Non-peptide angiotensin II receptor antagonists. 1. Design, synthesis, and biological activity of N-substituted indoles and dihydroindoles

Daljit S. Dhanoa; Scott W. Bagley; Raymond S. L. Chang; Victor J. Lotti; Tsing Bau Chen; Salah D. Kivlighn; Gloria J. Zingaro; Peter K. S. Siegl; Arthur A. Patchett; William J. Greenlee

doi:10.1021/jm00078a013

Non-peptide angiotensin II receptor antagonists. 1. Design, synthesis, and biological activity of N-substituted indoles and dihydroindoles

Journal of Medicinal Chemistry ◽

10.1021/jm00078a013 ◽

1993 ◽

Vol 36 (26) ◽

pp. 4230-4238 ◽

Cited By ~ 21

Author(s):

Daljit S. Dhanoa ◽

Scott W. Bagley ◽

Raymond S. L. Chang ◽

Victor J. Lotti ◽

Tsing Bau Chen ◽

...

Keyword(s):

Biological Activity ◽

Angiotensin Ii ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Design Synthesis

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Non-peptide angiotensin II receptor antagonists. 2. Design, synthesis, and biological activity of N-substituted (phenylamino)phenylacetic acids and acyl sulfonamides. [Erratum to document cited in CA120(5):45190z]

Journal of Medicinal Chemistry ◽

10.1021/jm00033a021 ◽

1994 ◽

Vol 37 (7) ◽

pp. 1034-1034

Author(s):

Daljit S. Dhanoa ◽

Scott W. Bagley ◽

Raymond S. L. Chang ◽

Victor J. Lotti ◽

Tsing Bau Chen ◽

...

Keyword(s):

Biological Activity ◽

Angiotensin Ii ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Design Synthesis

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Non-peptide angiotensin II receptor antagonists. 2. Design, synthesis, and biological activity of N-substituted (phenylamino)phenylacetic acids and acyl sulfonamides

Journal of Medicinal Chemistry ◽

10.1021/jm00078a014 ◽

1993 ◽

Vol 36 (26) ◽

pp. 4239-4249 ◽

Cited By ~ 15

Author(s):

Daljit S. Dhanoa ◽

Scott W. Bagley ◽

Raymond S. L. Chang ◽

Victor J. Lotti ◽

Tsing Bau Chen ◽

...

Keyword(s):

Biological Activity ◽

Angiotensin Ii ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Design Synthesis

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Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-l-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-4-[2-(trifluoroacetyl)-1H-pyrrol-1-yl]-1H-imidazole-5-carboxylic acid (CI-996)

Journal of Medicinal Chemistry ◽

10.1021/jm00068a002 ◽

1993 ◽

Vol 36 (16) ◽

pp. 2253-2265 ◽

Cited By ~ 9

Author(s):

Ila Sircar ◽

John C. Hodges ◽

John Quin ◽

Amy M. Bunker ◽

R. Thomas Winters ◽

...

Keyword(s):

Angiotensin Ii ◽

Carboxylic Acid ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Imidazole Derivatives ◽

Structure Activity

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Design, synthesis, and evaluation of novelly substituted benzimidazole compounds as angiotensin II receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2005.05.054 ◽

2005 ◽

Vol 15 (17) ◽

pp. 3962-3965 ◽

Cited By ~ 26

Author(s):

Alka Bali ◽

Yogita Bansal ◽

M. Sugumaran ◽

Jatinder Singh Saggu ◽

P. Balakumar ◽

...

Keyword(s):

Angiotensin Ii ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Design Synthesis

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6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships

Journal of Medicinal Chemistry ◽

10.1021/jm00077a007 ◽

1993 ◽

Vol 36 (25) ◽

pp. 4040-4051 ◽

Cited By ~ 130

Author(s):

Uwe J. Ries ◽

Gerhard Mihm ◽

Berthold Narr ◽

Kai M. Hasselbach ◽

Helmut Wittneben ◽

...

Keyword(s):

Biological Activity ◽

Angiotensin Ii ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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Novel Angiotensin II Receptor Antagonists. Design, Synthesis, and in Vitro Evaluation of Dibenzo[a,d]cycloheptene and Dibenzo[b,f]oxepin Derivatives. Searching for Bioisosteres of Biphenyltetrazole Using a Three-Dimensional Search Technique

Journal of Medicinal Chemistry ◽

10.1021/jm00014a024 ◽

1995 ◽

Vol 38 (14) ◽

pp. 2728-2741 ◽

Cited By ~ 38

Author(s):

Ryuichi Kiyama ◽

Tsunetoshi Honma ◽

Kunio Hayashi ◽

Masayoshi Ogawa ◽

Mariko Hara ◽

...

Keyword(s):

Angiotensin Ii ◽

Three Dimensional ◽

Angiotensin Ii Receptor ◽

Search Technique ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Design Synthesis ◽

In Vitro Evaluation

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ChemInform Abstract: Nonpeptide Angiotensin II Receptor Antagonists: Synthesis and Biological Activity of 1H-Imidazo (cf. (I)) and 1H-(1,2,3)-Triazolo Fused Derivatives (cf. (II)).

ChemInform ◽

10.1002/chin.199739154 ◽

2010 ◽

Vol 28 (39) ◽

pp. no-no

Author(s):

F. DELGADO ◽

J. PASTOR ◽

J. L. GARCIA-NAVIO ◽

J. J. VAQUERO ◽

J. ALVAREZ-BUILLA ◽

...

Keyword(s):

Biological Activity ◽

Angiotensin Ii ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists

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Design, synthesis, and evaluation of 5-sulfamoyl benzimidazole derivatives as novel angiotensin II receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2008.10.056 ◽

2008 ◽

Vol 16 (24) ◽

pp. 10210-10215 ◽

Cited By ~ 24

Author(s):

Navneet Kaur ◽

Amardeep Kaur ◽

Yogita Bansal ◽

Dhvanit I. Shah ◽

Gulshan Bansal ◽

...

Keyword(s):

Angiotensin Ii ◽

Benzimidazole Derivatives ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Design Synthesis

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ChemInform Abstract: Nonpeptide Angiotensin II Receptor Antagonists. Part 2. Design, Synthesis, and Structure-Activity Relationships of 2-Alkyl-4-(1H-pyrrol-1-yl)-1H-imidazole Derivatives: Profile of 2-Propyl-1-((2′-(1H-tetrazol-5-yl)-(1,1′-biphenyl)-4-yl

ChemInform ◽

10.1002/chin.199352180 ◽

2010 ◽

Vol 24 (52) ◽

pp. no-no

Author(s):

I. SIRCAR ◽

J. C. HODGES ◽

J. III QUIN ◽

A. M. BUNKER ◽

R. T. WINTERS ◽

...

Keyword(s):

Angiotensin Ii ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Imidazole Derivatives ◽

Structure Activity

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Design, Synthesis, and Evaluation of Novelly Substituted Benzimidazole Compounds as Angiotensin II Receptor Antagonists.

ChemInform ◽

10.1002/chin.200550122 ◽

2005 ◽

Vol 36 (50) ◽

Author(s):

Alka Bali ◽

Yogita Bansal ◽

M. Sugumaran ◽

Jatinder Singh Saggu ◽

P. Balakumar ◽

...

Keyword(s):

Angiotensin Ii ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Design Synthesis

Download Full-text