Interaction of Human AP Endonuclease 1 with Flap Endonuclease 1 and Proliferating Cell Nuclear Antigen Involved in Long-Patch Base Excision Repair

Biochemistry ◽  
2001 ◽  
Vol 40 (42) ◽  
pp. 12639-12644 ◽  
Author(s):  
Irina I. Dianova ◽  
Vilhelm A. Bohr ◽  
Grigory L. Dianov
Keyword(s):  
Base Excision Repair ◽  
Proliferating Cell Nuclear Antigen ◽  
Excision Repair ◽  
Nuclear Antigen ◽  
Ap Endonuclease ◽  
Flap Endonuclease 1 ◽  
Ap Endonuclease 1 ◽  
Base Excision ◽  
Proliferating Cell

scholarly journals Proliferating Cell Nuclear Antigen Facilitates Excision in Long-patch Base Excision Repair

1999 ◽  
Vol 274 (7) ◽  
pp. 4354-4363 ◽  
Author(s):  
Ronald Gary ◽  
Kyung Kim ◽  
Helen L. Cornelius ◽  
Min S. Park ◽  
Yoshihiro Matsumoto
Keyword(s):  
Base Excision Repair ◽  
Proliferating Cell Nuclear Antigen ◽  
Excision Repair ◽  
Nuclear Antigen ◽  
Base Excision ◽  
Proliferating Cell

scholarly journals AP Endonuclease 1 Coordinates Flap Endonuclease 1 and DNA Ligase I Activity in Long Patch Base Excision Repair

2002 ◽  
Vol 277 (44) ◽  
pp. 41715-41724 ◽  
Author(s):  
Tamara A. Ranalli ◽  
Samson Tom ◽  
Robert A. Bambara
Keyword(s):  
Base Excision Repair ◽  
Excision Repair ◽  
Dna Ligase ◽  
Ap Endonuclease ◽  
Flap Endonuclease 1 ◽  
Dna Ligase I ◽  
Ap Endonuclease 1 ◽  
Base Excision

Studies on the base excision repair (BER) complex in Pyrococcus furiosus

2009 ◽  
Vol 37 (1) ◽  
pp. 79-82 ◽  
Author(s):  
Shinichi Kiyonari ◽  
Saki Tahara ◽  
Maiko Uchimura ◽  
Tsuyoshi Shirai ◽  
Sonoko Ishino ◽  
...  
Keyword(s):  
Base Excision Repair ◽  
Pyrococcus Furiosus ◽  
Excision Repair ◽  
Repair Process ◽  
Nuclear Antigen ◽  
Physical Interaction ◽  
Ap Endonuclease ◽  
Reading Frame ◽  
Base Excision

We have been studying the functions of PCNA (proliferating-cell nuclear antigen) for the assembly and reassembly of the replisome during replication fork progression. We have identified the functional interactions between PCNA and several proteins involved in DNA replication and repair from Pyrococcus furiosus. We recently reported that the activity of UDG (uracil–DNA glycosylase) in P. furiosus (PfuUDG) is stimulated by PCNA (PfuPCNA) in vitro, and identified an atypical PCNA-binding site, AKTLF, in the PfuUDG protein. To understand further the function of the complex in the BER (base excision repair) process, we investigated the AP (apurinic/apyrimidinic) endonuclease, which can process the BER pathway after uracil removal by UDG. Interestingly, one candidate ORF (open reading frame) for the AP endonuclease was found in the operon containing the gene encoding UDG in the P. furiosus genome. However, this ORF did not exhibit any activity. Instead, we identified the AP endonuclease activity from the other candidate gene products, and designated the protein as PfuAP. We discovered a physical interaction between PfuAP and PfuPCNA, suggesting the formation of a BER complex in one of the repair systems in P. furiosus.

scholarly journals A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase β

2010 ◽  
Vol 39 (8) ◽  
pp. 3156-3165 ◽  
Author(s):  
De-Sheng Pei ◽  
Xiao-Jie Yang ◽  
Wei Liu ◽  
Jeroen E. J. Guikema ◽  
Carol E. Schrader ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Dna Polymerase Β ◽  
Ap Endonuclease ◽  
Regulatory Circuit ◽  
Ap Endonuclease 1 ◽  
Base Excision

scholarly journals AP endonuclease 1 prevents trinucleotide repeat expansion via a novel mechanism during base excision repair

2015 ◽  
Vol 43 (12) ◽  
pp. 5948-5960 ◽  
Author(s):  
Jill M. Beaver ◽  
Yanhao Lai ◽  
Meng Xu ◽  
Astrid H. Casin ◽  
Eduardo E. Laverde ◽  
...  
Keyword(s):  
Base Excision Repair ◽  
Trinucleotide Repeat ◽  
Excision Repair ◽  
Repeat Expansion ◽  
Trinucleotide Repeat Expansion ◽  
Ap Endonuclease ◽  
Ap Endonuclease 1 ◽  
Base Excision

scholarly journals AP endonuclease 1 prevents the extension of a T/G mismatch by DNA polymerase β to prevent mutations in CpGs during base excision repair

DNA Repair ◽  
2016 ◽  
Vol 43 ◽  
pp. 89-97 ◽  
Author(s):  
Yanhao Lai ◽  
Zhongliang Jiang ◽  
Jing Zhou ◽  
Emmanuel Osemota ◽  
Yuan Liu
Keyword(s):  
Dna Polymerase ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Dna Polymerase Β ◽  
Ap Endonuclease ◽  
Ap Endonuclease 1 ◽  
Base Excision

scholarly journals The human checkpoint sensor and alternative DNA clamp Rad9–Rad1–Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery

2005 ◽  
Vol 389 (1) ◽  
pp. 13-17 ◽  
Author(s):  
Ekaterina SMIRNOVA ◽  
Magali TOUEILLE ◽  
Enni MARKKANEN ◽  
Ulrich HÜBSCHER
Keyword(s):  
Quality Control ◽  
Dna Polymerase ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Dna Ligase ◽  
Dna Polymerase Β ◽  
Flap Endonuclease 1 ◽  
Important Target ◽  
Dna Ligase I ◽  
Base Excision

The human checkpoint sensor and alternative clamp Rad9–Rad1–Hus1 can interact with and specifically stimulate DNA ligase I. The very recently described interactions of Rad9–Rad1–Hus1 with MutY DNA glycosylase, DNA polymerase β and Flap endonuclease 1 now complete our view that the long-patch base excision machinery is an important target of the Rad9–Rad1–Hus1 complex, thus enhancing the quality control of DNA.

scholarly journals Spontaneous Mutagenesis Is Enhanced in Apex Heterozygous Mice

2004 ◽  
Vol 24 (18) ◽  
pp. 8145-8153 ◽  
Author(s):  
Jessica Huamani ◽  
C. Alex McMahan ◽  
Damon C. Herbert ◽  
Robert Reddick ◽  
John R. McCarrey ◽  
...  
Keyword(s):  
Base Excision Repair ◽  
Germ Line ◽  
Excision Repair ◽  
Spontaneous Mutant ◽  
Spermatogenic Cells ◽  
Ap Endonuclease ◽  
Repair Activity ◽  
Base Excision ◽  
Mutant Frequency

ABSTRACT Germ line DNA directs the development of the next generation and, as such, is profoundly different from somatic cell DNA. Spermatogenic cells obtained from young adult lacI transgenic mice display a lower spontaneous mutant frequency and greater in vitro base excision repair activity than somatic cells and tissues obtained from the same mice. However, spermatogenic cells from old lacI mice display a 10-fold higher mutant frequency. This increased spontaneous mutant frequency occurs coincidentally with decreased in vitro base excision repair activity for germ cell and testicular extracts that in turn corresponds to a decreased abundance of AP endonuclease. To directly test whether a genetic diminution of AP endonuclease results in increased spontaneous mutant frequencies in spermatogenic cell types, AP endonuclease heterozygous (Apex +/−) knockout mice were crossed with lacI transgenic mice. Spontaneous mutant frequencies were significantly elevated (approximately twofold) for liver and spleen obtained from 3-month-old Apex +/− lacI + mice compared to frequencies from Apex +/+ lacI + littermates and were additionally elevated for somatic tissues from 9-month-old mice. Spermatogenic cells from 9-month-old Apex +/− lacI + mice were significantly elevated twofold compared to levels for 9-month-old Apex +/+ lacI + control mice. These data indicate that diminution of AP endonuclease has a significant effect on spontaneous mutagenesis in somatic and germ line cells.

scholarly journals Flap Endonuclease 1 Efficiently Cleaves Base Excision Repair and DNA Replication Intermediates Assembled into Nucleosomes

2002 ◽  
Vol 10 (5) ◽  
pp. 1201-1211 ◽  
Author(s):  
Christine F Huggins ◽  
David R Chafin ◽  
Sayura Aoyagi ◽  
Leigh A Henricksen ◽  
Robert A Bambara ◽  
...  
Keyword(s):  
Dna Replication ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Flap Endonuclease 1 ◽  
Base Excision ◽  
Replication Intermediates
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