  
Histamine H3

In Vivo Characterization of 6β-Naltrexol, an Opioid Ligand with Less Inverse Agonist Activity Compared with Naltrexone and Naloxone in Opioid-Dependent Mice

2005 ◽  
Vol 313 (3) ◽  
pp. 1150-1162 ◽  
Author(s):  
Kirsten M. Raehal ◽  
John J. Lowery ◽  
Castigliano M. Bhamidipati ◽  
Ryan M. Paolino ◽  
Jennifer R. Blair ◽  
...  
Keyword(s):  
Inverse Agonist ◽  
Agonist Activity ◽  
In Vivo Characterization
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