BeiGene pays Ambrx for unusual amino acids

2019 ◽  
Vol 97 (11) ◽  
pp. 13-13
Keyword(s):  
Amino Acids ◽  
Unusual Amino Acids

Val-Geninthiocin: Structure Elucidation and MSn Fragmentation of Thiopeptide Antibiotics Produced by Streptomyces sp. RSF18

2008 ◽  
Vol 63 (10) ◽  
pp. 1223-1230 ◽  
Author(s):  
Imran Sajid ◽  
Khaled A. Shaaban ◽  
Holm Frauendorf ◽  
Shahida Hasnain ◽  
Hartmut Laatscha
Keyword(s):  
Amino Acids ◽  
Biological Activity ◽  
Antifungal Activity ◽  
Structure Elucidation ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Unusual Amino Acids ◽  
Streptomyces Sp ◽  
Gram Positive Bacteria ◽  
Thiopeptide Antibiotics

AbstractVal-Geninthiocin (2), a new member of thiopeptide antibiotics, was isolated from the mycelium of Streptomyces sp. RSF18, along with the closely related geninthiocin (1) and the macrolide, chalcomycin. By intensive NMR and MS studies, Val-geninthiocin (2) was identified as desoxygeninthiocin, a thiopeptide, containing several oxazole and thiazole units and a number of unusual amino acids. Compound 2 shows potent activity against Gram-positive bacteria and minor antifungal activity, while it is not effective against Gram-negative bacteria or microalgae. Here we describe the fermentation, isolation and structure elucidation as well as the biological activity of 2.

Biosynthesis of polyesters from some unusual amino acids having linear carbon skeleton by Alcaligenes eutrophus

1994 ◽  
Vol 195 (11) ◽  
pp. 3699-3707 ◽  
Author(s):  
Yoshio Inoue ◽  
Masayuku Fujita ◽  
Osamu Ohta ◽  
Kazuhiro Nakamura ◽  
Hiroko Kuroki ◽  
...  
Keyword(s):  
Amino Acids ◽  
Alcaligenes Eutrophus ◽  
Carbon Skeleton ◽  
Unusual Amino Acids

Bradykinin antagonists containing unusual amino acids show long-lasting action in vivo

Peptides ◽  
1994 ◽  
pp. 449-451
Author(s):  
L. Gera ◽  
V. Srivastava ◽  
F. W. Dunn ◽  
J. M. Stewart
Keyword(s):  
Amino Acids ◽  
Unusual Amino Acids ◽  
Bradykinin Antagonists

Asymmetric synthesis of unusual amino acids designed for topographical control of peptide conformation

Peptides ◽  
1992 ◽  
pp. 768-770 ◽  
Author(s):  
K. C. Russell ◽  
W. M. Kazmierski ◽  
E. Nicolas ◽  
R. D. Ferguson ◽  
J. Knollenberg ◽  
...  
Keyword(s):  
Amino Acids ◽  
Asymmetric Synthesis ◽  
Peptide Conformation ◽  
Unusual Amino Acids

Unusual amino acids IV. Asymmetric synthesis of thienylalanines

1993 ◽  
Vol 4 (8) ◽  
pp. 1833-1842 ◽  
Author(s):  
Christian Döbler ◽  
H.-J. Kreuzfeld ◽  
H.W. Krause ◽  
M. Michalik
Keyword(s):  
Amino Acids ◽  
Asymmetric Synthesis ◽  
Unusual Amino Acids

ChemInform Abstract: Unusual Amino Acids. Part 5. Synthesis of 3,5-Dioxopyrazolidine Derivatives.

ChemInform ◽  
2010 ◽  
Vol 32 (21) ◽  
pp. no-no
Author(s):  
D. Zicane ◽  
Z. Tetere ◽  
I. Rijkure ◽  
M. V. Petrova ◽  
E. Gudriniece ◽  
...  
Keyword(s):  
Amino Acids ◽  
Unusual Amino Acids
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