Decellularized Liver Matrix-Modified Cryogel Scaffolds as Potential Hepatocyte Carriers in Bioartificial Liver Support Systems and Implantable Liver Constructs

2017 ◽  
Vol 10 (1) ◽  
pp. 114-126 ◽  
Author(s):  
Apeksha Damania ◽  
Anupam Kumar ◽  
Arun K. Teotia ◽  
Haruna Kimura ◽  
Masamichi Kamihira ◽  
...  
Keyword(s):  
Support Systems ◽  
Bioartificial Liver ◽  
Liver Support ◽  
Bioartificial Liver Support ◽  
Decellularized Liver

scholarly journals Uncertainty in the impact of liver support systems in acute-on-chronic liver failure: a systematic review and network meta-analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Klementina Ocskay ◽  
Anna Kanjo ◽  
Noémi Gede ◽  
Zsolt Szakács ◽  
Gabriella Pár ◽  
...  
Keyword(s):  
Liver Failure ◽  
Support Systems ◽  
Meta Analysis ◽  
Statistical Significance ◽  
Bioartificial Liver ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Liver Support ◽  
Bioartificial Liver Support ◽  
The Impact

Abstract Background The role of artificial and bioartificial liver support systems in acute-on-chronic liver failure (ACLF) is still controversial. We aimed to perform the first network meta-analysis comparing and ranking different liver support systems and standard medical therapy (SMT) in patients with ACLF. Methods The study protocol was registered with PROSPERO (CRD42020155850). A systematic search was conducted in five databases. We conducted a Bayesian network meta-analysis of randomized controlled trials assessing the effect of artificial or bioartificial liver support systems on survival in patients with ACLF. Ranking was performed by calculating the surface under cumulative ranking (SUCRA) curve values. The RoB2 tool and a modified GRADE approach were used for the assessment of the risk of bias and quality of evidence (QE). Results In the quantitative synthesis 16 trials were included, using MARS®, Prometheus®, ELAD®, plasma exchange (PE) and BioLogic-DT®. Overall (OS) and transplant-free (TFS) survival were assessed at 1 and 3 months. PE significantly improved 3-month OS compared to SMT (RR 0.74, CrI: 0.6–0.94) and ranked first on the cumulative ranking curves for both OS outcomes (SUCRA: 86% at 3 months; 77% at 1 month) and 3-month TFS (SUCRA: 87%) and second after ELAD for 1-month TFS (SUCRA: 76%). Other comparisons did not reach statistical significance. QE was moderate for PE concerning 1-month OS and both TFS outcomes. Other results were of very low certainty. Conclusion PE seems to be the best currently available liver support therapy in ACLF regarding 3-month OS. Based on the low QE, randomized trials are needed to confirm our findings for already existing options and to introduce new devices.

scholarly journals Clinical Application of Bioartificial Liver Support Systems

2004 ◽  
Vol 240 (2) ◽  
pp. 216-230 ◽  
Author(s):  
Maarten Paul van de Kerkhove ◽  
Ruurdtje Hoekstra ◽  
Robert A. F. M. Chamuleau ◽  
Thomas M. van Gulik
Keyword(s):  
Clinical Application ◽  
Support Systems ◽  
Bioartificial Liver ◽  
Liver Support ◽  
Bioartificial Liver Support

In Vitro Comparison of Two Bioartificial Liver Support Systems: MELS CellModule and AMC-BAL

2007 ◽  
Vol 30 (3) ◽  
pp. 183-191 ◽  
Author(s):  
P.P.C. Poyck ◽  
G. Pless ◽  
R. Hoekstra ◽  
S. Roth ◽  
A.C.W.A. Van Wijk ◽  
...  
Keyword(s):  
Support Systems ◽  
Bioartificial Liver ◽  
Liver Support ◽  
Bioartificial Liver Support ◽  
In Vitro Comparison

127 Preconditioning C3A cells for usage in bioartificial liver support systems

2004 ◽  
Vol 40 ◽  
pp. 45
Author(s):  
C. Filippi ◽  
S. Keatch ◽  
D. Rangar ◽  
P.C. Hayes ◽  
J.N. Plevris
Keyword(s):  
Support Systems ◽  
Bioartificial Liver ◽  
Liver Support ◽  
Bioartificial Liver Support

scholarly journals Bioartificial liver support systems for acute liver failure: A systematic review and meta-analysis of the clinical and preclinical literature

2019 ◽  
Vol 25 (27) ◽  
pp. 3634-3648 ◽  
Author(s):  
Yu-Ting He ◽  
Ya-Na Qi ◽  
Bing-Qi Zhang ◽  
Jian-Bo Li ◽  
Ji Bao
Keyword(s):  
Systematic Review ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Support Systems ◽  
Meta Analysis ◽  
Bioartificial Liver ◽  
Liver Support ◽  
Bioartificial Liver Support

Cryopreservation of primary porcine hepatocytes for use in bioartificial liver support systems

2000 ◽  
Vol 32 (7) ◽  
pp. 2271-2272 ◽  
Author(s):  
L Wu ◽  
J Sun ◽  
L Wang ◽  
C Wang ◽  
K Woodman ◽  
...  
Keyword(s):  
Support Systems ◽  
Bioartificial Liver ◽  
Liver Support ◽  
Bioartificial Liver Support ◽  
Porcine Hepatocytes

scholarly journals Analysis of Multivariables during Porcine Liver Digestion to Improve Hepatocyte Yield and Viability for Use in Bioartificial Liver Support Systems

2000 ◽  
Vol 9 (3) ◽  
pp. 329-336 ◽  
Author(s):  
Lisheng Wang ◽  
Junhong Sun ◽  
Chuanmin Wang ◽  
Kevin Woodman ◽  
Li Li ◽  
...  
Keyword(s):  
Support Systems ◽  
Bioartificial Liver ◽  
Porcine Liver ◽  
Liver Support ◽  
Bioartificial Liver Support
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