Improved Solid-Phase Synthesis of Phosphorylated Cellulose Microsphere Adsorbents for Highly Effective Pb2+ Removal from Water: Batch and Fixed-Bed Column Performance and Adsorption Mechanism

2017 ◽  
Vol 5 (6) ◽  
pp. 5108-5117 ◽  
Author(s):  
Xiaogang Luo ◽  
Jun Yuan ◽  
Yingge Liu ◽  
Chao Liu ◽  
Xingrong Zhu ◽  
...  
Keyword(s):  
Adsorption Mechanism ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Fixed Bed ◽  
Fixed Bed Column ◽  
Phase Synthesis ◽  
Highly Effective ◽  
Column Performance

Synthesis and Screening of A DNA-Encoded Library of Non-Peptidic Macrocycles

2020 ◽  
Author(s):  
Eric Koesema ◽  
Animesh Roy ◽  
Nicholas G. Paciaroni ◽  
Thomas Kodadek
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cell Permeability ◽  
Phase Synthesis ◽  
Protein Ligands ◽  
High Affinity ◽  
Scaffold Diversity

There is considerable interest in the development of libraries of non-peptidic macrocycles as a source of ligands for difficult targets. We report here the solid-phase synthesis of a DNA-encoded library of several hundred thousand thioether-linked macrocycles. The library was designed to be highly diverse with respect to backbone scaffold diversity and to minimize the number of amide N-H bonds, which compromise cell permeability. The utility of the library as a source of protein ligands is demonstrated through the isolation of compounds that bind streptavidin, a model target, with high affinity.

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