Irreversible enzyme inhibitors. CLI. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-(p-aminophenylbutyl)-2,4-diaminopyrimidines with a terminal phenylene sulfonyl fluoride

Bernard Randall Baker; Rich B. Meyer

doi:10.1021/jm00302a007

Irreversible enzyme inhibitors. CLI. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-(p-aminophenylbutyl)-2,4-diaminopyrimidines with a terminal phenylene sulfonyl fluoride

Journal of Medicinal Chemistry ◽

10.1021/jm00302a007 ◽

1969 ◽

Vol 12 (2) ◽

pp. 224-227 ◽

Cited By ~ 1

Author(s):

Bernard Randall Baker ◽

Rich B. Meyer

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

Irreversible enzyme inhibitors. CXII. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine substituted with a terminal sulfonyl fluoride. 2

Journal of Medicinal Chemistry ◽

10.1021/jm00307a007 ◽

1968 ◽

Vol 11 (1) ◽

pp. 38-41 ◽

Cited By ~ 5

Author(s):

Bernard Randall Baker ◽

Gerhardus J. Lourens

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

Irreversible enzyme inhibitors. CXLVII. Candidate active-site- directed irreversible inhibitors of xanthine oxidase derived from 9-(p-acylaminoalkoxyphenyl)guanines bearing a terminal sulfonyl fluoride

Journal of Medicinal Chemistry ◽

10.1021/jm00302a004 ◽

1969 ◽

Vol 12 (2) ◽

pp. 214-216 ◽

Cited By ~ 14

Author(s):

Bernard Randall Baker ◽

William F. Wood

Keyword(s):

Xanthine Oxidase ◽

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

Irreversible enzyme inhibitors. CLV. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 1-[4-.omega.-aminoalkoxy)-3-chlorophenyl]-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazines bearing a terminal sulfonyl fluoride

Journal of Medicinal Chemistry ◽

10.1021/jm00304a025 ◽

1969 ◽

Vol 12 (4) ◽

pp. 672-676 ◽

Cited By ~ 2

Author(s):

Bernard Randall Baker ◽

Eunice E. Janson

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

Irreversible enzyme inhibitors. CXIX. Active-site-directed irreversible inhibitors of dihydrofolic reductase with tissue specificity derived from 2,4,6-triaminopyrimidine with a terminal sulfonyl fluoride at the 5 position

Journal of Medicinal Chemistry ◽

10.1021/jm00309a018 ◽

1968 ◽

Vol 11 (3) ◽

pp. 489-494 ◽

Cited By ~ 6

Author(s):

Bernard Randall Baker ◽

Rich B. Meyer

Keyword(s):

Active Site ◽

Tissue Specificity ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

Irreversible enzyme inhibitors. CLXXII. Proteolytic enzymes. XVI. Covalent bonding of the sulfonyl fluoride group to serine outside the active-site of .alpha.-chymotrypsin by exo-type active-site directed irreversible inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm00297a030 ◽

1970 ◽

Vol 13 (3) ◽

pp. 467-470 ◽

Cited By ~ 10

Author(s):

Robert Cardinaud ◽

Bernard Randall Baker

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Proteolytic Enzymes ◽

Covalent Bonding ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

Irreversible enzyme inhibitors. CXLIV. Proteolytic enzymes. 7. Additional active-site-directed irreversible inhibitors of trypsin derived from m- and p-(phenoxyalkoxy)benzamidines with a terminal sulfonyl fluoride

Journal of Medicinal Chemistry ◽

10.1021/jm00301a029 ◽

1969 ◽

Vol 12 (1) ◽

pp. 112-117 ◽

Cited By ~ 9

Author(s):

Bernard Randall Baker ◽

Edward H. Erickson

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Proteolytic Enzymes ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

Irreversible enzyme inhibitors. CXXV. Active site-directed irreversible inhibitors of xanthine oxidase derived from arylpurines and pyrazolo[3,4-d]pyrimidines bearing a terminal sulfonyl fluoride

Journal of Medicinal Chemistry ◽

10.1021/jm00310a005 ◽

1968 ◽

Vol 11 (4) ◽

pp. 656-661 ◽

Cited By ~ 11

Author(s):

B. R. Baker ◽

Janos A. Kozma

Keyword(s):

Xanthine Oxidase ◽

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

Irreversible enzyme inhibitors. CXV. Proteolytic enzymes. 5. Active-site-directed irreversible inhibitors of trypsin derived from p-(phenoxyalkoxy)benzamidines with a terminal sulfonyl fluoride

Journal of Medicinal Chemistry ◽

10.1021/jm00308a011 ◽

1968 ◽

Vol 11 (2) ◽

pp. 245-249 ◽

Cited By ~ 9

Author(s):

Bernard Randall Baker ◽

Edward H. Erickson

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Proteolytic Enzymes ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

Irreversible enzyme inhibitors. CXIV. Proteolytic enzymes. 4. Additional active-site-directed irreversible inhibitors of .alpha.-chymotrypsin derived from phenoxyacetamides bearing a terminal sulfonyl fluoride

Journal of Medicinal Chemistry ◽

10.1021/jm00308a010 ◽

1968 ◽

Vol 11 (2) ◽

pp. 241-245 ◽

Cited By ~ 5

Author(s):

Bernard Randall Baker ◽

Jeffrey A. Hurlbut

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Proteolytic Enzymes ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

Irreversible enzyme inhibitors. CXXXVII. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 6-(p-aminomethylphenoxymethyl)-2,4-diamino-5-(3,4-dichlorophenyl)pyrimidine bearing a terminal sulfonyl fluoride

Journal of Medicinal Chemistry ◽

10.1021/jm00301a022 ◽

1969 ◽

Vol 12 (1) ◽

pp. 86-88 ◽

Cited By ~ 1

Author(s):

Bernard Randall Baker ◽

Nicolaas M. J. Vermeulen

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride