Bicyclic lactones derived from kainic acid as novel selective antagonists of neuroexcitatory amino acids

1983 ◽  
Vol 26 (1) ◽  
pp. 39-42 ◽  
Author(s):  
Ora Goldberg ◽  
Alberto Luini ◽  
Vivian I. Teichberg
Keyword(s):  
Amino Acids ◽  
Kainic Acid ◽  
Selective Antagonists ◽  
Bicyclic Lactones

ChemInform Abstract: BICYCLIC LACTONES DERIVED FROM KAINIC ACID AS NOVEL SELECTIVE ANTAGONISTS OF NEUROEXCITATORY AMINO ACIDS

1983 ◽  
Vol 14 (26) ◽  
Author(s):  
O. GOLDBERG ◽  
A. LUINI ◽  
V. I. TEICHBERG
Keyword(s):  
Amino Acids ◽  
Kainic Acid ◽  
Selective Antagonists ◽  
Bicyclic Lactones

Neuroexcitatory amino acids: phosphonic analogue of kainic acid

Amino Acids ◽  
1992 ◽  
Vol 2 (1-2) ◽  
pp. 191-193 ◽  
Author(s):  
M. Tabcheh ◽  
L. Pappalardo ◽  
M. -L. Roumestant ◽  
Ph. Viallefont
Keyword(s):  
Amino Acids ◽  
Kainic Acid ◽  
Phosphonic Analogue

ChemInform Abstract: SYNTHESIS OF NOVEL NEUROEXCITATORY AMINO ACIDS DERIVED FROM KAINIC ACID

1980 ◽  
Vol 11 (37) ◽  
Author(s):  
O. GOLDBERG ◽  
A. LUINI ◽  
V. I. TEICHBERG
Keyword(s):  
Amino Acids ◽  
Kainic Acid

Breathing of awake goats during prolonged dysfunction of caudal M ventrolateral medullary neurons

1998 ◽  
Vol 84 (1) ◽  
pp. 129-140 ◽  
Author(s):  
H. V. Forster ◽  
L. G. Pan ◽  
T. F. Lowry ◽  
T. Feroah ◽  
W. M. Gershan ◽  
...  
Keyword(s):  
Amino Acid ◽  
Aspartic Acid ◽  
Kainic Acid ◽  
Excitatory Amino Acid ◽  
Neuronal Dysfunction ◽  
Excitatory Amino Acid Receptor ◽  
Acid Receptor ◽  
Awake State ◽  
Selective Antagonists ◽  
Medullary Neurons

Forster, H. V., L. G. Pan, T. F. Lowry, T. Feroah, W. M. Gershan, A. A. Whaley, M. M. Forster, and B. Sprtel. Breathing of awake goats during prolonged dysfunction of caudal M ventrolateral medullary neurons. J. Appl. Physiol.84(1): 129–140, 1998.—Cooling the caudal M ventrolateral medullary (VLM) surface for 30 s results in a sustained apnea in anesthetized goats but only a 30% decrease in breathing in awake goats. The purpose of the present study was to determine, in the awake state, the effect of prolonged (minutes, hours) caudal M neuronal dysfunction on eupneic breathing and CO2 sensitivity. Dysfunction was created by ejecting excitatory amino acid receptor antagonists or a neurotoxin on the VLM surface through guide tubes chronically implanted bilaterally on a 10- to 12-mm2portion of the caudal M VLM surface of 12 goats. Unilateral and bilateral ejections (1 μl) of selective antagonists for N-methyl-d-aspartic acid or non- N-methyl-d-aspartic acid receptors had no significant effect on eupneic breathing or CO2 sensitivity. Unilateral ejection of a nonselective excitatory amino acid receptor antagonist generally had no effect on eupneic breathing or CO2 sensitivity. However, bilateral ejection of this antagonist resulted in a significant 2-Torr hypoventilation during eupnea and a significant reduction in CO2 sensitivity to 60 ± 9% of control. Unilateral ejection of the neurotoxin kainic acid initially stimulated breathing; however, breathing then returned to near control with no incidence of apnea. After the kainic acid ejection, CO2 sensitivity was reduced significantly to 60 ± 7% of control. We conclude that in the awake state a prolonged dysfunction of caudal M VLM neurons results in compensation by other mechanisms (e.g., carotid chemoreceptors, wakefulness) to maintain near-normal eupneic breathing, but compensation is more limited for maintaining CO2 sensitivity.

Comparative toxicity of kainic acid and other acidic amino acids toward rat hippocampal neurons

Neuroscience ◽  
1981 ◽  
Vol 6 (12) ◽  
pp. 2505-2517 ◽  
Author(s):  
J.V. Nadler ◽  
D.A. Evenson ◽  
G.J. Cuthbertson
Keyword(s):  
Amino Acids ◽  
Kainic Acid ◽  
Hippocampal Neurons ◽  
Acidic Amino Acids ◽  
Comparative Toxicity

Lactones derived from kainic acid: Novel selective antagonists of amino acid-induced Na+ fluxes in rat striatum slices

1981 ◽  
Vol 23 (2) ◽  
pp. 187-191 ◽  
Author(s):  
Ora Goldberg ◽  
Alberto Luini ◽  
Vivian I. Teichberg
Keyword(s):  
Amino Acid ◽  
Kainic Acid ◽  
Rat Striatum ◽  
Selective Antagonists

Glucocorticoids Exacerbate Kainic Acid?Induced Extracellular Accumulation of Excitatory Amino Acids in the Rat Hippocampus

1992 ◽  
Vol 58 (5) ◽  
pp. 1730-1735 ◽  
Author(s):  
Becky A. Stein-Behrens ◽  
Elicia M. Elliott ◽  
Chris A. Miller ◽  
James W. Schilling ◽  
Robert Newcombe ◽  
...  
Keyword(s):  
Amino Acids ◽  
Kainic Acid ◽  
Excitatory Amino Acids ◽  
Rat Hippocampus

Kainic acid stimulation of cerebellar cyclic GMP levels: Potentiation by glutamate and related amino acids

1981 ◽  
Vol 23 (1) ◽  
pp. 67-70 ◽  
Author(s):  
G.A. Foster ◽  
P.J. Roberts
Keyword(s):  
Amino Acids ◽  
Kainic Acid ◽  
Cyclic Gmp ◽  
Stimulation Of
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