Selective Activation of the 20 S Proteasome (Multicatalytic Proteinase Complex) by Histone H3†

Biochemistry ◽  
2001 ◽  
Vol 40 (50) ◽  
pp. 15318-15326 ◽  
Author(s):  
Marian Orlowski
Keyword(s):  
Histone H3 ◽  
Selective Activation ◽  
Multicatalytic Proteinase ◽  
Multicatalytic Proteinase Complex

scholarly journals Common epitopes of bovine lens multicatalytic-proteinase-complex subunits

1989 ◽  
Vol 257 (1) ◽  
pp. 265-269 ◽  
Author(s):  
B J Wagner ◽  
J W Margolis
Keyword(s):  
Gel Electrophoresis ◽  
Affinity Purification ◽  
Polyacrylamide Gel Electrophoresis ◽  
Polyclonal Antiserum ◽  
Antibody Affinity ◽  
Multicatalytic Proteinase ◽  
Bovine Lens ◽  
The Common ◽  
Multicatalytic Proteinase Complex ◽  
Monospecific Antibodies

Component polypeptides of both the bovine lens and pituitary multicatalytic proteinase complexes demonstrate different immunoreactivities with a polyclonal antiserum raised against the purified pituitary enzyme. Four (Mr 24000, 26000, 34000 and 38000) of eight bands that have been resolved by SDS/polyacrylamide-gel electrophoresis are stained in immunoblot experiments. Monospecific antibodies obtained from this antiserum by affinity purification from the 38000- and 34000-Mr bands of the lens enzyme bound equally well to either band, but showed little or no binding to the 26000- and 24000-Mr bands upon immunoblotting. Antibody affinity-purified from the 24000-Mr band showed comparable binding to the 24000-, 34000- or 38000-Mr band. One explanation of these results is that the 24000-Mr polypeptide is derived from the higher-Mr polypeptide(s) and has lost some of the common immunodeterminants.

Synthetic Inhibitors of the Multicatalytic Proteinase Complex (Proteasome)

1993 ◽  
Vol 47 (4-6) ◽  
pp. 306-313 ◽  
Author(s):  
Sherwin Wilk ◽  
Maria E. Figueiredo-Pereira
Keyword(s):  
Multicatalytic Proteinase ◽  
Multicatalytic Proteinase Complex

Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex

Biochemistry ◽  
1992 ◽  
Vol 31 (39) ◽  
pp. 9421-9428 ◽  
Author(s):  
Alexander Vinitsky ◽  
Charlene Michaud ◽  
James C. Powers ◽  
Marian Orlowski
Keyword(s):  
Multicatalytic Proteinase ◽  
Multicatalytic Proteinase Complex
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