Cation Radicals of Hachimoji Nucleobases. Canonical Purine and Noncanonical Pyrimidine Forms Generated in the Gas Phase and Characterized by UV–Vis Photodissociation Action Spectroscopy

2020 ◽  
Vol 124 (35) ◽  
pp. 7101-7112
Author(s):  
Shu R. Huang ◽  
František Tureček
Keyword(s):  
Gas Phase ◽  
Action Spectroscopy ◽  
Cation Radicals

Charge-Tagged Nucleosides in the Gas Phase: UV–Vis Action Spectroscopy and Structures of Cytidine Cations, Dications, and Cation Radicals

2021 ◽  
Author(s):  
Yue Liu ◽  
Congcong Ma ◽  
Gabriela Nováková ◽  
Aleš Marek ◽  
František Tureček
Keyword(s):  
Gas Phase ◽  
Action Spectroscopy ◽  
Cation Radicals

scholarly journals UV/Vis Action Spectroscopy and Structures of Tyrosine Peptide Cation Radicals in the Gas Phase

2016 ◽  
Vol 128 (26) ◽  
pp. 7595-7599 ◽  
Author(s):  
Emilie Viglino ◽  
Christopher J. Shaffer ◽  
František Tureček
Keyword(s):  
Gas Phase ◽  
Action Spectroscopy ◽  
Cation Radicals

Combining UV photodissociation action spectroscopy with electron transfer dissociation for structure analysis of gas-phase peptide cation-radicals

2015 ◽  
Vol 50 (12) ◽  
pp. 1438-1442 ◽  
Author(s):  
Christopher J. Shaffer ◽  
Robert Pepin ◽  
František Tureček
Keyword(s):  
Electron Transfer ◽  
Gas Phase ◽  
Structure Analysis ◽  
Electron Transfer Dissociation ◽  
Action Spectroscopy ◽  
Cation Radicals

scholarly journals UV/Vis Action Spectroscopy and Structures of Tyrosine Peptide Cation Radicals in the Gas Phase

2016 ◽  
Vol 55 (26) ◽  
pp. 7469-7473 ◽  
Author(s):  
Emilie Viglino ◽  
Christopher J. Shaffer ◽  
František Tureček
Keyword(s):  
Gas Phase ◽  
Action Spectroscopy ◽  
Cation Radicals

UV–Vis Action Spectroscopy of Guanine, 9-Methylguanine, and Guanosine Cation Radicals in the Gas Phase

2019 ◽  
Vol 123 (15) ◽  
pp. 3272-3284 ◽  
Author(s):  
Andy Dang ◽  
Yue Liu ◽  
František Tureček
Keyword(s):  
Gas Phase ◽  
Action Spectroscopy ◽  
Cation Radicals

scholarly journals Reactions between neutral molecules and cation-radicals in the gas-phase: Can protonation occur without proton transfer?

2015 ◽  
Vol 390 ◽  
pp. 39-48
Author(s):  
Yury V. Vasil’ev ◽  
Douglas F. Barofsky ◽  
Joseph S. Beckman ◽  
Benjamin J. Bythell
Keyword(s):  
Proton Transfer ◽  
Gas Phase ◽  
Cation Radicals

scholarly journals Electronic Spectroscopy of Isolated DNA Polyanions

2018 ◽  
Author(s):  
Steven Daly ◽  
Massimiliano Porrini ◽  
Frédéric Rosu ◽  
Valerie Gabelica
Keyword(s):  
Gas Phase ◽  
Absorption Spectra ◽  
Ion Mobility ◽  
Photoelectron Spectroscopy ◽  
Binding Energies ◽  
Action Spectroscopy ◽  
Action Spectra ◽  
Vis Spectroscopy ◽  
Electron Binding Energies ◽  
Electron Binding

In solution, UV-vis spectroscopy is often used to investigate structural changes in biomolecules (i.e., nucleic acids), owing to changes in the environment of their chromophores (i.e., the nucleobases). Here we address whether action spectroscopy could achieve the same for gas-phase ions, while taking the advantage of additional mass spectrometry and ion mobility separation of complex mixtures. We therefore systematically studied the action spectroscopy of homo-base 6-mer DNA strands (dG6, dA6, dC6, dT6), and discuss the results in light of gas-phase structures validated by ion mobility spectrometry and infrared ion spectroscopy, and in light of electron binding energies measured by photoelectron spectroscopy, and calculated electronic photo-absorption spectra. When UV photons interact with oligonucleotide polyanions, two main actions may take place: (1) fragmentation and (2) electron detachment. The action spectra reconstructed from fragmentation follow the absorption spectra well, and result from multiple cycles of absorption and internal conversion. The action spectra reconstructed from the electron photodetachment (EPD) efficiency reveal interesting phenomena: EPD depends on the charge state in a manner depending on electron binding energies, and is particularly efficient for purines but not pyrimidines. EPD thus reflects not only absorption, but also particular relaxation pathways of the electronic excited states. As these pathways lead to photo-oxidation, their investigation on model gas-phase systems may prove useful to elucidate mechanisms of photo-oxidative damages, which are linked to mutations and cancers.

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