Structure-activity relationships of the antimalarial agent artemisinin. 1. Synthesis and comparative molecular field analysis of C-9 analogs of artemisinin and 10-deoxoartemisinin

Mitchell A. Avery; Fenglan Gao; Wesley K. M. Chong; Sanjiv Mehrotra; Wilbur K. Milhous

doi:10.1021/jm00078a017

Structure-activity relationships of the antimalarial agent artemisinin. 1. Synthesis and comparative molecular field analysis of C-9 analogs of artemisinin and 10-deoxoartemisinin

Journal of Medicinal Chemistry ◽

10.1021/jm00078a017 ◽

1993 ◽

Vol 36 (26) ◽

pp. 4264-4275 ◽

Cited By ~ 65

Author(s):

Mitchell A. Avery ◽

Fenglan Gao ◽

Wesley K. M. Chong ◽

Sanjiv Mehrotra ◽

Wilbur K. Milhous

Keyword(s):

Field Analysis ◽

Molecular Field ◽

Comparative Molecular Field Analysis ◽

Antimalarial Agent ◽

Structure Activity Relationships ◽

Molecular Field Analysis ◽

Structure Activity

Download Full-text

3D-Quantitative Structure-Activity Relationships: Nonlinear Dependence Described Directly from 3D Structures Using a Comparative Molecular Field Analysis (CoMFA) Approach

Quantitative Structure-Activity Relationships ◽

10.1002/qsar.2660110302 ◽

1992 ◽

Vol 11 (3) ◽

pp. 309-317 ◽

Cited By ~ 15

Author(s):

Ki Hwan Kim

Keyword(s):

Field Analysis ◽

Molecular Field ◽

Nonlinear Dependence ◽

Comparative Molecular Field Analysis ◽

Quantitative Structure ◽

3D Structures ◽

Structure Activity Relationships ◽

Molecular Field Analysis ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

Download Full-text

3D-Quantitative Structure-Activity Relationships: Describing Hydrophobic Interactions Directly from 3D Structures Using a Comparative Molecular Field Analysis (CoMFA) Approach

Quantitative Structure-Activity Relationships ◽

10.1002/qsar.19930120303 ◽

1993 ◽

Vol 12 (3) ◽

pp. 232-238 ◽

Cited By ~ 21

Author(s):

Ki Hwan Kim

Keyword(s):

Hydrophobic Interactions ◽

Field Analysis ◽

Molecular Field ◽

Comparative Molecular Field Analysis ◽

Quantitative Structure ◽

3D Structures ◽

Structure Activity Relationships ◽

Molecular Field Analysis ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

Download Full-text

Quantitative structure-activity relationships of light-dependent herbicidal 4-pyridone-3-carboxanilides III. 3-D (comparative molecular field) analysis including light-dependent diphenyl ether herbicides

Pesticide Science ◽

10.1002/ps.2780350215 ◽

1992 ◽

Vol 35 (2) ◽

pp. 187-200 ◽

Cited By ~ 4

Author(s):

Hirokazu Osabe ◽

Yasuo Morishima ◽

Yukihisa Goto ◽

Toshio Fujita

Keyword(s):

Diphenyl Ether ◽

Field Analysis ◽

Molecular Field ◽

Comparative Molecular Field Analysis ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Molecular Field Analysis ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

Download Full-text

Structure−Activity Relationships at Monoamine Transporters for a Series of N-Substituted 3α-(Bis[4-fluorophenyl]methoxy)tropanes: Comparative Molecular Field Analysis, Synthesis, and Pharmacological Evaluation

Journal of Medicinal Chemistry ◽

10.1021/jm030646c ◽

2004 ◽

Vol 47 (13) ◽

pp. 3388-3398 ◽

Cited By ~ 29

Author(s):

Santosh S. Kulkarni ◽

Peter Grundt ◽

Theresa Kopajtic ◽

Jonathan L. Katz ◽

Amy Hauck Newman

Keyword(s):

Field Analysis ◽

Molecular Field ◽

Comparative Molecular Field Analysis ◽

Monoamine Transporters ◽

Structure Activity Relationships ◽

Pharmacological Evaluation ◽

Molecular Field Analysis ◽

Structure Activity

Download Full-text

3D-Quantitative Structure-Activity Relationships: Investigation of Steric Effects with Descriptors Directly from 3D Structures Using a Comparative Molecular Field Analysis (CoMFA) Approach

Quantitative Structure-Activity Relationships ◽

10.1002/qsar.2660110402 ◽

1992 ◽

Vol 11 (4) ◽

pp. 453-460 ◽

Cited By ~ 13

Author(s):

Ki Hwan Kim

Keyword(s):

Field Analysis ◽

Molecular Field ◽

Steric Effects ◽

Comparative Molecular Field Analysis ◽

Quantitative Structure ◽

3D Structures ◽

Structure Activity Relationships ◽

Molecular Field Analysis ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

Download Full-text

Three Dimensional Quantitative Structure-Activity Relationships of Sulfonamides Binding Monoclonal Antibody by Comparative Molecular Field Analysis

Nature Precedings ◽

10.1038/npre.2008.2646.1 ◽

2008 ◽

Author(s):

Zhanhui Wang ◽

Xingyuan Cao ◽

Zhenpeng Kai ◽

Ross Beier ◽

Congming Wu ◽

...

Keyword(s):

Monoclonal Antibody ◽

Three Dimensional ◽

Field Analysis ◽

Molecular Field ◽

Comparative Molecular Field Analysis ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Molecular Field Analysis ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

Download Full-text

3D-Quantitative Structure-Activity Relationships: Description of Electronic Effects Directly from 3D Structures Using a GRID-Comparative Molecular Field Analysis (CoMFA) Approach

Quantitative Structure-Activity Relationships ◽

10.1002/qsar.19920110202 ◽

1992 ◽

Vol 11 (2) ◽

pp. 127-134 ◽

Cited By ~ 21

Author(s):

Ki Hwan Kim

Keyword(s):

Field Analysis ◽

Molecular Field ◽

Comparative Molecular Field Analysis ◽

Quantitative Structure ◽

Electronic Effects ◽

3D Structures ◽

Structure Activity Relationships ◽

Molecular Field Analysis ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

Download Full-text

Mechanistic interpretation of the genotoxicity of nitrofurans (antibacterial agents) using quantitative structure-activity relationships and comparative molecular field analysis

Journal of Medicinal Chemistry ◽

10.1021/jm00060a008 ◽

1993 ◽

Vol 36 (8) ◽

pp. 1007-1016 ◽

Cited By ~ 58

Author(s):

Asim Kumar Debnath ◽

Corwin Hansch ◽

Ki H. Kim ◽

Yvonne C. Martin

Keyword(s):

Antibacterial Agents ◽

Field Analysis ◽

Molecular Field ◽

Comparative Molecular Field Analysis ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Molecular Field Analysis ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

Download Full-text

Three-Dimensional Quantitative Structure−Activity Relationships of Cyclo-oxygenase-2 (COX-2) Inhibitors: A Comparative Molecular Field Analysis

Journal of Medicinal Chemistry ◽

10.1021/jm0101343 ◽

2001 ◽

Vol 44 (20) ◽

pp. 3223-3230 ◽

Cited By ~ 76

Author(s):

Philippe Chavatte ◽

Saïd Yous ◽

Christophe Marot ◽

Nicolas Baurin ◽

Daniel Lesieur

Keyword(s):

Three Dimensional ◽

Field Analysis ◽

Molecular Field ◽

Comparative Molecular Field Analysis ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Cox 2 ◽

Quantitative Structure Activity Relationships ◽

Cox 2 Inhibitors

Download Full-text

Quantitative Structure-Activity Relationships/Comparative Molecular Field Analysis (QSAR/CoMFA) for Receptor-Binding Properties of Halogenated Estradiol Derivatives

Journal of Medicinal Chemistry ◽

10.1021/jm00050a013 ◽

1994 ◽

Vol 37 (24) ◽

pp. 4164-4176 ◽

Cited By ~ 57

Author(s):

Tsvetan G. Gantchev ◽

Hasrat Ali ◽

Johan E. van Lier

Keyword(s):

Receptor Binding ◽

Field Analysis ◽

Molecular Field ◽

Comparative Molecular Field Analysis ◽

Quantitative Structure ◽

Binding Properties ◽

Structure Activity Relationships ◽

Structure Activity ◽

Estradiol Derivatives ◽

Quantitative Structure Activity Relationships

Download Full-text