Role of Glutamic Acid 216 in Cytochrome P450 2D6 Substrate Binding and Catalysis†

Biochemistry ◽  
2003 ◽  
Vol 42 (5) ◽  
pp. 1245-1253 ◽  
Author(s):  
F. Peter Guengerich ◽  
Imad H. Hanna ◽  
Martha V. Martin ◽  
Elizabeth M. J. Gillam
Keyword(s):  
Cytochrome P450 ◽  
Glutamic Acid ◽  
Substrate Binding ◽  
Cytochrome P450 2D6 ◽  
P450 2D6

Topological role of cytochrome P450 2D6 active site residues

2006 ◽  
Vol 447 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Robert A.B. van Waterschoot ◽  
Peter H.J. Keizers ◽  
Chris de Graaf ◽  
Nico P.E. Vermeulen ◽  
Richard A. Tschirret-Guth
Keyword(s):  
Cytochrome P450 ◽  
Active Site ◽  
Cytochrome P450 2D6 ◽  
Active Site Residues ◽  
P450 2D6

Role of cytochrome P450 2D6 (CYP2D6) in the stereospecific metabolism of E- and Z-doxepin

2000 ◽  
Vol 10 (7) ◽  
pp. 591-603 ◽  
Author(s):  
V. S. Haritos ◽  
H. Ghabrial ◽  
J. T. Ahokas ◽  
M. S. Ching
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 2D6 ◽  
P450 2D6

Role of the conserved threonine 309 in mechanism of oxidation by cytochrome P450 2D6

2005 ◽  
Vol 338 (2) ◽  
pp. 1065-1074 ◽  
Author(s):  
Peter H.J. Keizers ◽  
Loek H.M. Schraven ◽  
Chris de Graaf ◽  
Mats Hidestrand ◽  
Magnus Ingelman-Sundberg ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 2D6 ◽  
Mechanism Of Oxidation ◽  
P450 2D6

The role of cytochrome P450 2D6 in the metabolism of moclobemide

1996 ◽  
Vol 6 (3) ◽  
pp. 225-230 ◽  
Author(s):  
Sebastian Härtter ◽  
Jasper Dingemanse ◽  
Dieter Baier ◽  
Gismar Ziegler ◽  
Christoph Hiemke
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 2D6 ◽  
P450 2D6

Roles of phenylalanine at position 120 and glutamic acid at position 222 in the oxidation of chiral substrates by cytochrome P450 2D6

Chirality ◽  
2006 ◽  
Vol 18 (3) ◽  
pp. 167-176 ◽  
Author(s):  
Kazufumi Masuda ◽  
Keietsu Tamagake ◽  
Takashi Katsu ◽  
Fumihiro Torigoe ◽  
Keita Saito ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Glutamic Acid ◽  
Cytochrome P450 2D6 ◽  
P450 2D6

The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependent

2005 ◽  
Vol 70 (8) ◽  
pp. 1253-1261 ◽  
Author(s):  
Barbara M.A. Lussenburg ◽  
Peter H.J. Keizers ◽  
Chris de Graaf ◽  
Mats Hidestrand ◽  
M. Ingelman-Sundberg ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 2D6 ◽  
P450 2D6
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